Continuous-Flow Kinetic Resolution of (±)- cis -1-Amino-2-indanol by Lipase-Catalyzed N-Acetylation

Yoon Jung Kim, Yong Sung Choi, Sai Yang, Woo Ram Yang, Jin Hyun Jeong

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Selective N-acetylation of (1S,2R)-1-amino-2-indanol by immobilized lipase B from Candida antarctica showed high enantiomeric excess when ethyl acetate was used as the acyl donor in a THF solution. Combining this process with continuous-flow system, we could obtain enantiomerically pure N-acetyl-aminoindanol at a flow rate of 0.1 mL/min (residence time of 64 min). It has been demonstrated to be more efficient compared to the flask mode.

Original languageEnglish
Article numberst-2015-u0295-l
Pages (from-to)1981-1984
Number of pages4
JournalSynlett
Volume26
Issue number14
DOIs
Publication statusPublished - 2015 Sep 1

All Science Journal Classification (ASJC) codes

  • Organic Chemistry

Fingerprint Dive into the research topics of 'Continuous-Flow Kinetic Resolution of (±)- cis -1-Amino-2-indanol by Lipase-Catalyzed N-Acetylation'. Together they form a unique fingerprint.

  • Cite this