Correlation between anatomy and electrical activation in canine pulmonary veins

Akira Hamabe, Yuji Okuyama, Yasushi Miyauchi, Shengmei Zhou, Hui Nam Pak, Hrayr S. Karagueuzian, Michael C. Fishbein, Peng Sheng Chen

Research output: Contribution to journalArticle

84 Citations (Scopus)

Abstract

Background - The roles of complex muscle sleeve geometry and fiber orientation in the pulmonary veins (PVs) in wave-front propagation are poorly understood. Methods and Results - We mapped the left superior PV (LSPV, n=7) and left inferior PV (LIPV, n=4) of dogs with 420 bipolar electrodes (1-mm resolution) and performed detailed histological examination. In the anterior LSPV-left atrial (LA) junction, myocardial muscle fibers were oriented perpendicular to PV blood flow. A wedge filled with connective tissues led to a complete muscle separation or an abrupt increase in muscle thickness between the PV and LA (0.42±0.12 versus 2.0±0.31 mm, P<0.01). Distal LSPV pacing resulted in conduction block at the anterior PV-LA junction, with double potentials. In contrast, the posterior LSPV-LA junction showed gradual muscle thickening and a fiber orientation parallel to the blood flow. The maximum PV muscle thickness in the anterior PV-LA junction is thinner than that in the posterior junction (0.83±0.15 versus 1.3±0.38 mm, P<0.01). Distal LIPV pacing showed multiple PV-LA breakthroughs, with segmental conduction block in the anterior PV-LA junction. The conduction block corresponded to segmental PV-LA muscle disconnection. Complex fiber orientations in the PV muscle sleeves away from the PV-LA junction were responsible for intra-PV conduction delay or block during rapid PV pacing. Conclusions - We conclude that segmental muscle disconnection and differential muscle narrowing at PV-LA junctions and complex fiber orientations within the PV provide robust anatomical bases for conduction disturbance at the PV-LA junction and complex intra-PV conduction patterns.

Original languageEnglish
Pages (from-to)1550-1555
Number of pages6
JournalCirculation
Volume107
Issue number11
DOIs
Publication statusPublished - 2003 Mar 25

Fingerprint

Pulmonary Veins
Canidae
Anatomy
Muscles

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Cite this

Hamabe, A., Okuyama, Y., Miyauchi, Y., Zhou, S., Pak, H. N., Karagueuzian, H. S., ... Chen, P. S. (2003). Correlation between anatomy and electrical activation in canine pulmonary veins. Circulation, 107(11), 1550-1555. https://doi.org/10.1161/01.CIR.0000056765.97013.5E
Hamabe, Akira ; Okuyama, Yuji ; Miyauchi, Yasushi ; Zhou, Shengmei ; Pak, Hui Nam ; Karagueuzian, Hrayr S. ; Fishbein, Michael C. ; Chen, Peng Sheng. / Correlation between anatomy and electrical activation in canine pulmonary veins. In: Circulation. 2003 ; Vol. 107, No. 11. pp. 1550-1555.
@article{00812961a3994304b7707716cd1323d9,
title = "Correlation between anatomy and electrical activation in canine pulmonary veins",
abstract = "Background - The roles of complex muscle sleeve geometry and fiber orientation in the pulmonary veins (PVs) in wave-front propagation are poorly understood. Methods and Results - We mapped the left superior PV (LSPV, n=7) and left inferior PV (LIPV, n=4) of dogs with 420 bipolar electrodes (1-mm resolution) and performed detailed histological examination. In the anterior LSPV-left atrial (LA) junction, myocardial muscle fibers were oriented perpendicular to PV blood flow. A wedge filled with connective tissues led to a complete muscle separation or an abrupt increase in muscle thickness between the PV and LA (0.42±0.12 versus 2.0±0.31 mm, P<0.01). Distal LSPV pacing resulted in conduction block at the anterior PV-LA junction, with double potentials. In contrast, the posterior LSPV-LA junction showed gradual muscle thickening and a fiber orientation parallel to the blood flow. The maximum PV muscle thickness in the anterior PV-LA junction is thinner than that in the posterior junction (0.83±0.15 versus 1.3±0.38 mm, P<0.01). Distal LIPV pacing showed multiple PV-LA breakthroughs, with segmental conduction block in the anterior PV-LA junction. The conduction block corresponded to segmental PV-LA muscle disconnection. Complex fiber orientations in the PV muscle sleeves away from the PV-LA junction were responsible for intra-PV conduction delay or block during rapid PV pacing. Conclusions - We conclude that segmental muscle disconnection and differential muscle narrowing at PV-LA junctions and complex fiber orientations within the PV provide robust anatomical bases for conduction disturbance at the PV-LA junction and complex intra-PV conduction patterns.",
author = "Akira Hamabe and Yuji Okuyama and Yasushi Miyauchi and Shengmei Zhou and Pak, {Hui Nam} and Karagueuzian, {Hrayr S.} and Fishbein, {Michael C.} and Chen, {Peng Sheng}",
year = "2003",
month = "3",
day = "25",
doi = "10.1161/01.CIR.0000056765.97013.5E",
language = "English",
volume = "107",
pages = "1550--1555",
journal = "Circulation",
issn = "0009-7322",
publisher = "Lippincott Williams and Wilkins",
number = "11",

}

Hamabe, A, Okuyama, Y, Miyauchi, Y, Zhou, S, Pak, HN, Karagueuzian, HS, Fishbein, MC & Chen, PS 2003, 'Correlation between anatomy and electrical activation in canine pulmonary veins', Circulation, vol. 107, no. 11, pp. 1550-1555. https://doi.org/10.1161/01.CIR.0000056765.97013.5E

Correlation between anatomy and electrical activation in canine pulmonary veins. / Hamabe, Akira; Okuyama, Yuji; Miyauchi, Yasushi; Zhou, Shengmei; Pak, Hui Nam; Karagueuzian, Hrayr S.; Fishbein, Michael C.; Chen, Peng Sheng.

In: Circulation, Vol. 107, No. 11, 25.03.2003, p. 1550-1555.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Correlation between anatomy and electrical activation in canine pulmonary veins

AU - Hamabe, Akira

AU - Okuyama, Yuji

AU - Miyauchi, Yasushi

AU - Zhou, Shengmei

AU - Pak, Hui Nam

AU - Karagueuzian, Hrayr S.

AU - Fishbein, Michael C.

AU - Chen, Peng Sheng

PY - 2003/3/25

Y1 - 2003/3/25

N2 - Background - The roles of complex muscle sleeve geometry and fiber orientation in the pulmonary veins (PVs) in wave-front propagation are poorly understood. Methods and Results - We mapped the left superior PV (LSPV, n=7) and left inferior PV (LIPV, n=4) of dogs with 420 bipolar electrodes (1-mm resolution) and performed detailed histological examination. In the anterior LSPV-left atrial (LA) junction, myocardial muscle fibers were oriented perpendicular to PV blood flow. A wedge filled with connective tissues led to a complete muscle separation or an abrupt increase in muscle thickness between the PV and LA (0.42±0.12 versus 2.0±0.31 mm, P<0.01). Distal LSPV pacing resulted in conduction block at the anterior PV-LA junction, with double potentials. In contrast, the posterior LSPV-LA junction showed gradual muscle thickening and a fiber orientation parallel to the blood flow. The maximum PV muscle thickness in the anterior PV-LA junction is thinner than that in the posterior junction (0.83±0.15 versus 1.3±0.38 mm, P<0.01). Distal LIPV pacing showed multiple PV-LA breakthroughs, with segmental conduction block in the anterior PV-LA junction. The conduction block corresponded to segmental PV-LA muscle disconnection. Complex fiber orientations in the PV muscle sleeves away from the PV-LA junction were responsible for intra-PV conduction delay or block during rapid PV pacing. Conclusions - We conclude that segmental muscle disconnection and differential muscle narrowing at PV-LA junctions and complex fiber orientations within the PV provide robust anatomical bases for conduction disturbance at the PV-LA junction and complex intra-PV conduction patterns.

AB - Background - The roles of complex muscle sleeve geometry and fiber orientation in the pulmonary veins (PVs) in wave-front propagation are poorly understood. Methods and Results - We mapped the left superior PV (LSPV, n=7) and left inferior PV (LIPV, n=4) of dogs with 420 bipolar electrodes (1-mm resolution) and performed detailed histological examination. In the anterior LSPV-left atrial (LA) junction, myocardial muscle fibers were oriented perpendicular to PV blood flow. A wedge filled with connective tissues led to a complete muscle separation or an abrupt increase in muscle thickness between the PV and LA (0.42±0.12 versus 2.0±0.31 mm, P<0.01). Distal LSPV pacing resulted in conduction block at the anterior PV-LA junction, with double potentials. In contrast, the posterior LSPV-LA junction showed gradual muscle thickening and a fiber orientation parallel to the blood flow. The maximum PV muscle thickness in the anterior PV-LA junction is thinner than that in the posterior junction (0.83±0.15 versus 1.3±0.38 mm, P<0.01). Distal LIPV pacing showed multiple PV-LA breakthroughs, with segmental conduction block in the anterior PV-LA junction. The conduction block corresponded to segmental PV-LA muscle disconnection. Complex fiber orientations in the PV muscle sleeves away from the PV-LA junction were responsible for intra-PV conduction delay or block during rapid PV pacing. Conclusions - We conclude that segmental muscle disconnection and differential muscle narrowing at PV-LA junctions and complex fiber orientations within the PV provide robust anatomical bases for conduction disturbance at the PV-LA junction and complex intra-PV conduction patterns.

UR - http://www.scopus.com/inward/record.url?scp=0037465736&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037465736&partnerID=8YFLogxK

U2 - 10.1161/01.CIR.0000056765.97013.5E

DO - 10.1161/01.CIR.0000056765.97013.5E

M3 - Article

C2 - 12654615

AN - SCOPUS:0037465736

VL - 107

SP - 1550

EP - 1555

JO - Circulation

JF - Circulation

SN - 0009-7322

IS - 11

ER -

Hamabe A, Okuyama Y, Miyauchi Y, Zhou S, Pak HN, Karagueuzian HS et al. Correlation between anatomy and electrical activation in canine pulmonary veins. Circulation. 2003 Mar 25;107(11):1550-1555. https://doi.org/10.1161/01.CIR.0000056765.97013.5E