A case of contact dermatitis to isoconazole nitrate (Travogen) which developed in a 41-year-old male who used it for the treatment of tinea cruris is described. The patient had been treated with multiple creams including Travogen (isoconazole nitrate), Mycospor (bifonazole) and Lidex (0.25% fluocinonide) before the sudden appearance of the eczematous rash on his groin and thigh. The patch test result showed that he was sensitive to multiple imidazole derivatives (isoconazole, bifonazole, ciclopirox) as well as isoconazole nitrate (1% in petrolatum), which suggests allergic contact dermatitis due to isoconazole nitrate. We recommended haloprogin cream for the treatment of tinea cruris. After one year follow up period, the patient was free of skin lesion.
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