Correlation between proliferating index and prognostic factors in papillary cystic tumors of the pancreas.

N. H. Cho, J. H. Go, S. H. Jung, W. H. Jung, K. K. Lee

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Fifteen cases of papillary cystic tumor of the pancreas (PCTP) were studied (14 female patients, one male patient; mean age: 23.5 years). Most tumors developed in the head of the pancreas as a well circumscribed large mass. The tumor had a mean diameter of 6.7 cm(range; 2 to 15 cm). Histopathologically abundant delicate papillary fragments, monomorphic tumor cells and degenerative changes of the solid area of the tumor were characteristic. All but two cases had completely circumscribed capsules. Two cases had duodenal invasion; one of all cases had cul de sac metastasis. Compared with 12 non-aggressive tumors, the aggressive cases had larger tumor size (more than 9 cm) with a thicker capsule (more than 2 mm). In studies to investigate the prognostic index using nucleolar organizing region (NOR), proliferating cell nuclear antigen (PCNA) and flow cytometry as well as nuclear grade and mitotic index, we could not find the useful parameter to detect the malignant potential of PCTP. In the flow cytometric analysis of cellular DNA contents, two invasive cases and the only one case of the male patient among the non-aggressive group were aneuploid. In conclusion, although it is hard to predict the prognosis by microscopic findings only, those with a thick capsule and aneuploidy tend to be related to malignant potential.

Original languageEnglish
Pages (from-to)342-351
Number of pages10
JournalJournal of Korean medical science
Volume10
Issue number5
DOIs
Publication statusPublished - 1995 Oct

Fingerprint

Pancreas
Neoplasms
Capsules
Aneuploidy
Mitotic Index
Proliferating Cell Nuclear Antigen
Flow Cytometry
Neoplasm Metastasis
DNA

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

@article{c71873cf3ad84a3cb900ac1c4f2e9c3d,
title = "Correlation between proliferating index and prognostic factors in papillary cystic tumors of the pancreas.",
abstract = "Fifteen cases of papillary cystic tumor of the pancreas (PCTP) were studied (14 female patients, one male patient; mean age: 23.5 years). Most tumors developed in the head of the pancreas as a well circumscribed large mass. The tumor had a mean diameter of 6.7 cm(range; 2 to 15 cm). Histopathologically abundant delicate papillary fragments, monomorphic tumor cells and degenerative changes of the solid area of the tumor were characteristic. All but two cases had completely circumscribed capsules. Two cases had duodenal invasion; one of all cases had cul de sac metastasis. Compared with 12 non-aggressive tumors, the aggressive cases had larger tumor size (more than 9 cm) with a thicker capsule (more than 2 mm). In studies to investigate the prognostic index using nucleolar organizing region (NOR), proliferating cell nuclear antigen (PCNA) and flow cytometry as well as nuclear grade and mitotic index, we could not find the useful parameter to detect the malignant potential of PCTP. In the flow cytometric analysis of cellular DNA contents, two invasive cases and the only one case of the male patient among the non-aggressive group were aneuploid. In conclusion, although it is hard to predict the prognosis by microscopic findings only, those with a thick capsule and aneuploidy tend to be related to malignant potential.",
author = "Cho, {N. H.} and Go, {J. H.} and Jung, {S. H.} and Jung, {W. H.} and Lee, {K. K.}",
year = "1995",
month = "10",
doi = "10.3346/jkms.1995.10.5.342",
language = "English",
volume = "10",
pages = "342--351",
journal = "Journal of Korean Medical Science",
issn = "1011-8934",
publisher = "Korean Academy of Medical Science",
number = "5",

}

Correlation between proliferating index and prognostic factors in papillary cystic tumors of the pancreas. / Cho, N. H.; Go, J. H.; Jung, S. H.; Jung, W. H.; Lee, K. K.

In: Journal of Korean medical science, Vol. 10, No. 5, 10.1995, p. 342-351.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Correlation between proliferating index and prognostic factors in papillary cystic tumors of the pancreas.

AU - Cho, N. H.

AU - Go, J. H.

AU - Jung, S. H.

AU - Jung, W. H.

AU - Lee, K. K.

PY - 1995/10

Y1 - 1995/10

N2 - Fifteen cases of papillary cystic tumor of the pancreas (PCTP) were studied (14 female patients, one male patient; mean age: 23.5 years). Most tumors developed in the head of the pancreas as a well circumscribed large mass. The tumor had a mean diameter of 6.7 cm(range; 2 to 15 cm). Histopathologically abundant delicate papillary fragments, monomorphic tumor cells and degenerative changes of the solid area of the tumor were characteristic. All but two cases had completely circumscribed capsules. Two cases had duodenal invasion; one of all cases had cul de sac metastasis. Compared with 12 non-aggressive tumors, the aggressive cases had larger tumor size (more than 9 cm) with a thicker capsule (more than 2 mm). In studies to investigate the prognostic index using nucleolar organizing region (NOR), proliferating cell nuclear antigen (PCNA) and flow cytometry as well as nuclear grade and mitotic index, we could not find the useful parameter to detect the malignant potential of PCTP. In the flow cytometric analysis of cellular DNA contents, two invasive cases and the only one case of the male patient among the non-aggressive group were aneuploid. In conclusion, although it is hard to predict the prognosis by microscopic findings only, those with a thick capsule and aneuploidy tend to be related to malignant potential.

AB - Fifteen cases of papillary cystic tumor of the pancreas (PCTP) were studied (14 female patients, one male patient; mean age: 23.5 years). Most tumors developed in the head of the pancreas as a well circumscribed large mass. The tumor had a mean diameter of 6.7 cm(range; 2 to 15 cm). Histopathologically abundant delicate papillary fragments, monomorphic tumor cells and degenerative changes of the solid area of the tumor were characteristic. All but two cases had completely circumscribed capsules. Two cases had duodenal invasion; one of all cases had cul de sac metastasis. Compared with 12 non-aggressive tumors, the aggressive cases had larger tumor size (more than 9 cm) with a thicker capsule (more than 2 mm). In studies to investigate the prognostic index using nucleolar organizing region (NOR), proliferating cell nuclear antigen (PCNA) and flow cytometry as well as nuclear grade and mitotic index, we could not find the useful parameter to detect the malignant potential of PCTP. In the flow cytometric analysis of cellular DNA contents, two invasive cases and the only one case of the male patient among the non-aggressive group were aneuploid. In conclusion, although it is hard to predict the prognosis by microscopic findings only, those with a thick capsule and aneuploidy tend to be related to malignant potential.

UR - http://www.scopus.com/inward/record.url?scp=0029382755&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029382755&partnerID=8YFLogxK

U2 - 10.3346/jkms.1995.10.5.342

DO - 10.3346/jkms.1995.10.5.342

M3 - Article

C2 - 8750060

AN - SCOPUS:0029382755

VL - 10

SP - 342

EP - 351

JO - Journal of Korean Medical Science

JF - Journal of Korean Medical Science

SN - 1011-8934

IS - 5

ER -