Controlled drug release of silicone-based adhesive-containing cross-linked siloxane powders as a reservoir

Cheol Hyun Kim, Su Jung Lee, Gyeong Hyeon Gwak, Tae Woo Kim, Hyeon Mo Cho, Jae Min Oh, Myong Euy Lee

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We prepared pressure-sensitive adhesive (PSA)-containing cross-linked siloxane powders (CS) as a reservoir for a transdermal drug delivery system (TDDS) and evaluated their sustained drug-release properties. PSA, as a patch-type adhesive, was synthesized by a hydrosilylation reaction of vinyl-terminated polysiloxanes with hydrogen-terminated polydimethylsiloxanes. CS was also prepared via a hydrosilylation process with vinyl-terminated polydimethylsiloxane, 1,3,5,7-tetramethyl-1,3,5,7-tetravinyltetracyclosiloxane (D4Vi), hydrogen-terminated polydimethylsiloxane, and dimethylhydrogenmethyl oligomeric siloxane copolymer. The results of release performances using ascorbic acid as a model drug showed a cumulative linear slope over a week, indicating a constant release performance. Our data suggest that this siloxane TDDS could be useful for constant drug release over a long period.

Original languageEnglish
Article number42154
JournalJournal of Applied Polymer Science
Issue number26
Publication statusPublished - 2015 Jul 1


All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Polymers and Plastics
  • Materials Chemistry

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