Correlation of cyclooxygenase-2 expression and microvessel density with prognosis in transitional cell carcinoma of the upper urinary tract

Min Ho Cha, Dae Sung Cho, Hyunee Yim, Kang Su Cho, Sung Joon Hong, Nam Hoon Cho, Sun Il Kim, Hyun Soo Ahn, Se Joong Kim

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Abstract

Purpose: The aim of this study was to investigate the relationship of cyclooxygenase (COX)-2 expression and microvessel density (MVD), a reflection of angiogenesis, with prognosis in patients with transitional cell carcinoma of the upper urinary tract (TCC-UUT). Materials and Methods: Formalin-fixed, paraffin-embedded tissue sections of TCC-UUT from 91 patients, who had undergone radical nephroureterectomy, were examined immunohistochemically using antibodies against COX-2 and CD34. MVD was determined with CD34-stained slides. The expression patterns of COX-2 and MVD were compared with the clinicopathological variables. Results: The COX-2 expression was significantly correlated with T stage (p=0.002), N stage (p=0.010), and grade (p=0.027). MVD was also significantly correlated with T stage (p < 0.001), N stage (p=0.002), and grade (p=0.001). The COX-2 expression was significantly correlated with MVD (p=0.001). The survival rate of patients with COX-2 positive tumors or high MVD was significantly lower than that of patients with COX-2 negative tumors or low MVD, respectively (p=0.0013, p=0.0312). Univariate analyses identified T stage, N stage, grade, COX-2 expression, and MVD as significant prognostic factors for cancer-specific survival; multivariate analyses indicated that T stage was the only independent prognostic factor. Conclusions: The increased expression of COX-2 and MVD is associated with a worse prognosis in TCC-UUT. The COX-2 expression is correlated with MVD. These results suggest that COX-2 may play an important role in the progression of TCC-UUT and angiogenesis may be affected by COX-2 during the progression of TCC-UUT.

Original languageEnglish
Pages (from-to)376-382
Number of pages7
JournalKorean Journal of Urology
Volume48
Issue number4
DOIs
Publication statusPublished - 2007 Apr

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All Science Journal Classification (ASJC) codes

  • Urology

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