Conventional endoscopic features are not sufficient to differentiate small, early colorectal cancer

Wan Park, Bun Kim, Soo Jung Park, JaeHee Cheon, Tae Il Kim, Won Ho Kim, Sung Pil Hong

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

AIM: To evaluate the depth of invasion of small, early colorectal cancers (ECCs) using conventional endoscopic features. METHODS: From January 2005 to September 2011, colonoscopy cohort showed that a total of 72 patients with small colorectal cancers with the size less than 20 mm underwent colonoscopy at the Yonsei University College of Medicine, Seoul, South Korea. Among them, 8 patients were excluded due to incomplete medical records. Finally, a total of 64 ECCs with submucosa (SM) invasion and size less than 20 mm were included. One hundred fifty-two adenomas with size less than 20 mm were included as controls. Nine endoscopic features, including seven morphological findings (i.e., loss of lobulation, excavation, demarcated and depressed areas, stalk swelling, fullness, fold convergence, and bleeding ulcers), pit patterns, and non-lifting signs, were evalu-evaluated retrospectively. All endoscopic features were evaluated by two experienced endoscopists who have each performed over 1000 colonoscopies annually for more than five years without knowledge of the histology. RESULTS: Among the morphological findings, the size of deep submucosal cancers was bigger than that of superficial lesions (16.9 mm vs 12.3 mm, P < 0.001). Also, demarcated depressed areas, stalk swelling, and fullness were more common in deep SM cancers than in superficial tumors (demarcated depressed areas: 52.0% vs 15.7%, P < 0.001; stalk swelling: 100% vs 4.2%, P < 0.001; fullness: 25.0% vs 0%, P = 0.001). Among deep SM cancers, 96% of polyps showed invasive pit patterns, whereas 19.4% of superficial tumors showed invasive pit patterns (P < 0.001). A positive non-lifting sign was more common in deep SM cancers (85.0% vs 28.6%, P < 0.001). Diagnostic accuracy of invasive morphology, invasive pit patterns, and nonlifting signs for deep SM cancers were 71%, 82%, and 75%, respectively. CONCLUSION: Conventional endoscopic findings were insufficient to discriminate small, deep SM cancers from superficial SM cancers by white light, standard colonoscopy.

Original languageEnglish
Pages (from-to)6586-6593
Number of pages8
JournalWorld Journal of Gastroenterology
Volume20
Issue number21
DOIs
Publication statusPublished - 2014 Jan 1

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Colorectal Neoplasms
Colonoscopy
Neoplasms
Republic of Korea
Polyps
Adenoma
Ulcer
Medical Records
Histology
Medicine
Hemorrhage
Light

All Science Journal Classification (ASJC) codes

  • Gastroenterology

Cite this

Park, Wan ; Kim, Bun ; Park, Soo Jung ; Cheon, JaeHee ; Kim, Tae Il ; Kim, Won Ho ; Hong, Sung Pil. / Conventional endoscopic features are not sufficient to differentiate small, early colorectal cancer. In: World Journal of Gastroenterology. 2014 ; Vol. 20, No. 21. pp. 6586-6593.
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abstract = "AIM: To evaluate the depth of invasion of small, early colorectal cancers (ECCs) using conventional endoscopic features. METHODS: From January 2005 to September 2011, colonoscopy cohort showed that a total of 72 patients with small colorectal cancers with the size less than 20 mm underwent colonoscopy at the Yonsei University College of Medicine, Seoul, South Korea. Among them, 8 patients were excluded due to incomplete medical records. Finally, a total of 64 ECCs with submucosa (SM) invasion and size less than 20 mm were included. One hundred fifty-two adenomas with size less than 20 mm were included as controls. Nine endoscopic features, including seven morphological findings (i.e., loss of lobulation, excavation, demarcated and depressed areas, stalk swelling, fullness, fold convergence, and bleeding ulcers), pit patterns, and non-lifting signs, were evalu-evaluated retrospectively. All endoscopic features were evaluated by two experienced endoscopists who have each performed over 1000 colonoscopies annually for more than five years without knowledge of the histology. RESULTS: Among the morphological findings, the size of deep submucosal cancers was bigger than that of superficial lesions (16.9 mm vs 12.3 mm, P < 0.001). Also, demarcated depressed areas, stalk swelling, and fullness were more common in deep SM cancers than in superficial tumors (demarcated depressed areas: 52.0{\%} vs 15.7{\%}, P < 0.001; stalk swelling: 100{\%} vs 4.2{\%}, P < 0.001; fullness: 25.0{\%} vs 0{\%}, P = 0.001). Among deep SM cancers, 96{\%} of polyps showed invasive pit patterns, whereas 19.4{\%} of superficial tumors showed invasive pit patterns (P < 0.001). A positive non-lifting sign was more common in deep SM cancers (85.0{\%} vs 28.6{\%}, P < 0.001). Diagnostic accuracy of invasive morphology, invasive pit patterns, and nonlifting signs for deep SM cancers were 71{\%}, 82{\%}, and 75{\%}, respectively. CONCLUSION: Conventional endoscopic findings were insufficient to discriminate small, deep SM cancers from superficial SM cancers by white light, standard colonoscopy.",
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Conventional endoscopic features are not sufficient to differentiate small, early colorectal cancer. / Park, Wan; Kim, Bun; Park, Soo Jung; Cheon, JaeHee; Kim, Tae Il; Kim, Won Ho; Hong, Sung Pil.

In: World Journal of Gastroenterology, Vol. 20, No. 21, 01.01.2014, p. 6586-6593.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Conventional endoscopic features are not sufficient to differentiate small, early colorectal cancer

AU - Park, Wan

AU - Kim, Bun

AU - Park, Soo Jung

AU - Cheon, JaeHee

AU - Kim, Tae Il

AU - Kim, Won Ho

AU - Hong, Sung Pil

PY - 2014/1/1

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N2 - AIM: To evaluate the depth of invasion of small, early colorectal cancers (ECCs) using conventional endoscopic features. METHODS: From January 2005 to September 2011, colonoscopy cohort showed that a total of 72 patients with small colorectal cancers with the size less than 20 mm underwent colonoscopy at the Yonsei University College of Medicine, Seoul, South Korea. Among them, 8 patients were excluded due to incomplete medical records. Finally, a total of 64 ECCs with submucosa (SM) invasion and size less than 20 mm were included. One hundred fifty-two adenomas with size less than 20 mm were included as controls. Nine endoscopic features, including seven morphological findings (i.e., loss of lobulation, excavation, demarcated and depressed areas, stalk swelling, fullness, fold convergence, and bleeding ulcers), pit patterns, and non-lifting signs, were evalu-evaluated retrospectively. All endoscopic features were evaluated by two experienced endoscopists who have each performed over 1000 colonoscopies annually for more than five years without knowledge of the histology. RESULTS: Among the morphological findings, the size of deep submucosal cancers was bigger than that of superficial lesions (16.9 mm vs 12.3 mm, P < 0.001). Also, demarcated depressed areas, stalk swelling, and fullness were more common in deep SM cancers than in superficial tumors (demarcated depressed areas: 52.0% vs 15.7%, P < 0.001; stalk swelling: 100% vs 4.2%, P < 0.001; fullness: 25.0% vs 0%, P = 0.001). Among deep SM cancers, 96% of polyps showed invasive pit patterns, whereas 19.4% of superficial tumors showed invasive pit patterns (P < 0.001). A positive non-lifting sign was more common in deep SM cancers (85.0% vs 28.6%, P < 0.001). Diagnostic accuracy of invasive morphology, invasive pit patterns, and nonlifting signs for deep SM cancers were 71%, 82%, and 75%, respectively. CONCLUSION: Conventional endoscopic findings were insufficient to discriminate small, deep SM cancers from superficial SM cancers by white light, standard colonoscopy.

AB - AIM: To evaluate the depth of invasion of small, early colorectal cancers (ECCs) using conventional endoscopic features. METHODS: From January 2005 to September 2011, colonoscopy cohort showed that a total of 72 patients with small colorectal cancers with the size less than 20 mm underwent colonoscopy at the Yonsei University College of Medicine, Seoul, South Korea. Among them, 8 patients were excluded due to incomplete medical records. Finally, a total of 64 ECCs with submucosa (SM) invasion and size less than 20 mm were included. One hundred fifty-two adenomas with size less than 20 mm were included as controls. Nine endoscopic features, including seven morphological findings (i.e., loss of lobulation, excavation, demarcated and depressed areas, stalk swelling, fullness, fold convergence, and bleeding ulcers), pit patterns, and non-lifting signs, were evalu-evaluated retrospectively. All endoscopic features were evaluated by two experienced endoscopists who have each performed over 1000 colonoscopies annually for more than five years without knowledge of the histology. RESULTS: Among the morphological findings, the size of deep submucosal cancers was bigger than that of superficial lesions (16.9 mm vs 12.3 mm, P < 0.001). Also, demarcated depressed areas, stalk swelling, and fullness were more common in deep SM cancers than in superficial tumors (demarcated depressed areas: 52.0% vs 15.7%, P < 0.001; stalk swelling: 100% vs 4.2%, P < 0.001; fullness: 25.0% vs 0%, P = 0.001). Among deep SM cancers, 96% of polyps showed invasive pit patterns, whereas 19.4% of superficial tumors showed invasive pit patterns (P < 0.001). A positive non-lifting sign was more common in deep SM cancers (85.0% vs 28.6%, P < 0.001). Diagnostic accuracy of invasive morphology, invasive pit patterns, and nonlifting signs for deep SM cancers were 71%, 82%, and 75%, respectively. CONCLUSION: Conventional endoscopic findings were insufficient to discriminate small, deep SM cancers from superficial SM cancers by white light, standard colonoscopy.

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