When there is no pulmonary vein reconnection after catheter ablation for atrial fibrillation, patients can experience recurrence of atrial fibrillation without clear evidence of non- pulmonary vein foci. We describe a patient with significant pulmonary vein stenosis and recurrent atrial fibrillation after four ablation procedures. After successful pulmonary vein stenting, the symptoms were resolved, and sinus rhythm was maintained for 2 years without treatment with antiarrhythmic medication. We believe pulmonary vein stenting potentially controlled atrial fibrillation by providing pulmonary vein pressure relief or by compressing the epicardial triggers occurring at the pulmonary vein ostium.
Bibliographical noteFunding Information:
We thank the Projects teams at the Ontario Institute for Cancer Research, Canada. We also thank the patients for participating in this study. This work was funded in part by the National Cancer Institute (1R21CA152613, P30CA023100), the CIRM Highly Active Anti-Leukemia Stem Cell Therapy (HALT) team grant (DR1-01430), the National Institutes of Health Grant UL1TR000100 and the Government of Canada through Genome Canada and through the Canadian Institutes of Health Research (CSC-105367). The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH. PJS was supported by the UCSD Cancer Center Training Grant in Drug Development—the Cancer Therapeutics Training Program T32CA121938. This work was also supported by the Cancer Stem Cell Consortium with funding from the Government of Canada through Genome Canada and the Ontario Genomics Institute (OGI-047), and through the Canadian Institutes of Health Research (CSC-105367). TJH and LM received Investigator Awards from the Ontario Institute for Cancer Research, through generous support from the Ontario Ministry of Research and Innovation. Copy number arrays, exome sequencing data, targeted sequencing data, and methylation array raw data will be available through dbGaP accession phs000767: http://www.ncbi.nlm.nih.gov/projects/ gap/cgi-bin/study.cgi?study_id=phs000767.v1.p1.
© 2017 The Korean Society of Cardiology.
All Science Journal Classification (ASJC) codes
- Internal Medicine
- Cardiology and Cardiovascular Medicine