Correlation between iodine intake and thyroid function in subjects with normal thyroid function

Sena Hwang, Eun Young Lee, Woo Kyung Lee, Dong Yeob Shin, Eunjig Lee

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Excessive iodine intake is known to induce hypothyroidism in people who have underlying thyroid disorders. However, few studies have been performed on subjects with normal thyroid function without a history of autoimmune thyroid disease. We hypothesized that high iodine intake may cause a subtle change in thyroid function even in subjects with normal thyroid function. We analyzed 337 subjects (64 men and 273 women; mean age, 49 years) who showed normal levels of thyroid peroxidase antibodies (TPO-Ab) and thyroglobulin antibodies (Tg-Ab) by measuring the urinary iodine excretion, free T4 (FT4), and thyroid-stimulating hormone (TSH). The results showed urinary iodine excretion had negative correlation with FT4 (γ = -0.11, p = 0.043) and showed a positive trend with TSH (γ = 0.10, p = 0.068). We found that 61.7% of subjects had circulating TPO-Ab within normal reference range. In all subjects, TPO-Ab levels were negatively correlated with FT4 (γ = -0.17, p = 0.002) and positively with TSH (γ = 0.13, p = 0.021). In conclusion, high iodine intake can negatively affect thyroid hormone levels in subjects with normal thyroid function. Population-based study will be helpful for further clarification.

Original languageEnglish
Pages (from-to)1393-1397
Number of pages5
JournalBiological Trace Element Research
Volume143
Issue number3
DOIs
Publication statusPublished - 2011 Dec 1

Fingerprint

Iodine
Thyroid Gland
Iodide Peroxidase
Thyrotropin
Antibodies
Reference Values
Thyroglobulin
Thyroid Diseases
Hypothyroidism
Thyroxine
Thyroid Hormones
Autoimmune Diseases
Population

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Clinical Biochemistry
  • Inorganic Chemistry
  • Biochemistry, medical

Cite this

Hwang, Sena ; Lee, Eun Young ; Lee, Woo Kyung ; Shin, Dong Yeob ; Lee, Eunjig. / Correlation between iodine intake and thyroid function in subjects with normal thyroid function. In: Biological Trace Element Research. 2011 ; Vol. 143, No. 3. pp. 1393-1397.
@article{644f245970c24c26aa1651c241015320,
title = "Correlation between iodine intake and thyroid function in subjects with normal thyroid function",
abstract = "Excessive iodine intake is known to induce hypothyroidism in people who have underlying thyroid disorders. However, few studies have been performed on subjects with normal thyroid function without a history of autoimmune thyroid disease. We hypothesized that high iodine intake may cause a subtle change in thyroid function even in subjects with normal thyroid function. We analyzed 337 subjects (64 men and 273 women; mean age, 49 years) who showed normal levels of thyroid peroxidase antibodies (TPO-Ab) and thyroglobulin antibodies (Tg-Ab) by measuring the urinary iodine excretion, free T4 (FT4), and thyroid-stimulating hormone (TSH). The results showed urinary iodine excretion had negative correlation with FT4 (γ = -0.11, p = 0.043) and showed a positive trend with TSH (γ = 0.10, p = 0.068). We found that 61.7{\%} of subjects had circulating TPO-Ab within normal reference range. In all subjects, TPO-Ab levels were negatively correlated with FT4 (γ = -0.17, p = 0.002) and positively with TSH (γ = 0.13, p = 0.021). In conclusion, high iodine intake can negatively affect thyroid hormone levels in subjects with normal thyroid function. Population-based study will be helpful for further clarification.",
author = "Sena Hwang and Lee, {Eun Young} and Lee, {Woo Kyung} and Shin, {Dong Yeob} and Eunjig Lee",
year = "2011",
month = "12",
day = "1",
doi = "10.1007/s12011-011-8997-x",
language = "English",
volume = "143",
pages = "1393--1397",
journal = "Biological Trace Element Research",
issn = "0163-4984",
publisher = "Humana Press",
number = "3",

}

Correlation between iodine intake and thyroid function in subjects with normal thyroid function. / Hwang, Sena; Lee, Eun Young; Lee, Woo Kyung; Shin, Dong Yeob; Lee, Eunjig.

In: Biological Trace Element Research, Vol. 143, No. 3, 01.12.2011, p. 1393-1397.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Correlation between iodine intake and thyroid function in subjects with normal thyroid function

AU - Hwang, Sena

AU - Lee, Eun Young

AU - Lee, Woo Kyung

AU - Shin, Dong Yeob

AU - Lee, Eunjig

PY - 2011/12/1

Y1 - 2011/12/1

N2 - Excessive iodine intake is known to induce hypothyroidism in people who have underlying thyroid disorders. However, few studies have been performed on subjects with normal thyroid function without a history of autoimmune thyroid disease. We hypothesized that high iodine intake may cause a subtle change in thyroid function even in subjects with normal thyroid function. We analyzed 337 subjects (64 men and 273 women; mean age, 49 years) who showed normal levels of thyroid peroxidase antibodies (TPO-Ab) and thyroglobulin antibodies (Tg-Ab) by measuring the urinary iodine excretion, free T4 (FT4), and thyroid-stimulating hormone (TSH). The results showed urinary iodine excretion had negative correlation with FT4 (γ = -0.11, p = 0.043) and showed a positive trend with TSH (γ = 0.10, p = 0.068). We found that 61.7% of subjects had circulating TPO-Ab within normal reference range. In all subjects, TPO-Ab levels were negatively correlated with FT4 (γ = -0.17, p = 0.002) and positively with TSH (γ = 0.13, p = 0.021). In conclusion, high iodine intake can negatively affect thyroid hormone levels in subjects with normal thyroid function. Population-based study will be helpful for further clarification.

AB - Excessive iodine intake is known to induce hypothyroidism in people who have underlying thyroid disorders. However, few studies have been performed on subjects with normal thyroid function without a history of autoimmune thyroid disease. We hypothesized that high iodine intake may cause a subtle change in thyroid function even in subjects with normal thyroid function. We analyzed 337 subjects (64 men and 273 women; mean age, 49 years) who showed normal levels of thyroid peroxidase antibodies (TPO-Ab) and thyroglobulin antibodies (Tg-Ab) by measuring the urinary iodine excretion, free T4 (FT4), and thyroid-stimulating hormone (TSH). The results showed urinary iodine excretion had negative correlation with FT4 (γ = -0.11, p = 0.043) and showed a positive trend with TSH (γ = 0.10, p = 0.068). We found that 61.7% of subjects had circulating TPO-Ab within normal reference range. In all subjects, TPO-Ab levels were negatively correlated with FT4 (γ = -0.17, p = 0.002) and positively with TSH (γ = 0.13, p = 0.021). In conclusion, high iodine intake can negatively affect thyroid hormone levels in subjects with normal thyroid function. Population-based study will be helpful for further clarification.

UR - http://www.scopus.com/inward/record.url?scp=82455212138&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=82455212138&partnerID=8YFLogxK

U2 - 10.1007/s12011-011-8997-x

DO - 10.1007/s12011-011-8997-x

M3 - Article

VL - 143

SP - 1393

EP - 1397

JO - Biological Trace Element Research

JF - Biological Trace Element Research

SN - 0163-4984

IS - 3

ER -