Abstract
The efficient time schedule and prioritization of vaccine supplies are important in mitigating impact of an influenza pandemic. In practice, there are restrictions associated with limited vaccination coverage and the maximum daily vaccine administration. We extend previous work on optimal control for influenza to reflect these realistic restrictions using mixed constraints on state and control variables. An optimal control problem is formulated with the aim of minimizing the number of infected individuals while considering intervention costs. Time-dependent vaccination is computed and analysed using a model incorporating heterogeneity in population structure under different settings of transmissibility levels, vaccine coverages, and time delays.
Original language | English |
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Pages (from-to) | 2313-2329 |
Number of pages | 17 |
Journal | Computers and Mathematics with Applications |
Volume | 71 |
Issue number | 11 |
DOIs | |
Publication status | Published - 2016 Jun 1 |
Bibliographical note
Publisher Copyright:© 2016 Elsevier Ltd.
All Science Journal Classification (ASJC) codes
- Modelling and Simulation
- Computational Theory and Mathematics
- Computational Mathematics