Control of autophagy with small molecules

Yoon Sun Cho, Ho Jeong Kwon

Research output: Contribution to journalReview article

8 Citations (Scopus)

Abstract

Autophagy is the mass degradation system that removes long-lived proteins and malfunctioning organelles within the cell. Dysfunctional autophagic processes can cause various diseases such as cancer and neurodegenerative disorders, but the underlying mechanisms responsible for such events remain undefined. Small molecules that control autophagy could be powerful tools to reveal autophagy mechanisms, and to develop treatments for autophagy-related diseases including Alzheimer's disease, Parkinson's disease and various cancer types. This review discusses the small molecules that have been identified to control autophagy and how they can be used to understand signaling pathways important for autophagy in the context of chemical genomics.

Original languageEnglish
Pages (from-to)1881-1889
Number of pages9
JournalArchives of pharmacal research
Volume33
Issue number12
DOIs
Publication statusPublished - 2010 Dec 1

Fingerprint

Autophagy
Molecules
Genomics
Degradation
Neurodegenerative Diseases
Organelles
Parkinson Disease
Neoplasms
Alzheimer Disease
Proteins

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Drug Discovery
  • Organic Chemistry

Cite this

Cho, Yoon Sun ; Kwon, Ho Jeong. / Control of autophagy with small molecules. In: Archives of pharmacal research. 2010 ; Vol. 33, No. 12. pp. 1881-1889.
@article{62350b7f134d44dba93c72f5cc5e55d4,
title = "Control of autophagy with small molecules",
abstract = "Autophagy is the mass degradation system that removes long-lived proteins and malfunctioning organelles within the cell. Dysfunctional autophagic processes can cause various diseases such as cancer and neurodegenerative disorders, but the underlying mechanisms responsible for such events remain undefined. Small molecules that control autophagy could be powerful tools to reveal autophagy mechanisms, and to develop treatments for autophagy-related diseases including Alzheimer's disease, Parkinson's disease and various cancer types. This review discusses the small molecules that have been identified to control autophagy and how they can be used to understand signaling pathways important for autophagy in the context of chemical genomics.",
author = "Cho, {Yoon Sun} and Kwon, {Ho Jeong}",
year = "2010",
month = "12",
day = "1",
doi = "10.1007/s12272-010-1201-6",
language = "English",
volume = "33",
pages = "1881--1889",
journal = "Archives of Pharmacal Research",
issn = "0253-6269",
publisher = "Pharmaceutical Society of Korea",
number = "12",

}

Control of autophagy with small molecules. / Cho, Yoon Sun; Kwon, Ho Jeong.

In: Archives of pharmacal research, Vol. 33, No. 12, 01.12.2010, p. 1881-1889.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Control of autophagy with small molecules

AU - Cho, Yoon Sun

AU - Kwon, Ho Jeong

PY - 2010/12/1

Y1 - 2010/12/1

N2 - Autophagy is the mass degradation system that removes long-lived proteins and malfunctioning organelles within the cell. Dysfunctional autophagic processes can cause various diseases such as cancer and neurodegenerative disorders, but the underlying mechanisms responsible for such events remain undefined. Small molecules that control autophagy could be powerful tools to reveal autophagy mechanisms, and to develop treatments for autophagy-related diseases including Alzheimer's disease, Parkinson's disease and various cancer types. This review discusses the small molecules that have been identified to control autophagy and how they can be used to understand signaling pathways important for autophagy in the context of chemical genomics.

AB - Autophagy is the mass degradation system that removes long-lived proteins and malfunctioning organelles within the cell. Dysfunctional autophagic processes can cause various diseases such as cancer and neurodegenerative disorders, but the underlying mechanisms responsible for such events remain undefined. Small molecules that control autophagy could be powerful tools to reveal autophagy mechanisms, and to develop treatments for autophagy-related diseases including Alzheimer's disease, Parkinson's disease and various cancer types. This review discusses the small molecules that have been identified to control autophagy and how they can be used to understand signaling pathways important for autophagy in the context of chemical genomics.

UR - http://www.scopus.com/inward/record.url?scp=78751545090&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=78751545090&partnerID=8YFLogxK

U2 - 10.1007/s12272-010-1201-6

DO - 10.1007/s12272-010-1201-6

M3 - Review article

C2 - 21191751

AN - SCOPUS:78751545090

VL - 33

SP - 1881

EP - 1889

JO - Archives of Pharmacal Research

JF - Archives of Pharmacal Research

SN - 0253-6269

IS - 12

ER -