Cooperative Multifunctional Self-Propelled Paramagnetic Microrobots with Chemical Handles for Cell Manipulation and Drug Delivery

Katherine Villa, Ludmila Krejčová, Filip Novotný, Zbynek Heger, Zdeněk Sofer, Martin Pumera

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Autonomous self-propelled micromachines, taking energy from surrounding environment and converting it to their motion, are on the forefront of the research for smart materials in the recent years. Owing to their self-propulsion mechanism, they have demonstrated to be more efficient drug carriers than passive particles. Here, multifunctional superparamagnetic/catalytic microrobots (PM/Pt microrobots) for cell manipulation, anticancer drug loading, and delivery to breast cancer cells are presented. These PM/Pt microrobots are fabricated from superparamagnetic polymer particles with iron oxide in their interior and an external tosylated surface, which is half-covered by a catalytic platinum (Pt) layer. This result in a triple-functionality—tosyl group-rich polymer layer can bind molecules and biological materials, Pt layer can catalyze decomposition of hydrogen peroxide, providing propulsion to the microrobots and magnetic part allows for manipulation by magnetic field. PM/Pt microrobots are able to move as individual robots and to “team-up” under influence of weak magnetic field by forming chains of the micromachines to perform collective actions, such as capture and transportation of cancer cells. The efficacy of PM/Pt microrobots to perform several tasks without complex surface functionalization steps simplifies the applicability of such multifunctional devices toward diverse biomedical applications.

Original languageEnglish
Article number1804343
JournalAdvanced Functional Materials
Volume28
Issue number43
DOIs
Publication statusPublished - 2018 Oct 24

Fingerprint

Platinum
Drug delivery
manipulators
delivery
drugs
platinum
cells
propulsion
Propulsion
Polymers
cancer
Cells
Magnetic fields
Drug Carriers
smart materials
Intelligent materials
polymers
hydrogen peroxide
robots
Iron oxides

All Science Journal Classification (ASJC) codes

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Chemistry(all)
  • Materials Science(all)
  • Condensed Matter Physics
  • Electrochemistry

Cite this

Villa, Katherine ; Krejčová, Ludmila ; Novotný, Filip ; Heger, Zbynek ; Sofer, Zdeněk ; Pumera, Martin. / Cooperative Multifunctional Self-Propelled Paramagnetic Microrobots with Chemical Handles for Cell Manipulation and Drug Delivery. In: Advanced Functional Materials. 2018 ; Vol. 28, No. 43.
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Cooperative Multifunctional Self-Propelled Paramagnetic Microrobots with Chemical Handles for Cell Manipulation and Drug Delivery. / Villa, Katherine; Krejčová, Ludmila; Novotný, Filip; Heger, Zbynek; Sofer, Zdeněk; Pumera, Martin.

In: Advanced Functional Materials, Vol. 28, No. 43, 1804343, 24.10.2018.

Research output: Contribution to journalArticle

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