Controlled Support MEG imaging

Srikantan S. Nagarajan, Oleg Portniaguine, Dosik Hwang, Chris Johnson, Kensuke Sekihara

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)

Abstract

In this paper, we present a novel approach to imaging sparse and focal neural current sources from MEG (magnetoencephalography) data. Using the framework of Tikhonov regularization theory, we introduce a new stabilizer that uses the concept of controlled support to incorporate a priori assumptions about the area occupied by focal sources. The paper discusses the underlying Tikhonov theory and its relationship to a Bayesian formulation which in turn allows us to interpret and better understand other related algorithms.

Original languageEnglish
Pages (from-to)878-885
Number of pages8
JournalNeuroImage
Volume33
Issue number3
DOIs
Publication statusPublished - 2006 Nov 15

Bibliographical note

Funding Information:
This work was partially supported under NIH grant P41 RR12553-03 and also by grants from the Whitaker Foundation and NIH (R01DC004855) to S.N. The authors would like to thank Dr. M. Funke from the University of Utah Department of Radiology for his help providing the realistic MEG array geometry and Blythe Nobleman from Scientific Computing and Imaging Institute at the University of Utah, for her many useful suggestions pertaining to the manuscript.

All Science Journal Classification (ASJC) codes

  • Neurology
  • Cognitive Neuroscience

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