Controversies in surveillance and early diagnosis of hepatocellular carcinoma

Do Young Kim, Jin Wook Kim, Ryoko Kuromatsu, Sang Hoon Ahn, Takuji Torimura, Morris Sherman

Research output: Contribution to journalReview article

15 Citations (Scopus)

Abstract

The surveillance of hepatocellular carcinoma (HCC) is an established approach to detect early cancers in patients with defined risks. However, there are still varied controversies and issues to be addressed regarding the optimal surveillance methods and interval. Moreover, there are discrepancies in the opinion or practice of HCC surveillance between Eastern and Western countries. The Western strategy of ultrasound without a biomarker such as α-fetoprotein reflects the cost-effective utilization of limited resources. On the contrary, combined measurements of biomarkers in Eastern countries are based on the assumption that increased detection of early cancers could result in an overall survival benefit. To address this complicated issue, a prospective study comparing different surveillance tests might be required. More importantly, discovery of a novel biomarker with higher performance would be an alternative.

Original languageEnglish
Pages (from-to)56-60
Number of pages5
JournalOncology
Volume81
Issue numberSUPPL. 1
DOIs
Publication statusPublished - 2011 Dec

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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