Controlled drug release in silicone adhesive utilizing particulate additives

Ji Eun Lee, Gyeong Hyeon Gwak, Hyeon Mo Cho, Cheol Hyun Kim, Myong Euy Lee, Jae Min Oh

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Polydimethylsiloxane (PDMS) based adhesives were prepared by cross-linking tetraethoxyorthosilicate (TEOS) while controlling stoichiometry with PDMS, acid catalyst, and water. Particulate additives, alginate and bentonite, were added during the cross-linking process. Cationic drug lidocaine was incorporated into the adhesive with or without additive, and the time-dependent drug release profile was evaluated in phosphate buffered saline and ethanol, respectively. According to kinetic fitting to power function and parabolic diffusion, both solvent and additive type influenced drug release. In particular, particulate additives were found to suppress or facilitate drug release in water or ethanol, respectively.

Original languageEnglish
Pages (from-to)1600-1603
Number of pages4
JournalKorean Journal of Chemical Engineering
Volume34
Issue number6
DOIs
Publication statusPublished - 2017 Jun 1

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Chemical Engineering(all)

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