Coronary artery calcification in Korean patients with incident dialysis

Eunjin Bae, Eun Yong Seong, Byoung Geun Han, Dong Ki Kim, Chun Soo Lim, Shin Wook Kang, Cheol Whee Park, Chan Duck Kim, Byung Chul Shin, Sung Gyun Kim, Wookyung Chung, Jae Yoon Park, Joo Yeon Lee, Yon Su Kim

Research output: Contribution to journalArticle

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Abstract

Introduction: Patients with chronic kidney disease have an extremely high risk of developing cardiovascular disease (CVD). In patients with end-stage renal disease (ESRD), coronary artery calcification (CAC) is associated with increased mortality from CVD. Methods: The present study aimed to investigate the risk factors for CAC in Korean patients with incident dialysis. Data on 423 patients with ESRD who started dialysis therapy between December 2012 and March 2014 were obtained from 10 university-affiliated hospitals. CAC was identified by using noncontrast-enhanced cardiac multidetector computed tomography. The CAC score was calculated according to the Agatston score, with CAC-positive subjects defined by an Agatston score >0. Findings: Patients' mean age was 55.6 ± 14.6 years, and 64.1% were men. The CAC-positive rate was 63.8% (270 of 423). Results of univariate analyses showed significant differences in age, sex, etiology of ESRD and comorbid conditions according to the CAC score. However, results of multiple regression analysis showed that only a higher age was significantly associated with the CAC score. Receiver operating characteristic curves showed that the sensitivity and specificity of L-spine radiography for diagnosing CAC were 56% and 91%, respectively, for diagnosing CAC (area under the curve, 0.735). Discussion: CAC was frequent in patients with incident dialysis, and multiple regression analysis showed that only age was significantly associated with the CAC score. In addition, L-spine radiography could be a helpful modality for diagnosing CAC in patients with incident dialysis.

Original languageEnglish
Pages (from-to)367-374
Number of pages8
JournalHemodialysis International
Volume21
Issue number3
DOIs
Publication statusPublished - 2017 Jul

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Dialysis
Coronary Vessels
Chronic Kidney Failure
Radiography
Spine
Cardiovascular Diseases
Regression Analysis
Multidetector Computed Tomography
Chronic Renal Insufficiency
ROC Curve
Area Under Curve
Sensitivity and Specificity
Mortality

All Science Journal Classification (ASJC) codes

  • Hematology
  • Nephrology

Cite this

Bae, E., Seong, E. Y., Han, B. G., Kim, D. K., Lim, C. S., Kang, S. W., ... Kim, Y. S. (2017). Coronary artery calcification in Korean patients with incident dialysis. Hemodialysis International, 21(3), 367-374. https://doi.org/10.1111/hdi.12493
Bae, Eunjin ; Seong, Eun Yong ; Han, Byoung Geun ; Kim, Dong Ki ; Lim, Chun Soo ; Kang, Shin Wook ; Park, Cheol Whee ; Kim, Chan Duck ; Shin, Byung Chul ; Kim, Sung Gyun ; Chung, Wookyung ; Park, Jae Yoon ; Lee, Joo Yeon ; Kim, Yon Su. / Coronary artery calcification in Korean patients with incident dialysis. In: Hemodialysis International. 2017 ; Vol. 21, No. 3. pp. 367-374.
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title = "Coronary artery calcification in Korean patients with incident dialysis",
abstract = "Introduction: Patients with chronic kidney disease have an extremely high risk of developing cardiovascular disease (CVD). In patients with end-stage renal disease (ESRD), coronary artery calcification (CAC) is associated with increased mortality from CVD. Methods: The present study aimed to investigate the risk factors for CAC in Korean patients with incident dialysis. Data on 423 patients with ESRD who started dialysis therapy between December 2012 and March 2014 were obtained from 10 university-affiliated hospitals. CAC was identified by using noncontrast-enhanced cardiac multidetector computed tomography. The CAC score was calculated according to the Agatston score, with CAC-positive subjects defined by an Agatston score >0. Findings: Patients' mean age was 55.6 ± 14.6 years, and 64.1{\%} were men. The CAC-positive rate was 63.8{\%} (270 of 423). Results of univariate analyses showed significant differences in age, sex, etiology of ESRD and comorbid conditions according to the CAC score. However, results of multiple regression analysis showed that only a higher age was significantly associated with the CAC score. Receiver operating characteristic curves showed that the sensitivity and specificity of L-spine radiography for diagnosing CAC were 56{\%} and 91{\%}, respectively, for diagnosing CAC (area under the curve, 0.735). Discussion: CAC was frequent in patients with incident dialysis, and multiple regression analysis showed that only age was significantly associated with the CAC score. In addition, L-spine radiography could be a helpful modality for diagnosing CAC in patients with incident dialysis.",
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Bae, E, Seong, EY, Han, BG, Kim, DK, Lim, CS, Kang, SW, Park, CW, Kim, CD, Shin, BC, Kim, SG, Chung, W, Park, JY, Lee, JY & Kim, YS 2017, 'Coronary artery calcification in Korean patients with incident dialysis', Hemodialysis International, vol. 21, no. 3, pp. 367-374. https://doi.org/10.1111/hdi.12493

Coronary artery calcification in Korean patients with incident dialysis. / Bae, Eunjin; Seong, Eun Yong; Han, Byoung Geun; Kim, Dong Ki; Lim, Chun Soo; Kang, Shin Wook; Park, Cheol Whee; Kim, Chan Duck; Shin, Byung Chul; Kim, Sung Gyun; Chung, Wookyung; Park, Jae Yoon; Lee, Joo Yeon; Kim, Yon Su.

In: Hemodialysis International, Vol. 21, No. 3, 07.2017, p. 367-374.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Coronary artery calcification in Korean patients with incident dialysis

AU - Bae, Eunjin

AU - Seong, Eun Yong

AU - Han, Byoung Geun

AU - Kim, Dong Ki

AU - Lim, Chun Soo

AU - Kang, Shin Wook

AU - Park, Cheol Whee

AU - Kim, Chan Duck

AU - Shin, Byung Chul

AU - Kim, Sung Gyun

AU - Chung, Wookyung

AU - Park, Jae Yoon

AU - Lee, Joo Yeon

AU - Kim, Yon Su

PY - 2017/7

Y1 - 2017/7

N2 - Introduction: Patients with chronic kidney disease have an extremely high risk of developing cardiovascular disease (CVD). In patients with end-stage renal disease (ESRD), coronary artery calcification (CAC) is associated with increased mortality from CVD. Methods: The present study aimed to investigate the risk factors for CAC in Korean patients with incident dialysis. Data on 423 patients with ESRD who started dialysis therapy between December 2012 and March 2014 were obtained from 10 university-affiliated hospitals. CAC was identified by using noncontrast-enhanced cardiac multidetector computed tomography. The CAC score was calculated according to the Agatston score, with CAC-positive subjects defined by an Agatston score >0. Findings: Patients' mean age was 55.6 ± 14.6 years, and 64.1% were men. The CAC-positive rate was 63.8% (270 of 423). Results of univariate analyses showed significant differences in age, sex, etiology of ESRD and comorbid conditions according to the CAC score. However, results of multiple regression analysis showed that only a higher age was significantly associated with the CAC score. Receiver operating characteristic curves showed that the sensitivity and specificity of L-spine radiography for diagnosing CAC were 56% and 91%, respectively, for diagnosing CAC (area under the curve, 0.735). Discussion: CAC was frequent in patients with incident dialysis, and multiple regression analysis showed that only age was significantly associated with the CAC score. In addition, L-spine radiography could be a helpful modality for diagnosing CAC in patients with incident dialysis.

AB - Introduction: Patients with chronic kidney disease have an extremely high risk of developing cardiovascular disease (CVD). In patients with end-stage renal disease (ESRD), coronary artery calcification (CAC) is associated with increased mortality from CVD. Methods: The present study aimed to investigate the risk factors for CAC in Korean patients with incident dialysis. Data on 423 patients with ESRD who started dialysis therapy between December 2012 and March 2014 were obtained from 10 university-affiliated hospitals. CAC was identified by using noncontrast-enhanced cardiac multidetector computed tomography. The CAC score was calculated according to the Agatston score, with CAC-positive subjects defined by an Agatston score >0. Findings: Patients' mean age was 55.6 ± 14.6 years, and 64.1% were men. The CAC-positive rate was 63.8% (270 of 423). Results of univariate analyses showed significant differences in age, sex, etiology of ESRD and comorbid conditions according to the CAC score. However, results of multiple regression analysis showed that only a higher age was significantly associated with the CAC score. Receiver operating characteristic curves showed that the sensitivity and specificity of L-spine radiography for diagnosing CAC were 56% and 91%, respectively, for diagnosing CAC (area under the curve, 0.735). Discussion: CAC was frequent in patients with incident dialysis, and multiple regression analysis showed that only age was significantly associated with the CAC score. In addition, L-spine radiography could be a helpful modality for diagnosing CAC in patients with incident dialysis.

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