Correlation between cardiac 123I-MIBG and odor identification in patients with Parkinson's disease and multiple system atrophy

Phil Hyu Lee, Seung Hyeon Yeo, Hyun Joon Kim, Hyo Young Youm

Research output: Contribution to journalArticlepeer-review

65 Citations (Scopus)

Abstract

We investigated an association between olfaction and cardiac 123I-metaiodobenzylguanidine (MIBG) uptake in patients with Parkinson's disease (PD) and multiple system atrophy (MSA). There was a significant positive correlation between cardiac MIBG uptake and the Cross-Cultural Smell Identification (CCSI) score in patients with PD (r = 0.56; P = 0.003) independent of the disease duration or clinical rating of motor status. However, patients with MSA did not show a significant correlation between cardiac MIBG uptake and the CCSI score. Our findings suggest that the functional losses of the olfactory and cardiac sympathetic systems are closely coupled in PD.

Original languageEnglish
Pages (from-to)1975-1977
Number of pages3
JournalMovement Disorders
Volume21
Issue number11
DOIs
Publication statusPublished - 2006 Nov

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

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