Continuous Positive Airway Pressure Therapy Restores Cardiac Mechanical Function in Patients With Severe Obstructive Sleep Apnea: A Randomized, Sham-Controlled Study

Darae Kim, Chi Young Shim, Yang Je Cho, Sungha Park, Chan Joo Lee, Joo Hee Park, Hyoung Joo Cho, Jong Won Ha, Geu Ru Hong

Research output: Contribution to journalArticle

Abstract

Background: Continuous positive airway pressure (CPAP) therapy might decrease left ventricular (LV) and right ventricular (RV) loads and improve cardiac mechanical function in patients with obstructive sleep apnea (OSA). However, the benefits of CPAP therapy for cardiac mechanical function in patients with OSA have not previously been proved in a randomized, sham-controlled clinical trial. This study therefore investigated the effects of CPAP therapy on LV and RV mechanical function in patients with severe OSA and compared them with the effects of a sham intervention. Methods: In this randomized sham-controlled trial, we analyzed LV and RV function by conventional and speckle-tracking echocardiography before and after 3 months of treatment in 52 patients with severe OSA. Patients were randomly assigned (1:1) to receive either CPAP or sham treatment for 3 months. The main investigator and patients were masked to the trial randomization. Results: After 3 months, CPAP treatment significantly improved LV global longitudinal strain (GLS) compared with the sham treatment (–20.0% ± 2.1% vs –18.0% ± 2.5%; P = .004), although there were no differences in LV dimension or ejection fraction. CPAP treatment reduced RV size and improved the fractional area change (51.3% ± 7.9% vs 46.9% ± 6.7%; P = .038) compared with the sham treatment. CPAP treatment did not ameliorate the RV GLS compared with the sham treatment. Conclusions: In patients with severe OSA, CPAP treatment for 3 months improved LV and RV function compared with sham treatment. LV mechanical function assessed by speckle-tracking echocardiography and RV fractional area change assessed by two-dimensional echocardiography were significantly improved by CPAP treatment.

Original languageEnglish
Pages (from-to)826-835
Number of pages10
JournalJournal of the American Society of Echocardiography
Volume32
Issue number7
DOIs
Publication statusPublished - 2019 Jul

Fingerprint

Continuous Positive Airway Pressure
Obstructive Sleep Apnea
Right Ventricular Function
Placebos
Echocardiography
Therapeutics
Randomized Controlled Trials
Random Allocation
Left Ventricular Function
Research Personnel

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

Cite this

@article{8d258a042e9f4d67a77b09150dc28e3d,
title = "Continuous Positive Airway Pressure Therapy Restores Cardiac Mechanical Function in Patients With Severe Obstructive Sleep Apnea: A Randomized, Sham-Controlled Study",
abstract = "Background: Continuous positive airway pressure (CPAP) therapy might decrease left ventricular (LV) and right ventricular (RV) loads and improve cardiac mechanical function in patients with obstructive sleep apnea (OSA). However, the benefits of CPAP therapy for cardiac mechanical function in patients with OSA have not previously been proved in a randomized, sham-controlled clinical trial. This study therefore investigated the effects of CPAP therapy on LV and RV mechanical function in patients with severe OSA and compared them with the effects of a sham intervention. Methods: In this randomized sham-controlled trial, we analyzed LV and RV function by conventional and speckle-tracking echocardiography before and after 3 months of treatment in 52 patients with severe OSA. Patients were randomly assigned (1:1) to receive either CPAP or sham treatment for 3 months. The main investigator and patients were masked to the trial randomization. Results: After 3 months, CPAP treatment significantly improved LV global longitudinal strain (GLS) compared with the sham treatment (–20.0{\%} ± 2.1{\%} vs –18.0{\%} ± 2.5{\%}; P = .004), although there were no differences in LV dimension or ejection fraction. CPAP treatment reduced RV size and improved the fractional area change (51.3{\%} ± 7.9{\%} vs 46.9{\%} ± 6.7{\%}; P = .038) compared with the sham treatment. CPAP treatment did not ameliorate the RV GLS compared with the sham treatment. Conclusions: In patients with severe OSA, CPAP treatment for 3 months improved LV and RV function compared with sham treatment. LV mechanical function assessed by speckle-tracking echocardiography and RV fractional area change assessed by two-dimensional echocardiography were significantly improved by CPAP treatment.",
author = "Darae Kim and Shim, {Chi Young} and Cho, {Yang Je} and Sungha Park and Lee, {Chan Joo} and Park, {Joo Hee} and Cho, {Hyoung Joo} and Ha, {Jong Won} and Hong, {Geu Ru}",
year = "2019",
month = "7",
doi = "10.1016/j.echo.2019.03.020",
language = "English",
volume = "32",
pages = "826--835",
journal = "Journal of the American Society of Echocardiography",
issn = "0894-7317",
publisher = "Mosby Inc.",
number = "7",

}

Continuous Positive Airway Pressure Therapy Restores Cardiac Mechanical Function in Patients With Severe Obstructive Sleep Apnea : A Randomized, Sham-Controlled Study. / Kim, Darae; Shim, Chi Young; Cho, Yang Je; Park, Sungha; Lee, Chan Joo; Park, Joo Hee; Cho, Hyoung Joo; Ha, Jong Won; Hong, Geu Ru.

In: Journal of the American Society of Echocardiography, Vol. 32, No. 7, 07.2019, p. 826-835.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Continuous Positive Airway Pressure Therapy Restores Cardiac Mechanical Function in Patients With Severe Obstructive Sleep Apnea

T2 - A Randomized, Sham-Controlled Study

AU - Kim, Darae

AU - Shim, Chi Young

AU - Cho, Yang Je

AU - Park, Sungha

AU - Lee, Chan Joo

AU - Park, Joo Hee

AU - Cho, Hyoung Joo

AU - Ha, Jong Won

AU - Hong, Geu Ru

PY - 2019/7

Y1 - 2019/7

N2 - Background: Continuous positive airway pressure (CPAP) therapy might decrease left ventricular (LV) and right ventricular (RV) loads and improve cardiac mechanical function in patients with obstructive sleep apnea (OSA). However, the benefits of CPAP therapy for cardiac mechanical function in patients with OSA have not previously been proved in a randomized, sham-controlled clinical trial. This study therefore investigated the effects of CPAP therapy on LV and RV mechanical function in patients with severe OSA and compared them with the effects of a sham intervention. Methods: In this randomized sham-controlled trial, we analyzed LV and RV function by conventional and speckle-tracking echocardiography before and after 3 months of treatment in 52 patients with severe OSA. Patients were randomly assigned (1:1) to receive either CPAP or sham treatment for 3 months. The main investigator and patients were masked to the trial randomization. Results: After 3 months, CPAP treatment significantly improved LV global longitudinal strain (GLS) compared with the sham treatment (–20.0% ± 2.1% vs –18.0% ± 2.5%; P = .004), although there were no differences in LV dimension or ejection fraction. CPAP treatment reduced RV size and improved the fractional area change (51.3% ± 7.9% vs 46.9% ± 6.7%; P = .038) compared with the sham treatment. CPAP treatment did not ameliorate the RV GLS compared with the sham treatment. Conclusions: In patients with severe OSA, CPAP treatment for 3 months improved LV and RV function compared with sham treatment. LV mechanical function assessed by speckle-tracking echocardiography and RV fractional area change assessed by two-dimensional echocardiography were significantly improved by CPAP treatment.

AB - Background: Continuous positive airway pressure (CPAP) therapy might decrease left ventricular (LV) and right ventricular (RV) loads and improve cardiac mechanical function in patients with obstructive sleep apnea (OSA). However, the benefits of CPAP therapy for cardiac mechanical function in patients with OSA have not previously been proved in a randomized, sham-controlled clinical trial. This study therefore investigated the effects of CPAP therapy on LV and RV mechanical function in patients with severe OSA and compared them with the effects of a sham intervention. Methods: In this randomized sham-controlled trial, we analyzed LV and RV function by conventional and speckle-tracking echocardiography before and after 3 months of treatment in 52 patients with severe OSA. Patients were randomly assigned (1:1) to receive either CPAP or sham treatment for 3 months. The main investigator and patients were masked to the trial randomization. Results: After 3 months, CPAP treatment significantly improved LV global longitudinal strain (GLS) compared with the sham treatment (–20.0% ± 2.1% vs –18.0% ± 2.5%; P = .004), although there were no differences in LV dimension or ejection fraction. CPAP treatment reduced RV size and improved the fractional area change (51.3% ± 7.9% vs 46.9% ± 6.7%; P = .038) compared with the sham treatment. CPAP treatment did not ameliorate the RV GLS compared with the sham treatment. Conclusions: In patients with severe OSA, CPAP treatment for 3 months improved LV and RV function compared with sham treatment. LV mechanical function assessed by speckle-tracking echocardiography and RV fractional area change assessed by two-dimensional echocardiography were significantly improved by CPAP treatment.

UR - http://www.scopus.com/inward/record.url?scp=85067833861&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85067833861&partnerID=8YFLogxK

U2 - 10.1016/j.echo.2019.03.020

DO - 10.1016/j.echo.2019.03.020

M3 - Article

C2 - 31272592

AN - SCOPUS:85067833861

VL - 32

SP - 826

EP - 835

JO - Journal of the American Society of Echocardiography

JF - Journal of the American Society of Echocardiography

SN - 0894-7317

IS - 7

ER -