Continuous monitoring of deep-tissue haemodynamics with stretchable ultrasonic phased arrays

Chonghe Wang; Baiyan Qi; Muyang Lin; Zhuorui Zhang; Mitsutoshi Makihata; Boyu Liu; Sai Zhou; Yi hsi Huang; Hongjie Hu; Yue Gu; Yimu Chen; Yusheng Lei; Taeyoon Lee; Shu Chien; Kyung In Jang; Erik B. Kistler; Sheng Xu

doi:10.1038/s41551-021-00763-4

Continuous monitoring of deep-tissue haemodynamics with stretchable ultrasonic phased arrays

Chonghe Wang, Baiyan Qi, Muyang Lin, Zhuorui Zhang, Mitsutoshi Makihata, Boyu Liu, Sai Zhou, Yi hsi Huang, Hongjie Hu, Yue Gu, Yimu Chen, Yusheng Lei, Taeyoon Lee, Shu Chien, Kyung In Jang, Erik B. Kistler, Sheng Xu

Department of Electrical and Electronic Engineering

Research output: Contribution to journal › Article › peer-review

46 Citations (Scopus)

Abstract

Stretchable wearable devices for the continuous monitoring of physiological signals from deep tissues are constrained by the depth of signal penetration and by difficulties in resolving signals from specific tissues. Here, we report the development and testing of a prototype skin-conformal ultrasonic phased array for the monitoring of haemodynamic signals from tissues up to 14 cm beneath the skin. The device allows for active focusing and steering of ultrasound beams over a range of incident angles so as to target regions of interest. In healthy volunteers, we show that the phased array can be used to monitor Doppler spectra from cardiac tissues, record central blood flow waveforms and estimate cerebral blood supply in real time. Stretchable and conformal skin-worn ultrasonic phased arrays may open up opportunities for wearable diagnostics.

Original language	English
Pages (from-to)	749-758
Number of pages	10
Journal	Nature biomedical engineering
Volume	5
Issue number	7
DOIs	https://doi.org/10.1038/s41551-021-00763-4
Publication status	Published - 2021 Jul

Bibliographical note

Funding Information:
We thank Z. Wu and L. Chen for guidance on the ultrasonic imaging algorithm and data processing; S. Xiang for feedback on manuscript preparation; and Y. Hu and Z. Liu for advice on the cardiac tissue Doppler experiments. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health (NIH). All biological experiments were conducted in accordance with the ethical guidelines of the NIH and with the approval of the IRB of the University of California, San Diego (IRB number 170812). We acknowledge support from the NIH (grant 1R21EB027303-01A1) and the Center for Wearable Sensors at the University of California, San Diego.

Publisher Copyright:
© 2021, The Author(s), under exclusive licence to Springer Nature Limited.

All Science Journal Classification (ASJC) codes

Biotechnology
Bioengineering
Medicine (miscellaneous)
Biomedical Engineering
Computer Science Applications

Access to Document

10.1038/s41551-021-00763-4

Cite this

@article{a7e3cc463bac4ed2a9e51a44937a57a5,

title = "Continuous monitoring of deep-tissue haemodynamics with stretchable ultrasonic phased arrays",

abstract = "Stretchable wearable devices for the continuous monitoring of physiological signals from deep tissues are constrained by the depth of signal penetration and by difficulties in resolving signals from specific tissues. Here, we report the development and testing of a prototype skin-conformal ultrasonic phased array for the monitoring of haemodynamic signals from tissues up to 14 cm beneath the skin. The device allows for active focusing and steering of ultrasound beams over a range of incident angles so as to target regions of interest. In healthy volunteers, we show that the phased array can be used to monitor Doppler spectra from cardiac tissues, record central blood flow waveforms and estimate cerebral blood supply in real time. Stretchable and conformal skin-worn ultrasonic phased arrays may open up opportunities for wearable diagnostics.",

author = "Chonghe Wang and Baiyan Qi and Muyang Lin and Zhuorui Zhang and Mitsutoshi Makihata and Boyu Liu and Sai Zhou and Huang, {Yi hsi} and Hongjie Hu and Yue Gu and Yimu Chen and Yusheng Lei and Taeyoon Lee and Shu Chien and Jang, {Kyung In} and Kistler, {Erik B.} and Sheng Xu",

note = "Funding Information: We thank Z. Wu and L. Chen for guidance on the ultrasonic imaging algorithm and data processing; S. Xiang for feedback on manuscript preparation; and Y. Hu and Z. Liu for advice on the cardiac tissue Doppler experiments. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health (NIH). All biological experiments were conducted in accordance with the ethical guidelines of the NIH and with the approval of the IRB of the University of California, San Diego (IRB number 170812). We acknowledge support from the NIH (grant 1R21EB027303-01A1) and the Center for Wearable Sensors at the University of California, San Diego. Publisher Copyright: {\textcopyright} 2021, The Author(s), under exclusive licence to Springer Nature Limited.",

year = "2021",

month = jul,

doi = "10.1038/s41551-021-00763-4",

language = "English",

volume = "5",

pages = "749--758",

journal = "Nature Biomedical Engineering",

issn = "2157-846X",

publisher = "Nature Publishing Group",

number = "7",

}

TY - JOUR

T1 - Continuous monitoring of deep-tissue haemodynamics with stretchable ultrasonic phased arrays

AU - Wang, Chonghe

AU - Qi, Baiyan

AU - Lin, Muyang

AU - Zhang, Zhuorui

AU - Makihata, Mitsutoshi

AU - Liu, Boyu

AU - Zhou, Sai

AU - Huang, Yi hsi

AU - Hu, Hongjie

AU - Gu, Yue

AU - Chen, Yimu

AU - Lei, Yusheng

AU - Lee, Taeyoon

AU - Chien, Shu

AU - Jang, Kyung In

AU - Kistler, Erik B.

AU - Xu, Sheng

N1 - Funding Information: We thank Z. Wu and L. Chen for guidance on the ultrasonic imaging algorithm and data processing; S. Xiang for feedback on manuscript preparation; and Y. Hu and Z. Liu for advice on the cardiac tissue Doppler experiments. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health (NIH). All biological experiments were conducted in accordance with the ethical guidelines of the NIH and with the approval of the IRB of the University of California, San Diego (IRB number 170812). We acknowledge support from the NIH (grant 1R21EB027303-01A1) and the Center for Wearable Sensors at the University of California, San Diego. Publisher Copyright: © 2021, The Author(s), under exclusive licence to Springer Nature Limited.

PY - 2021/7

Y1 - 2021/7

N2 - Stretchable wearable devices for the continuous monitoring of physiological signals from deep tissues are constrained by the depth of signal penetration and by difficulties in resolving signals from specific tissues. Here, we report the development and testing of a prototype skin-conformal ultrasonic phased array for the monitoring of haemodynamic signals from tissues up to 14 cm beneath the skin. The device allows for active focusing and steering of ultrasound beams over a range of incident angles so as to target regions of interest. In healthy volunteers, we show that the phased array can be used to monitor Doppler spectra from cardiac tissues, record central blood flow waveforms and estimate cerebral blood supply in real time. Stretchable and conformal skin-worn ultrasonic phased arrays may open up opportunities for wearable diagnostics.

AB - Stretchable wearable devices for the continuous monitoring of physiological signals from deep tissues are constrained by the depth of signal penetration and by difficulties in resolving signals from specific tissues. Here, we report the development and testing of a prototype skin-conformal ultrasonic phased array for the monitoring of haemodynamic signals from tissues up to 14 cm beneath the skin. The device allows for active focusing and steering of ultrasound beams over a range of incident angles so as to target regions of interest. In healthy volunteers, we show that the phased array can be used to monitor Doppler spectra from cardiac tissues, record central blood flow waveforms and estimate cerebral blood supply in real time. Stretchable and conformal skin-worn ultrasonic phased arrays may open up opportunities for wearable diagnostics.

UR - http://www.scopus.com/inward/record.url?scp=85110716459&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85110716459&partnerID=8YFLogxK

U2 - 10.1038/s41551-021-00763-4

DO - 10.1038/s41551-021-00763-4

M3 - Article

C2 - 34272524

AN - SCOPUS:85110716459

SN - 2157-846X

VL - 5

SP - 749

EP - 758

JO - Nature Biomedical Engineering

JF - Nature Biomedical Engineering

IS - 7

ER -

Continuous monitoring of deep-tissue haemodynamics with stretchable ultrasonic phased arrays

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this