Correlation between midthigh low-density muscle and insulin resistance in obese nondiabetic patients in Korea

Dolmi Kim, Suyoun Nam, Chulwoo Ahn, Kyungwook Kim, Soojee Yoon, Junuh Kim, Bongsoo Cha, Sungkil Lim, Kyungrae Kim, Hyunchul Lee, Kapbum Huh

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

OBJECTIVE - We investigated the link between lipid-rich skeletal muscle, namely low-density muscle, and insulin resistance in Korea. RESEARCH DESIGN AND METHODS - Abdominal adipose tissue areas and midthigh skeletal muscle areas of 75 obese nondiabetic subjects (23 men, 52 women; mean age ± SD, 41.9 ± 14.1 years) were measured by computed tomography (CT). The midthigh skeletal muscle areas were subdivided into low-density muscle (0 to +30 Hounsfield units) and normal-density muscle (+31 to +100 Hounsfield units). The homeostasis model assessment (HOMA) score was calculated to assess whole-body insulin sensitivity. RESULTS - The abdominal visceral fat area and the midthigh low-density muscle area were found to be well correlated with the HOMA score (r = 0.471, P < 0.01 and r = 0.513, P < 0.01, respectively). The correlation between low-density muscle area and insulin resistance persisted after adjusting for BMI or total body fat mass (r = 0.451, P < 0.01 and r = 0.522, P < 0.01, respectively) and even after adjusting for abdominal visceral fat area (r = 0.399, P < 0.01). CONCLUSIONS - The midthigh low-density muscle area seems to be a reliable determinant of insulin resistance in Korean obese nondiabetic patients.

Original languageEnglish
Pages (from-to)1825-1830
Number of pages6
JournalDiabetes Care
Volume26
Issue number6
DOIs
Publication statusPublished - 2003 Jun 1

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Korea
Insulin Resistance
Muscles
Skeletal Muscle
Intra-Abdominal Fat
Homeostasis
Abdominal Fat
Adipose Tissue
Research Design
Tomography
Lipids

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Advanced and Specialised Nursing

Cite this

Kim, Dolmi ; Nam, Suyoun ; Ahn, Chulwoo ; Kim, Kyungwook ; Yoon, Soojee ; Kim, Junuh ; Cha, Bongsoo ; Lim, Sungkil ; Kim, Kyungrae ; Lee, Hyunchul ; Huh, Kapbum. / Correlation between midthigh low-density muscle and insulin resistance in obese nondiabetic patients in Korea. In: Diabetes Care. 2003 ; Vol. 26, No. 6. pp. 1825-1830.
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Kim, D, Nam, S, Ahn, C, Kim, K, Yoon, S, Kim, J, Cha, B, Lim, S, Kim, K, Lee, H & Huh, K 2003, 'Correlation between midthigh low-density muscle and insulin resistance in obese nondiabetic patients in Korea', Diabetes Care, vol. 26, no. 6, pp. 1825-1830. https://doi.org/10.2337/diacare.26.6.1825

Correlation between midthigh low-density muscle and insulin resistance in obese nondiabetic patients in Korea. / Kim, Dolmi; Nam, Suyoun; Ahn, Chulwoo; Kim, Kyungwook; Yoon, Soojee; Kim, Junuh; Cha, Bongsoo; Lim, Sungkil; Kim, Kyungrae; Lee, Hyunchul; Huh, Kapbum.

In: Diabetes Care, Vol. 26, No. 6, 01.06.2003, p. 1825-1830.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Correlation between midthigh low-density muscle and insulin resistance in obese nondiabetic patients in Korea

AU - Kim, Dolmi

AU - Nam, Suyoun

AU - Ahn, Chulwoo

AU - Kim, Kyungwook

AU - Yoon, Soojee

AU - Kim, Junuh

AU - Cha, Bongsoo

AU - Lim, Sungkil

AU - Kim, Kyungrae

AU - Lee, Hyunchul

AU - Huh, Kapbum

PY - 2003/6/1

Y1 - 2003/6/1

N2 - OBJECTIVE - We investigated the link between lipid-rich skeletal muscle, namely low-density muscle, and insulin resistance in Korea. RESEARCH DESIGN AND METHODS - Abdominal adipose tissue areas and midthigh skeletal muscle areas of 75 obese nondiabetic subjects (23 men, 52 women; mean age ± SD, 41.9 ± 14.1 years) were measured by computed tomography (CT). The midthigh skeletal muscle areas were subdivided into low-density muscle (0 to +30 Hounsfield units) and normal-density muscle (+31 to +100 Hounsfield units). The homeostasis model assessment (HOMA) score was calculated to assess whole-body insulin sensitivity. RESULTS - The abdominal visceral fat area and the midthigh low-density muscle area were found to be well correlated with the HOMA score (r = 0.471, P < 0.01 and r = 0.513, P < 0.01, respectively). The correlation between low-density muscle area and insulin resistance persisted after adjusting for BMI or total body fat mass (r = 0.451, P < 0.01 and r = 0.522, P < 0.01, respectively) and even after adjusting for abdominal visceral fat area (r = 0.399, P < 0.01). CONCLUSIONS - The midthigh low-density muscle area seems to be a reliable determinant of insulin resistance in Korean obese nondiabetic patients.

AB - OBJECTIVE - We investigated the link between lipid-rich skeletal muscle, namely low-density muscle, and insulin resistance in Korea. RESEARCH DESIGN AND METHODS - Abdominal adipose tissue areas and midthigh skeletal muscle areas of 75 obese nondiabetic subjects (23 men, 52 women; mean age ± SD, 41.9 ± 14.1 years) were measured by computed tomography (CT). The midthigh skeletal muscle areas were subdivided into low-density muscle (0 to +30 Hounsfield units) and normal-density muscle (+31 to +100 Hounsfield units). The homeostasis model assessment (HOMA) score was calculated to assess whole-body insulin sensitivity. RESULTS - The abdominal visceral fat area and the midthigh low-density muscle area were found to be well correlated with the HOMA score (r = 0.471, P < 0.01 and r = 0.513, P < 0.01, respectively). The correlation between low-density muscle area and insulin resistance persisted after adjusting for BMI or total body fat mass (r = 0.451, P < 0.01 and r = 0.522, P < 0.01, respectively) and even after adjusting for abdominal visceral fat area (r = 0.399, P < 0.01). CONCLUSIONS - The midthigh low-density muscle area seems to be a reliable determinant of insulin resistance in Korean obese nondiabetic patients.

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