Controversies in surveillance and early diagnosis of hepatocellular carcinoma

doyoung kim, Jin Wook Kim, Ryoko Kuromatsu, SangHoon Ahn, Takuji Torimura, Morris Sherman

Research output: Contribution to journalReview article

15 Citations (Scopus)

Abstract

The surveillance of hepatocellular carcinoma (HCC) is an established approach to detect early cancers in patients with defined risks. However, there are still varied controversies and issues to be addressed regarding the optimal surveillance methods and interval. Moreover, there are discrepancies in the opinion or practice of HCC surveillance between Eastern and Western countries. The Western strategy of ultrasound without a biomarker such as α-fetoprotein reflects the cost-effective utilization of limited resources. On the contrary, combined measurements of biomarkers in Eastern countries are based on the assumption that increased detection of early cancers could result in an overall survival benefit. To address this complicated issue, a prospective study comparing different surveillance tests might be required. More importantly, discovery of a novel biomarker with higher performance would be an alternative.

Original languageEnglish
Pages (from-to)56-60
Number of pages5
JournalOncology
Volume81
Issue numberSUPPL. 1
DOIs
Publication statusPublished - 2011 Dec 1

Fingerprint

Early Diagnosis
Hepatocellular Carcinoma
Biomarkers
Fetal Proteins
Early Detection of Cancer
Prospective Studies
Costs and Cost Analysis
Survival
Neoplasms

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

kim, D., Kim, J. W., Kuromatsu, R., Ahn, S., Torimura, T., & Sherman, M. (2011). Controversies in surveillance and early diagnosis of hepatocellular carcinoma. Oncology, 81(SUPPL. 1), 56-60. https://doi.org/10.1159/000333261
kim, doyoung ; Kim, Jin Wook ; Kuromatsu, Ryoko ; Ahn, SangHoon ; Torimura, Takuji ; Sherman, Morris. / Controversies in surveillance and early diagnosis of hepatocellular carcinoma. In: Oncology. 2011 ; Vol. 81, No. SUPPL. 1. pp. 56-60.
@article{574e3564765f478eba597b81c25d87a0,
title = "Controversies in surveillance and early diagnosis of hepatocellular carcinoma",
abstract = "The surveillance of hepatocellular carcinoma (HCC) is an established approach to detect early cancers in patients with defined risks. However, there are still varied controversies and issues to be addressed regarding the optimal surveillance methods and interval. Moreover, there are discrepancies in the opinion or practice of HCC surveillance between Eastern and Western countries. The Western strategy of ultrasound without a biomarker such as α-fetoprotein reflects the cost-effective utilization of limited resources. On the contrary, combined measurements of biomarkers in Eastern countries are based on the assumption that increased detection of early cancers could result in an overall survival benefit. To address this complicated issue, a prospective study comparing different surveillance tests might be required. More importantly, discovery of a novel biomarker with higher performance would be an alternative.",
author = "doyoung kim and Kim, {Jin Wook} and Ryoko Kuromatsu and SangHoon Ahn and Takuji Torimura and Morris Sherman",
year = "2011",
month = "12",
day = "1",
doi = "10.1159/000333261",
language = "English",
volume = "81",
pages = "56--60",
journal = "Oncology",
issn = "0030-2414",
publisher = "S. Karger AG",
number = "SUPPL. 1",

}

kim, D, Kim, JW, Kuromatsu, R, Ahn, S, Torimura, T & Sherman, M 2011, 'Controversies in surveillance and early diagnosis of hepatocellular carcinoma', Oncology, vol. 81, no. SUPPL. 1, pp. 56-60. https://doi.org/10.1159/000333261

Controversies in surveillance and early diagnosis of hepatocellular carcinoma. / kim, doyoung; Kim, Jin Wook; Kuromatsu, Ryoko; Ahn, SangHoon; Torimura, Takuji; Sherman, Morris.

In: Oncology, Vol. 81, No. SUPPL. 1, 01.12.2011, p. 56-60.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Controversies in surveillance and early diagnosis of hepatocellular carcinoma

AU - kim, doyoung

AU - Kim, Jin Wook

AU - Kuromatsu, Ryoko

AU - Ahn, SangHoon

AU - Torimura, Takuji

AU - Sherman, Morris

PY - 2011/12/1

Y1 - 2011/12/1

N2 - The surveillance of hepatocellular carcinoma (HCC) is an established approach to detect early cancers in patients with defined risks. However, there are still varied controversies and issues to be addressed regarding the optimal surveillance methods and interval. Moreover, there are discrepancies in the opinion or practice of HCC surveillance between Eastern and Western countries. The Western strategy of ultrasound without a biomarker such as α-fetoprotein reflects the cost-effective utilization of limited resources. On the contrary, combined measurements of biomarkers in Eastern countries are based on the assumption that increased detection of early cancers could result in an overall survival benefit. To address this complicated issue, a prospective study comparing different surveillance tests might be required. More importantly, discovery of a novel biomarker with higher performance would be an alternative.

AB - The surveillance of hepatocellular carcinoma (HCC) is an established approach to detect early cancers in patients with defined risks. However, there are still varied controversies and issues to be addressed regarding the optimal surveillance methods and interval. Moreover, there are discrepancies in the opinion or practice of HCC surveillance between Eastern and Western countries. The Western strategy of ultrasound without a biomarker such as α-fetoprotein reflects the cost-effective utilization of limited resources. On the contrary, combined measurements of biomarkers in Eastern countries are based on the assumption that increased detection of early cancers could result in an overall survival benefit. To address this complicated issue, a prospective study comparing different surveillance tests might be required. More importantly, discovery of a novel biomarker with higher performance would be an alternative.

UR - http://www.scopus.com/inward/record.url?scp=84855298997&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84855298997&partnerID=8YFLogxK

U2 - 10.1159/000333261

DO - 10.1159/000333261

M3 - Review article

VL - 81

SP - 56

EP - 60

JO - Oncology

JF - Oncology

SN - 0030-2414

IS - SUPPL. 1

ER -