Construction of benzo-fused indolizines, pyrrolo[1,2-a]quinolines via alkyne-carbonyl metathesis

Maloy Nayak, Ikyon Kim

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

The strategic use of a sequential Sonogashira coupling/intramolecular alkyne-carbonyl metathesis process for the synthesis of a pyridine ring from 1-(2-haloaryl)-1H-pyrrole-2-carbaldehydes allowed ready access to diverse novel benzo-fused indolizines, pyrrolo[1,2-a]quinolines, in good to excellent yields. As a hybrid structure of indolizine and quinoline, the resulting scaffold has an acyl substituent at the C5 position, which is difficult to make by any other known approaches.

Original languageEnglish
Pages (from-to)9697-9708
Number of pages12
JournalOrganic and Biomolecular Chemistry
Volume13
Issue number37
DOIs
Publication statusPublished - 2015 Aug 7

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Indolizines
Quinolines
Alkynes
metathesis
quinoline
alkynes
Scaffolds
hybrid structures
pyrroles
pyridines
rings
synthesis
pyrrole-2-carboxaldehyde
pyridine
indolizine

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

Cite this

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Construction of benzo-fused indolizines, pyrrolo[1,2-a]quinolines via alkyne-carbonyl metathesis. / Nayak, Maloy; Kim, Ikyon.

In: Organic and Biomolecular Chemistry, Vol. 13, No. 37, 07.08.2015, p. 9697-9708.

Research output: Contribution to journalArticle

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