Controlled drug release of silicone-based adhesive-containing cross-linked siloxane powders as a reservoir

Cheol Hyun Kim, Su Jung Lee, Gyeong Hyeon Gwak, Tae Woo Kim, Hyeon Mo Cho, Jae Min Oh, Myong Euy Lee

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

We prepared pressure-sensitive adhesive (PSA)-containing cross-linked siloxane powders (CS) as a reservoir for a transdermal drug delivery system (TDDS) and evaluated their sustained drug-release properties. PSA, as a patch-type adhesive, was synthesized by a hydrosilylation reaction of vinyl-terminated polysiloxanes with hydrogen-terminated polydimethylsiloxanes. CS was also prepared via a hydrosilylation process with vinyl-terminated polydimethylsiloxane, 1,3,5,7-tetramethyl-1,3,5,7-tetravinyltetracyclosiloxane (D4Vi), hydrogen-terminated polydimethylsiloxane, and dimethylhydrogenmethyl oligomeric siloxane copolymer. The results of release performances using ascorbic acid as a model drug showed a cumulative linear slope over a week, indicating a constant release performance. Our data suggest that this siloxane TDDS could be useful for constant drug release over a long period.

Original languageEnglish
Article number42154
JournalJournal of Applied Polymer Science
Volume132
Issue number26
DOIs
Publication statusPublished - 2015 Jan 1

Fingerprint

Siloxanes
Silicones
Polydimethylsiloxane
Powders
Hydrosilylation
Adhesives
Pharmaceutical Preparations
Hydrogen
Ascorbic acid
Dimethylpolysiloxanes
Copolymers
Ascorbic Acid
Drug Delivery Systems

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Polymers and Plastics
  • Materials Chemistry

Cite this

Kim, Cheol Hyun ; Lee, Su Jung ; Gwak, Gyeong Hyeon ; Kim, Tae Woo ; Cho, Hyeon Mo ; Oh, Jae Min ; Lee, Myong Euy. / Controlled drug release of silicone-based adhesive-containing cross-linked siloxane powders as a reservoir. In: Journal of Applied Polymer Science. 2015 ; Vol. 132, No. 26.
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Controlled drug release of silicone-based adhesive-containing cross-linked siloxane powders as a reservoir. / Kim, Cheol Hyun; Lee, Su Jung; Gwak, Gyeong Hyeon; Kim, Tae Woo; Cho, Hyeon Mo; Oh, Jae Min; Lee, Myong Euy.

In: Journal of Applied Polymer Science, Vol. 132, No. 26, 42154, 01.01.2015.

Research output: Contribution to journalArticle

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