Coronal plane spinal malalignment and Parkinson's disease: Prevalence and associations with disease severity

Hong June Choi, Justin S. Smith, Christopher I. Shaffrey, Virginie C. Lafage, Frank J. Schwab, Christopher P. Ames, Morio Matsumoto, Jong Sam Baik, Yoon Ha

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Background context Parkinson's disease (PD) is a progressive degenerative disorder of the central nervous system. Patients with PD often present with abnormal posturing.

Purpose To investigate coronal plane deformities in patients with PD, and to evaluate the correlation between clinical features, coronal parameters related to spine alignment, and disease severity.

Study design A cross-sectional study.

Patient sample Eighty-nine patients with PD and 89 controls were included.

Outcome measures A medical history was collected from the medical records.

Methods This study was a prospective assessment of consecutive patients with PD. Clinical and demographic parameters were collected from medical records and outpatient interviews. Full-length standing anteroposterior and lateral spine radiographs were used to assess the spinal parameters. The threshold for scoliosis was set at a 10° Cobb angle, and the curve type was classified using Schwab classification.

Results A total of 178 patients (89 in PD and 89 in control groups) were included. Scoliosis was identified in 27 patients (30%) and 22 controls (p=.502). However, coronal imbalance was more common in patients with PD than in controls (11 vs. 0 patients, p=.001). Scoliosis was more common in women than in men (male:female=8:19, p=.04). Back pain was more common in patients with scoliosis than in those without scoliosis (14 of 27 vs. 17 of 62, p=.036). Schwab Type IV (thoracolumbar major) was the most common type of scoliosis in patients with PD and Type V (lumbar major) was the most common type in controls. With adjustment for patient age and gender, multiple linear regression analysis revealed that severity of PD (Unified Parkinson's Disease Rating Scale, p=.037) and magnitude of global coronal malalignment (p=.003) were associated with the scoliosis Cobb angle (p=.037, B=0.139). Direction of scoliosis and side of global coronal malalignment were not significantly correlated with the laterality of predominant PD symptoms (p>.05).

Conclusions Global coronal malalignment is more prevalent in patients with PD than in controls. Greater severity of PD was significantly associated with greater magnitude of scoliosis Cobb angle, even after adjusting for the effects of patient age and gender. However, direction of scoliosis and side of global coronal malalignment were not significantly associated with the dominant laterality of PD symptoms.

Original languageEnglish
Pages (from-to)115-121
Number of pages7
JournalSpine Journal
Volume15
Issue number1
DOIs
Publication statusPublished - 2015 Jan 1

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Spinal Diseases
Parkinson Disease
Scoliosis
Medical Records
Spine
Central Nervous System Diseases
Back Pain

All Science Journal Classification (ASJC) codes

  • Surgery
  • Clinical Neurology

Cite this

Choi, Hong June ; Smith, Justin S. ; Shaffrey, Christopher I. ; Lafage, Virginie C. ; Schwab, Frank J. ; Ames, Christopher P. ; Matsumoto, Morio ; Baik, Jong Sam ; Ha, Yoon. / Coronal plane spinal malalignment and Parkinson's disease : Prevalence and associations with disease severity. In: Spine Journal. 2015 ; Vol. 15, No. 1. pp. 115-121.
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title = "Coronal plane spinal malalignment and Parkinson's disease: Prevalence and associations with disease severity",
abstract = "Background context Parkinson's disease (PD) is a progressive degenerative disorder of the central nervous system. Patients with PD often present with abnormal posturing.Purpose To investigate coronal plane deformities in patients with PD, and to evaluate the correlation between clinical features, coronal parameters related to spine alignment, and disease severity.Study design A cross-sectional study.Patient sample Eighty-nine patients with PD and 89 controls were included.Outcome measures A medical history was collected from the medical records.Methods This study was a prospective assessment of consecutive patients with PD. Clinical and demographic parameters were collected from medical records and outpatient interviews. Full-length standing anteroposterior and lateral spine radiographs were used to assess the spinal parameters. The threshold for scoliosis was set at a 10° Cobb angle, and the curve type was classified using Schwab classification.Results A total of 178 patients (89 in PD and 89 in control groups) were included. Scoliosis was identified in 27 patients (30{\%}) and 22 controls (p=.502). However, coronal imbalance was more common in patients with PD than in controls (11 vs. 0 patients, p=.001). Scoliosis was more common in women than in men (male:female=8:19, p=.04). Back pain was more common in patients with scoliosis than in those without scoliosis (14 of 27 vs. 17 of 62, p=.036). Schwab Type IV (thoracolumbar major) was the most common type of scoliosis in patients with PD and Type V (lumbar major) was the most common type in controls. With adjustment for patient age and gender, multiple linear regression analysis revealed that severity of PD (Unified Parkinson's Disease Rating Scale, p=.037) and magnitude of global coronal malalignment (p=.003) were associated with the scoliosis Cobb angle (p=.037, B=0.139). Direction of scoliosis and side of global coronal malalignment were not significantly correlated with the laterality of predominant PD symptoms (p>.05).Conclusions Global coronal malalignment is more prevalent in patients with PD than in controls. Greater severity of PD was significantly associated with greater magnitude of scoliosis Cobb angle, even after adjusting for the effects of patient age and gender. However, direction of scoliosis and side of global coronal malalignment were not significantly associated with the dominant laterality of PD symptoms.",
author = "Choi, {Hong June} and Smith, {Justin S.} and Shaffrey, {Christopher I.} and Lafage, {Virginie C.} and Schwab, {Frank J.} and Ames, {Christopher P.} and Morio Matsumoto and Baik, {Jong Sam} and Yoon Ha",
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Choi, HJ, Smith, JS, Shaffrey, CI, Lafage, VC, Schwab, FJ, Ames, CP, Matsumoto, M, Baik, JS & Ha, Y 2015, 'Coronal plane spinal malalignment and Parkinson's disease: Prevalence and associations with disease severity', Spine Journal, vol. 15, no. 1, pp. 115-121. https://doi.org/10.1016/j.spinee.2014.07.004

Coronal plane spinal malalignment and Parkinson's disease : Prevalence and associations with disease severity. / Choi, Hong June; Smith, Justin S.; Shaffrey, Christopher I.; Lafage, Virginie C.; Schwab, Frank J.; Ames, Christopher P.; Matsumoto, Morio; Baik, Jong Sam; Ha, Yoon.

In: Spine Journal, Vol. 15, No. 1, 01.01.2015, p. 115-121.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Coronal plane spinal malalignment and Parkinson's disease

T2 - Prevalence and associations with disease severity

AU - Choi, Hong June

AU - Smith, Justin S.

AU - Shaffrey, Christopher I.

AU - Lafage, Virginie C.

AU - Schwab, Frank J.

AU - Ames, Christopher P.

AU - Matsumoto, Morio

AU - Baik, Jong Sam

AU - Ha, Yoon

PY - 2015/1/1

Y1 - 2015/1/1

N2 - Background context Parkinson's disease (PD) is a progressive degenerative disorder of the central nervous system. Patients with PD often present with abnormal posturing.Purpose To investigate coronal plane deformities in patients with PD, and to evaluate the correlation between clinical features, coronal parameters related to spine alignment, and disease severity.Study design A cross-sectional study.Patient sample Eighty-nine patients with PD and 89 controls were included.Outcome measures A medical history was collected from the medical records.Methods This study was a prospective assessment of consecutive patients with PD. Clinical and demographic parameters were collected from medical records and outpatient interviews. Full-length standing anteroposterior and lateral spine radiographs were used to assess the spinal parameters. The threshold for scoliosis was set at a 10° Cobb angle, and the curve type was classified using Schwab classification.Results A total of 178 patients (89 in PD and 89 in control groups) were included. Scoliosis was identified in 27 patients (30%) and 22 controls (p=.502). However, coronal imbalance was more common in patients with PD than in controls (11 vs. 0 patients, p=.001). Scoliosis was more common in women than in men (male:female=8:19, p=.04). Back pain was more common in patients with scoliosis than in those without scoliosis (14 of 27 vs. 17 of 62, p=.036). Schwab Type IV (thoracolumbar major) was the most common type of scoliosis in patients with PD and Type V (lumbar major) was the most common type in controls. With adjustment for patient age and gender, multiple linear regression analysis revealed that severity of PD (Unified Parkinson's Disease Rating Scale, p=.037) and magnitude of global coronal malalignment (p=.003) were associated with the scoliosis Cobb angle (p=.037, B=0.139). Direction of scoliosis and side of global coronal malalignment were not significantly correlated with the laterality of predominant PD symptoms (p>.05).Conclusions Global coronal malalignment is more prevalent in patients with PD than in controls. Greater severity of PD was significantly associated with greater magnitude of scoliosis Cobb angle, even after adjusting for the effects of patient age and gender. However, direction of scoliosis and side of global coronal malalignment were not significantly associated with the dominant laterality of PD symptoms.

AB - Background context Parkinson's disease (PD) is a progressive degenerative disorder of the central nervous system. Patients with PD often present with abnormal posturing.Purpose To investigate coronal plane deformities in patients with PD, and to evaluate the correlation between clinical features, coronal parameters related to spine alignment, and disease severity.Study design A cross-sectional study.Patient sample Eighty-nine patients with PD and 89 controls were included.Outcome measures A medical history was collected from the medical records.Methods This study was a prospective assessment of consecutive patients with PD. Clinical and demographic parameters were collected from medical records and outpatient interviews. Full-length standing anteroposterior and lateral spine radiographs were used to assess the spinal parameters. The threshold for scoliosis was set at a 10° Cobb angle, and the curve type was classified using Schwab classification.Results A total of 178 patients (89 in PD and 89 in control groups) were included. Scoliosis was identified in 27 patients (30%) and 22 controls (p=.502). However, coronal imbalance was more common in patients with PD than in controls (11 vs. 0 patients, p=.001). Scoliosis was more common in women than in men (male:female=8:19, p=.04). Back pain was more common in patients with scoliosis than in those without scoliosis (14 of 27 vs. 17 of 62, p=.036). Schwab Type IV (thoracolumbar major) was the most common type of scoliosis in patients with PD and Type V (lumbar major) was the most common type in controls. With adjustment for patient age and gender, multiple linear regression analysis revealed that severity of PD (Unified Parkinson's Disease Rating Scale, p=.037) and magnitude of global coronal malalignment (p=.003) were associated with the scoliosis Cobb angle (p=.037, B=0.139). Direction of scoliosis and side of global coronal malalignment were not significantly correlated with the laterality of predominant PD symptoms (p>.05).Conclusions Global coronal malalignment is more prevalent in patients with PD than in controls. Greater severity of PD was significantly associated with greater magnitude of scoliosis Cobb angle, even after adjusting for the effects of patient age and gender. However, direction of scoliosis and side of global coronal malalignment were not significantly associated with the dominant laterality of PD symptoms.

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