Controversial issues of neoadjuvant treatment in borderline resectable pancreatic cancer

Chang Moo Kang, Ho Kyoung Hwang, Sung Hoon Choi, Woo Jung Lee

Research output: Contribution to journalReview articlepeer-review

11 Citations (Scopus)

Abstract

Pancreatic ductal adenocarcinoma is known as one of the most fatal malignant diseases in gastrointestinal system. Approximately 20% of patients are deemed resectable at the time of diagnosis. Preoperative neoadjuvant therapy to the borderline resectable pancreatic cancer (BRPC) has been challenged to achieve down-staging of cancer, to avoid unnecessary major operation if the pancreatic cancer progresses and distant metastasis develops during preoperative treatment, and to avoid delayed adjuvant treatment after major operation due to postoperative complications and poor general condition after major surgery. However, there are some controversial issues influencing the clinical interpretation of surgical and oncologic outcomes of pancreatectomy following neoadjuvant treatment in managing BRPC. This manuscript reviews the current controversial issues in managing BRPC in order to enhance proper understanding the current status and potential role of neoadjuvant treatment in managing BRPC.

Original languageEnglish
Pages (from-to)123-131
Number of pages9
JournalSurgical Oncology
Volume22
Issue number2
DOIs
Publication statusPublished - 2013 Jun

All Science Journal Classification (ASJC) codes

  • Surgery
  • Oncology

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