Coronary atherosclerosis detected by coronary CT angiography in asymptomatic subjects with early chronic kidney disease

Iksung Cho, Hee Suk Min, Eun Ju Chun, Sue K. Park, Yunhee Choi, Roger S. Blumenthal, Juan J. Rivera, Khurram Nasir, Yong Jin Kim, Dae Won Sohn, Byung Hee Oh, Young Bae Park, Hyuk-Jae Chang

Research output: Contribution to journalArticle

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Abstract

Objectives: The purpose of this study is to assess the independent association between early CKD (stages 1-3a) with coronary atherosclerosis and the feasibility of risk stratification of coronary atherosclerosis according to The Kidney Disease Outcomes Quality Initiative (K/DOQI) guidelines using non-invasive coronary angiography. Methods: We consecutively enrolled 4297 asymptomatic subjects who underwent coronary CT angiography as part of a general health evaluation and had estimated glomerular filtration rates (eGFR) over 45 ml/min/1.73 m2. Subjects were categorized from no CKD to stage 3a CKD, and multiple regression analyses for coronary atherosclerosis were performed. Results: Early CKD was an independent risk factor for coronary artery disease (CAD) and obstructive CAD. However, neither the risk of CAD nor CACS >100 increased as stage of CKD advanced. The reason for unsuccessful stratification of coronary atherosclerosis risk was that the presence of proteinuria, which was used to define stages 1 and 2 CKD, was an independent risk factor for coronary atherosclerosis, but eGFR of 45-89 ml/min/1.73 m2 was not associated with coronary atherosclerosis. Conclusions: Early CKD was an independent risk factor for coronary atherosclerosis, and the risk stratification for coronary atherosclerosis should be based on the presence of proteinuria rather than decreased eGFR within early CKD.

Original languageEnglish
Pages (from-to)406-411
Number of pages6
JournalAtherosclerosis
Volume208
Issue number2
DOIs
Publication statusPublished - 2010 Feb 1

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Coronary Angiography
Chronic Renal Insufficiency
Coronary Artery Disease
Glomerular Filtration Rate
Proteinuria
Computed Tomography Angiography
Kidney Diseases
Regression Analysis
Guidelines

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Cho, Iksung ; Min, Hee Suk ; Chun, Eun Ju ; Park, Sue K. ; Choi, Yunhee ; Blumenthal, Roger S. ; Rivera, Juan J. ; Nasir, Khurram ; Kim, Yong Jin ; Sohn, Dae Won ; Oh, Byung Hee ; Park, Young Bae ; Chang, Hyuk-Jae. / Coronary atherosclerosis detected by coronary CT angiography in asymptomatic subjects with early chronic kidney disease. In: Atherosclerosis. 2010 ; Vol. 208, No. 2. pp. 406-411.
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abstract = "Objectives: The purpose of this study is to assess the independent association between early CKD (stages 1-3a) with coronary atherosclerosis and the feasibility of risk stratification of coronary atherosclerosis according to The Kidney Disease Outcomes Quality Initiative (K/DOQI) guidelines using non-invasive coronary angiography. Methods: We consecutively enrolled 4297 asymptomatic subjects who underwent coronary CT angiography as part of a general health evaluation and had estimated glomerular filtration rates (eGFR) over 45 ml/min/1.73 m2. Subjects were categorized from no CKD to stage 3a CKD, and multiple regression analyses for coronary atherosclerosis were performed. Results: Early CKD was an independent risk factor for coronary artery disease (CAD) and obstructive CAD. However, neither the risk of CAD nor CACS >100 increased as stage of CKD advanced. The reason for unsuccessful stratification of coronary atherosclerosis risk was that the presence of proteinuria, which was used to define stages 1 and 2 CKD, was an independent risk factor for coronary atherosclerosis, but eGFR of 45-89 ml/min/1.73 m2 was not associated with coronary atherosclerosis. Conclusions: Early CKD was an independent risk factor for coronary atherosclerosis, and the risk stratification for coronary atherosclerosis should be based on the presence of proteinuria rather than decreased eGFR within early CKD.",
author = "Iksung Cho and Min, {Hee Suk} and Chun, {Eun Ju} and Park, {Sue K.} and Yunhee Choi and Blumenthal, {Roger S.} and Rivera, {Juan J.} and Khurram Nasir and Kim, {Yong Jin} and Sohn, {Dae Won} and Oh, {Byung Hee} and Park, {Young Bae} and Hyuk-Jae Chang",
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Cho, I, Min, HS, Chun, EJ, Park, SK, Choi, Y, Blumenthal, RS, Rivera, JJ, Nasir, K, Kim, YJ, Sohn, DW, Oh, BH, Park, YB & Chang, H-J 2010, 'Coronary atherosclerosis detected by coronary CT angiography in asymptomatic subjects with early chronic kidney disease', Atherosclerosis, vol. 208, no. 2, pp. 406-411. https://doi.org/10.1016/j.atherosclerosis.2009.08.040

Coronary atherosclerosis detected by coronary CT angiography in asymptomatic subjects with early chronic kidney disease. / Cho, Iksung; Min, Hee Suk; Chun, Eun Ju; Park, Sue K.; Choi, Yunhee; Blumenthal, Roger S.; Rivera, Juan J.; Nasir, Khurram; Kim, Yong Jin; Sohn, Dae Won; Oh, Byung Hee; Park, Young Bae; Chang, Hyuk-Jae.

In: Atherosclerosis, Vol. 208, No. 2, 01.02.2010, p. 406-411.

Research output: Contribution to journalArticle

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T1 - Coronary atherosclerosis detected by coronary CT angiography in asymptomatic subjects with early chronic kidney disease

AU - Cho, Iksung

AU - Min, Hee Suk

AU - Chun, Eun Ju

AU - Park, Sue K.

AU - Choi, Yunhee

AU - Blumenthal, Roger S.

AU - Rivera, Juan J.

AU - Nasir, Khurram

AU - Kim, Yong Jin

AU - Sohn, Dae Won

AU - Oh, Byung Hee

AU - Park, Young Bae

AU - Chang, Hyuk-Jae

PY - 2010/2/1

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N2 - Objectives: The purpose of this study is to assess the independent association between early CKD (stages 1-3a) with coronary atherosclerosis and the feasibility of risk stratification of coronary atherosclerosis according to The Kidney Disease Outcomes Quality Initiative (K/DOQI) guidelines using non-invasive coronary angiography. Methods: We consecutively enrolled 4297 asymptomatic subjects who underwent coronary CT angiography as part of a general health evaluation and had estimated glomerular filtration rates (eGFR) over 45 ml/min/1.73 m2. Subjects were categorized from no CKD to stage 3a CKD, and multiple regression analyses for coronary atherosclerosis were performed. Results: Early CKD was an independent risk factor for coronary artery disease (CAD) and obstructive CAD. However, neither the risk of CAD nor CACS >100 increased as stage of CKD advanced. The reason for unsuccessful stratification of coronary atherosclerosis risk was that the presence of proteinuria, which was used to define stages 1 and 2 CKD, was an independent risk factor for coronary atherosclerosis, but eGFR of 45-89 ml/min/1.73 m2 was not associated with coronary atherosclerosis. Conclusions: Early CKD was an independent risk factor for coronary atherosclerosis, and the risk stratification for coronary atherosclerosis should be based on the presence of proteinuria rather than decreased eGFR within early CKD.

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