Coronary artery intervention after cytostatics treatment in unstable angina patient with essential thrombocythemia. A case report and literature review

Hyun Chang, Chi Young Shim, June Won Cheong, Ju Yeon Pyo, Young Guk Ko, Donghoon Choi, Yangsoo Jang

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Essential thrombocythemia (ET) is a clonal disorder of myeloid stem cells that causes thrombocytosis. As a result, ET can lead to vascular thrombosis and tissue ischemia; the association of coronary artery abnormalities such as myocardial infarction or unstable angina is rare. Here we describe a 45-year-old male patient with essential thrombocythemia who presented with unstable angina. Elective coronary angiography showed total occlusion of mid right coronary artery and mid left anterior descending coronary artery. ET was confirmed by a bone marrow biopsy; treatment was started with antiplatelet therapy including aspirin and clopidogrel along with cytostatic therapy with hydroxyurea and anagrelide. After the initiation of the treatment, the platelet count decreased to 20 × 10 4 /μL. In addition, percutaneous coronary angioplasty was successfully performed with stent placement at the right coronary artery without hemorrhagic or thrombotic complications.

Original languageEnglish
Pages (from-to)146-149
Number of pages4
JournalKorean Journal of Internal Medicine
Volume21
Issue number2
DOIs
Publication statusPublished - 2006 Jun

Fingerprint

Essential Thrombocythemia
Unstable Angina
Cytostatic Agents
Coronary Vessels
clopidogrel
Myeloid Progenitor Cells
Thrombocytosis
Hydroxyurea
Therapeutics
Coronary Angiography
Platelet Count
Angioplasty
Aspirin
Stents
Blood Vessels
Thrombosis
Ischemia
Bone Marrow
Myocardial Infarction
Biopsy

All Science Journal Classification (ASJC) codes

  • Internal Medicine

Cite this

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abstract = "Essential thrombocythemia (ET) is a clonal disorder of myeloid stem cells that causes thrombocytosis. As a result, ET can lead to vascular thrombosis and tissue ischemia; the association of coronary artery abnormalities such as myocardial infarction or unstable angina is rare. Here we describe a 45-year-old male patient with essential thrombocythemia who presented with unstable angina. Elective coronary angiography showed total occlusion of mid right coronary artery and mid left anterior descending coronary artery. ET was confirmed by a bone marrow biopsy; treatment was started with antiplatelet therapy including aspirin and clopidogrel along with cytostatic therapy with hydroxyurea and anagrelide. After the initiation of the treatment, the platelet count decreased to 20 × 10 4 /μL. In addition, percutaneous coronary angioplasty was successfully performed with stent placement at the right coronary artery without hemorrhagic or thrombotic complications.",
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Coronary artery intervention after cytostatics treatment in unstable angina patient with essential thrombocythemia. A case report and literature review. / Chang, Hyun; Shim, Chi Young; Cheong, June Won; Pyo, Ju Yeon; Ko, Young Guk; Choi, Donghoon; Jang, Yangsoo.

In: Korean Journal of Internal Medicine, Vol. 21, No. 2, 06.2006, p. 146-149.

Research output: Contribution to journalArticle

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