Correlation of tissue and blood plasminogen activation system in breast cancer

Sun Young Rha, Woo Ick Yang, Soo Jung Gong, Jin Ju Kim, Nae Choon Yoo, Jae Kyung Roh, Jin Sik Min, Kyong Sik Lee, Byung Soo Kim, Hyun Cheol Chung

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

The plasminogen activation system plays a crucial role during cancer invasion and metastasis. In the solid tumor, urokinase-type plasminogen activator (uPA), plasminogen activator inhibitor type-1 (PAI-1) and uPA receptor (uPAR) are considered as prognostic factors. In this study, we have investigated whether secretion of the uPA, PAI-1 and uPAR from the primary breast cancer tissue can be detected in the blood of the patients using the ELISA assay. We have found that the plasminogen activation system (uPA, PAI- 1, uPAR) of tumor tissue is activated from the early stage of breast cancer. However, only a number of metastatic lymph nodes was a prognostic factor in multivariate analysis for relapse. The blood level of the plasminogen activation system correlated with that of tissue in an order of uPAR (r2 = 0.61; P = 0.001), uPA (r2 = 0.35; P = 0.001) and PAI-1 (r2 = 0.11; P = 0.001). We conclude that the total uPAR level of cancer tissue can be substituted by that which is detected in the blood for further clinical applications. (C) 2000 Elsevier Science Ireland Ltd.

Original languageEnglish
Pages (from-to)137-145
Number of pages9
JournalCancer Letters
Volume150
Issue number2
DOIs
Publication statusPublished - 2000 Mar 31

    Fingerprint

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Rha, S. Y., Yang, W. I., Gong, S. J., Kim, J. J., Yoo, N. C., Roh, J. K., Min, J. S., Lee, K. S., Kim, B. S., & Chung, H. C. (2000). Correlation of tissue and blood plasminogen activation system in breast cancer. Cancer Letters, 150(2), 137-145. https://doi.org/10.1016/S0304-3835(99)00376-6