Controlled delivery of a hydrophilic drug from a biodegradable microsphere system by supercritical anti-solvent precipitation technique

S. Lee, M. S. Kim, J. S. Kim, H. J. Park, J. S. Woo, B. C. Lee, Sung Joo Hwang

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

The purpose of this study was to prepare microspheres loaded with hydrophilic drug, bupivacaine HCl using poly(D,L-lactic-co-glycolic acid) (PLGA) and poly(L-lactic acid) (PLLA). Microspheres were prepared with varying the PLGA/PLLA ratio with two different levels of bupivacaine HCl (5 and 10%) using a supercritical anti-solvent (SAS) technique. Microspheres ranging from 4-10 μm in geometric mean diameter could be prepared, with high loading efficiency. Powder X-ray diffraction (PXRD) revealed that bupivacaine HCl retained its crystalline state within the polymer and was present as a dispersion within the polymer phase after SAS processing. The release of bupivacaine HCl from biodegradable polymer microspheres was rapid up to 4h, thereafter bupivacaine HCl was continuously and slowly released for at least 7 days according to the PLGA/PLLA ratio and the molecular weight of PLLA.

Original languageEnglish
Pages (from-to)741-749
Number of pages9
JournalJournal of Microencapsulation
Volume23
Issue number7
DOIs
Publication statusPublished - 2006 Nov 1

Fingerprint

lactic acid
Lactic acid
Microspheres
delivery
drugs
Bupivacaine
Pharmaceutical Preparations
polymers
Polymers
Biodegradable polymers
X ray powder diffraction
molecular weight
Molecular weight
Crystalline materials
acids
Acids
polylactic acid-polyglycolic acid copolymer
X-Ray Diffraction
Powders
Processing

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Pharmaceutical Science
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Colloid and Surface Chemistry

Cite this

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abstract = "The purpose of this study was to prepare microspheres loaded with hydrophilic drug, bupivacaine HCl using poly(D,L-lactic-co-glycolic acid) (PLGA) and poly(L-lactic acid) (PLLA). Microspheres were prepared with varying the PLGA/PLLA ratio with two different levels of bupivacaine HCl (5 and 10{\%}) using a supercritical anti-solvent (SAS) technique. Microspheres ranging from 4-10 μm in geometric mean diameter could be prepared, with high loading efficiency. Powder X-ray diffraction (PXRD) revealed that bupivacaine HCl retained its crystalline state within the polymer and was present as a dispersion within the polymer phase after SAS processing. The release of bupivacaine HCl from biodegradable polymer microspheres was rapid up to 4h, thereafter bupivacaine HCl was continuously and slowly released for at least 7 days according to the PLGA/PLLA ratio and the molecular weight of PLLA.",
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Controlled delivery of a hydrophilic drug from a biodegradable microsphere system by supercritical anti-solvent precipitation technique. / Lee, S.; Kim, M. S.; Kim, J. S.; Park, H. J.; Woo, J. S.; Lee, B. C.; Hwang, Sung Joo.

In: Journal of Microencapsulation, Vol. 23, No. 7, 01.11.2006, p. 741-749.

Research output: Contribution to journalArticle

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