Correlation of human leukocyte antigen-g (hla-g) expression and disease progression in epithelial ovarian cancer

Yong Wook Jung, Young Tae Kim, Sang Wun Kim, Sunghoon Kim, Jae Hoon Kim, Nam Hoon Cho, Jae Wook Kim

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Human leukocyte antigen-G (HLA-G) expression has been reported to be relevant to cancer development and immune tolerance. The purpose of this study was to investigate the correlation between HLA-G expression and disease progression and to assess the use of HLA-G expression as a prognostic immunomarker in epithelial ovarian carcinoma. Human leukocyte antigen-G expression in 41 ovarian cancer tissues and 8 normal ovarian tissues was analyzed using immunohistochemistry and Western blot assay. Quantitative real-time reverse transcription polymerase chain reaction (RT-PCR) was used for HLA-G messenger RNA (mRNA) expression. Human leukocyte antigen-G mRNA and protein levels were significantly greater in advanced ovarian cancer tissues than in normal or early stage ovarian cancer tissues (P <.05 and P <.05, respectively). Patients with HLA-G expression had a significantly worse prognosis. There is a significant correlation between HLA-G immunoreactivity and patient survival in univariate analysis (P =.04). Our data was consistent with the concept that HLA-G expression might play a pivotal role in the development and disease progression of epithelial ovarian cancer.

Original languageEnglish
Pages (from-to)1103-1111
Number of pages9
JournalReproductive Sciences
Volume16
Issue number11
DOIs
Publication statusPublished - 2009 Nov

All Science Journal Classification (ASJC) codes

  • Obstetrics and Gynaecology

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