Correlation of the oxygen radical activity and antioxidants and severity in critically ill surgical patients - study protocol

Hongjin Shim, Ji Young Jang, Seung Hwan Lee, JaeGil Lee

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Background: Surgical patients who require an emergent operation commonly have severe sepsis or septic shock, followed by high morbidity and mortality rates.Despite advances in treatment however, no predictable markers are available. In severe sepsis, many pathophysiologic mechanisms are involved in progression to organ failure, and oxygen free radical and antioxidants are known to contribute to this process. Oxygen free radical and antioxidants contribute to progression of organ failure in severe sepsis. In fact, oxygen radical activity has been reported to be correlated with disease severity and prognosis in patients with severe sepsis or septic shock. Accordingly, we aim to assess the usefulness of oxygen free radical and antioxidant concentrations to predict the disease severity and mortality in a cohort of critically ill surgical patients.Methods/Design: This is a prospective observation study including patient demographic characteristics, clinical information, blood sampling/serum oxygen radical activity, serum antioxidant activity, serum antioxidant concentrations (zinc, selenium and glutamate), disease severity scores, outcomes, lengths of stay in intensive care unit, hospital 30-day mortality.

Original languageEnglish
Article number18
JournalWorld Journal of Emergency Surgery
Volume8
Issue number1
DOIs
Publication statusPublished - 2013 May 3

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Critical Illness
Reactive Oxygen Species
Antioxidants
Sepsis
Free Radicals
Septic Shock
Mortality
Serum
Selenium
Intensive Care Units
Zinc
Glutamic Acid
Length of Stay
Observation
Demography
Prospective Studies
Morbidity
Therapeutics

All Science Journal Classification (ASJC) codes

  • Surgery
  • Emergency Medicine

Cite this

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abstract = "Background: Surgical patients who require an emergent operation commonly have severe sepsis or septic shock, followed by high morbidity and mortality rates.Despite advances in treatment however, no predictable markers are available. In severe sepsis, many pathophysiologic mechanisms are involved in progression to organ failure, and oxygen free radical and antioxidants are known to contribute to this process. Oxygen free radical and antioxidants contribute to progression of organ failure in severe sepsis. In fact, oxygen radical activity has been reported to be correlated with disease severity and prognosis in patients with severe sepsis or septic shock. Accordingly, we aim to assess the usefulness of oxygen free radical and antioxidant concentrations to predict the disease severity and mortality in a cohort of critically ill surgical patients.Methods/Design: This is a prospective observation study including patient demographic characteristics, clinical information, blood sampling/serum oxygen radical activity, serum antioxidant activity, serum antioxidant concentrations (zinc, selenium and glutamate), disease severity scores, outcomes, lengths of stay in intensive care unit, hospital 30-day mortality.",
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Correlation of the oxygen radical activity and antioxidants and severity in critically ill surgical patients - study protocol. / Shim, Hongjin; Jang, Ji Young; Lee, Seung Hwan; Lee, JaeGil.

In: World Journal of Emergency Surgery, Vol. 8, No. 1, 18, 03.05.2013.

Research output: Contribution to journalArticle

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AB - Background: Surgical patients who require an emergent operation commonly have severe sepsis or septic shock, followed by high morbidity and mortality rates.Despite advances in treatment however, no predictable markers are available. In severe sepsis, many pathophysiologic mechanisms are involved in progression to organ failure, and oxygen free radical and antioxidants are known to contribute to this process. Oxygen free radical and antioxidants contribute to progression of organ failure in severe sepsis. In fact, oxygen radical activity has been reported to be correlated with disease severity and prognosis in patients with severe sepsis or septic shock. Accordingly, we aim to assess the usefulness of oxygen free radical and antioxidant concentrations to predict the disease severity and mortality in a cohort of critically ill surgical patients.Methods/Design: This is a prospective observation study including patient demographic characteristics, clinical information, blood sampling/serum oxygen radical activity, serum antioxidant activity, serum antioxidant concentrations (zinc, selenium and glutamate), disease severity scores, outcomes, lengths of stay in intensive care unit, hospital 30-day mortality.

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