Controlled drug release in silicone adhesive utilizing particulate additives

Ji Eun Lee, Gyeong Hyeon Gwak, Hyeon Mo Cho, Cheol Hyun Kim, Myong Euy Lee, Jae Min Oh

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Polydimethylsiloxane (PDMS) based adhesives were prepared by cross-linking tetraethoxyorthosilicate (TEOS) while controlling stoichiometry with PDMS, acid catalyst, and water. Particulate additives, alginate and bentonite, were added during the cross-linking process. Cationic drug lidocaine was incorporated into the adhesive with or without additive, and the time-dependent drug release profile was evaluated in phosphate buffered saline and ethanol, respectively. According to kinetic fitting to power function and parabolic diffusion, both solvent and additive type influenced drug release. In particular, particulate additives were found to suppress or facilitate drug release in water or ethanol, respectively.

Original languageEnglish
Pages (from-to)1600-1603
Number of pages4
JournalKorean Journal of Chemical Engineering
Volume34
Issue number6
DOIs
Publication statusPublished - 2017 Jun 1

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Silicones
Adhesives
Polydimethylsiloxane
Ethanol
Pharmaceutical Preparations
Alginate
Bentonite
Stoichiometry
Water
Phosphates
Lidocaine
Catalysts
Kinetics
Acids
baysilon

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Chemical Engineering(all)

Cite this

Lee, Ji Eun ; Gwak, Gyeong Hyeon ; Cho, Hyeon Mo ; Kim, Cheol Hyun ; Lee, Myong Euy ; Oh, Jae Min. / Controlled drug release in silicone adhesive utilizing particulate additives. In: Korean Journal of Chemical Engineering. 2017 ; Vol. 34, No. 6. pp. 1600-1603.
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Controlled drug release in silicone adhesive utilizing particulate additives. / Lee, Ji Eun; Gwak, Gyeong Hyeon; Cho, Hyeon Mo; Kim, Cheol Hyun; Lee, Myong Euy; Oh, Jae Min.

In: Korean Journal of Chemical Engineering, Vol. 34, No. 6, 01.06.2017, p. 1600-1603.

Research output: Contribution to journalArticle

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