The efficient time schedule and prioritization of vaccine supplies are important in mitigating impact of an influenza pandemic. In practice, there are restrictions associated with limited vaccination coverage and the maximum daily vaccine administration. We extend previous work on optimal control for influenza to reflect these realistic restrictions using mixed constraints on state and control variables. An optimal control problem is formulated with the aim of minimizing the number of infected individuals while considering intervention costs. Time-dependent vaccination is computed and analysed using a model incorporating heterogeneity in population structure under different settings of transmissibility levels, vaccine coverages, and time delays.
Bibliographical noteFunding Information:
The work of Hee-Dae Kwon was supported by the NRF Grant funded by the Korean government ( NRF-2014R1A1A2056498 ). The work of Jeehyun Lee was supported by NRF grant 2015 R1A5A1009350 .
All Science Journal Classification (ASJC) codes
- Modelling and Simulation
- Computational Theory and Mathematics
- Computational Mathematics