Correlation between electrical conductivity and apparent diffusion coefficient in breast cancer

effect of necrosis on magnetic resonance imaging

Soo Yeon Kim, Jaewook Shin, Donghyun Kim, Eunkyung Kim, Hee Jung Moon, Jung Hyun Yoon, Jai Kyung You, minjung Kim

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Objectives: To investigate the correlation between conductivity and ADC in invasive ductal carcinoma according to the presence of necrosis on MRI. Methods: Eighty-one women with invasive ductal carcinoma ≥1 cm on T2-weighted fast spin echo sequence of preoperative MRI were included. Phase-based MR electric properties tomography was used to reconstruct conductivity. Mean ADC was measured. Necrosis was defined as an area with very high T2 signal intensity. The relationship between conductivity and ADC was examined using Spearman’s correlation coefficient (r). Multiple linear regression analysis was performed to identify factors associated with conductivity or ADC. Results: In the total group, conductivity showed negative correlation with ADC (r = –0.357, p = 0.001). This correlation was maintained in the subgroup without necrosis (n = 53, r = –0.455, p = 0.001), but not in the subgroup with necrosis (n = 28, r = –0.080, p = 0.687). The correlation between the two parameters was different according to necrosis (r = -0.455 vs -0.080, p = 0.047). HER2 enriched subtype was independently associated with conductivity (p = 0.029). Necrosis on MRI was independently associated with ADC (p = 0.027). Conclusions: Conductivity shows negative correlation with ADC that is abolished by the presence of necrosis on MRI. Key Points: • Electric conductivity showed negative correlation with ADC • However, the correlation was abolished by the presence of necrosis on MRI • HER2-enriched subtype was independently associated with conductivity • Necrosis on MRI was independently associated with ADC.

Original languageEnglish
Pages (from-to)3204-3214
Number of pages11
JournalEuropean Radiology
Volume28
Issue number8
DOIs
Publication statusPublished - 2018 Aug 1

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Electric Conductivity
Necrosis
Magnetic Resonance Imaging
Breast Neoplasms
Ductal Carcinoma
Linear Models
Tomography
Regression Analysis

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

Cite this

@article{a4e2f9fb1f084a05a395c86c830c7bdc,
title = "Correlation between electrical conductivity and apparent diffusion coefficient in breast cancer: effect of necrosis on magnetic resonance imaging",
abstract = "Objectives: To investigate the correlation between conductivity and ADC in invasive ductal carcinoma according to the presence of necrosis on MRI. Methods: Eighty-one women with invasive ductal carcinoma ≥1 cm on T2-weighted fast spin echo sequence of preoperative MRI were included. Phase-based MR electric properties tomography was used to reconstruct conductivity. Mean ADC was measured. Necrosis was defined as an area with very high T2 signal intensity. The relationship between conductivity and ADC was examined using Spearman’s correlation coefficient (r). Multiple linear regression analysis was performed to identify factors associated with conductivity or ADC. Results: In the total group, conductivity showed negative correlation with ADC (r = –0.357, p = 0.001). This correlation was maintained in the subgroup without necrosis (n = 53, r = –0.455, p = 0.001), but not in the subgroup with necrosis (n = 28, r = –0.080, p = 0.687). The correlation between the two parameters was different according to necrosis (r = -0.455 vs -0.080, p = 0.047). HER2 enriched subtype was independently associated with conductivity (p = 0.029). Necrosis on MRI was independently associated with ADC (p = 0.027). Conclusions: Conductivity shows negative correlation with ADC that is abolished by the presence of necrosis on MRI. Key Points: • Electric conductivity showed negative correlation with ADC • However, the correlation was abolished by the presence of necrosis on MRI • HER2-enriched subtype was independently associated with conductivity • Necrosis on MRI was independently associated with ADC.",
author = "Kim, {Soo Yeon} and Jaewook Shin and Donghyun Kim and Eunkyung Kim and Moon, {Hee Jung} and Yoon, {Jung Hyun} and You, {Jai Kyung} and minjung Kim",
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Correlation between electrical conductivity and apparent diffusion coefficient in breast cancer : effect of necrosis on magnetic resonance imaging. / Kim, Soo Yeon; Shin, Jaewook; Kim, Donghyun; Kim, Eunkyung; Moon, Hee Jung; Yoon, Jung Hyun; You, Jai Kyung; Kim, minjung.

In: European Radiology, Vol. 28, No. 8, 01.08.2018, p. 3204-3214.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Correlation between electrical conductivity and apparent diffusion coefficient in breast cancer

T2 - effect of necrosis on magnetic resonance imaging

AU - Kim, Soo Yeon

AU - Shin, Jaewook

AU - Kim, Donghyun

AU - Kim, Eunkyung

AU - Moon, Hee Jung

AU - Yoon, Jung Hyun

AU - You, Jai Kyung

AU - Kim, minjung

PY - 2018/8/1

Y1 - 2018/8/1

N2 - Objectives: To investigate the correlation between conductivity and ADC in invasive ductal carcinoma according to the presence of necrosis on MRI. Methods: Eighty-one women with invasive ductal carcinoma ≥1 cm on T2-weighted fast spin echo sequence of preoperative MRI were included. Phase-based MR electric properties tomography was used to reconstruct conductivity. Mean ADC was measured. Necrosis was defined as an area with very high T2 signal intensity. The relationship between conductivity and ADC was examined using Spearman’s correlation coefficient (r). Multiple linear regression analysis was performed to identify factors associated with conductivity or ADC. Results: In the total group, conductivity showed negative correlation with ADC (r = –0.357, p = 0.001). This correlation was maintained in the subgroup without necrosis (n = 53, r = –0.455, p = 0.001), but not in the subgroup with necrosis (n = 28, r = –0.080, p = 0.687). The correlation between the two parameters was different according to necrosis (r = -0.455 vs -0.080, p = 0.047). HER2 enriched subtype was independently associated with conductivity (p = 0.029). Necrosis on MRI was independently associated with ADC (p = 0.027). Conclusions: Conductivity shows negative correlation with ADC that is abolished by the presence of necrosis on MRI. Key Points: • Electric conductivity showed negative correlation with ADC • However, the correlation was abolished by the presence of necrosis on MRI • HER2-enriched subtype was independently associated with conductivity • Necrosis on MRI was independently associated with ADC.

AB - Objectives: To investigate the correlation between conductivity and ADC in invasive ductal carcinoma according to the presence of necrosis on MRI. Methods: Eighty-one women with invasive ductal carcinoma ≥1 cm on T2-weighted fast spin echo sequence of preoperative MRI were included. Phase-based MR electric properties tomography was used to reconstruct conductivity. Mean ADC was measured. Necrosis was defined as an area with very high T2 signal intensity. The relationship between conductivity and ADC was examined using Spearman’s correlation coefficient (r). Multiple linear regression analysis was performed to identify factors associated with conductivity or ADC. Results: In the total group, conductivity showed negative correlation with ADC (r = –0.357, p = 0.001). This correlation was maintained in the subgroup without necrosis (n = 53, r = –0.455, p = 0.001), but not in the subgroup with necrosis (n = 28, r = –0.080, p = 0.687). The correlation between the two parameters was different according to necrosis (r = -0.455 vs -0.080, p = 0.047). HER2 enriched subtype was independently associated with conductivity (p = 0.029). Necrosis on MRI was independently associated with ADC (p = 0.027). Conclusions: Conductivity shows negative correlation with ADC that is abolished by the presence of necrosis on MRI. Key Points: • Electric conductivity showed negative correlation with ADC • However, the correlation was abolished by the presence of necrosis on MRI • HER2-enriched subtype was independently associated with conductivity • Necrosis on MRI was independently associated with ADC.

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U2 - 10.1007/s00330-017-5291-0

DO - 10.1007/s00330-017-5291-0

M3 - Article

VL - 28

SP - 3204

EP - 3214

JO - European Radiology

JF - European Radiology

SN - 0938-7994

IS - 8

ER -