Correlations between neuronal loss, decrease of memory, and decrease expression of brain-derived neurotrophic factor in the gerbil hippocampus during normal aging

In Koo Hwang; Ki Yeon Yoo; Boo Kyoung Jung; Jun Hwi Cho; Do Hoon Kim; Tae Cheon Kang; Young Guen Kwon; Yong Sun Kim; Moo Ho Won

doi:10.1016/j.expneurol.2006.02.129

Correlations between neuronal loss, decrease of memory, and decrease expression of brain-derived neurotrophic factor in the gerbil hippocampus during normal aging

In Koo Hwang, Ki Yeon Yoo, Boo Kyoung Jung, Jun Hwi Cho, Do Hoon Kim, Tae Cheon Kang, Young Guen Kwon, Yong Sun Kim, Moo Ho Won

Research output: Contribution to journal › Article › peer-review

41 Citations (Scopus)

Abstract

It is known that the hippocampus has vital functions in learning and memory, behavioral regulation, and activity-dependent synaptic plasticity, and that the hippocampus contains high levels of brain-derived neurotrophic factor (BDNF). In the present study, we followed age-dependent changes of BDNF immunoreactivity and protein level in the gerbil hippocampus to identify the correlation between BDNF and aging. BDNF immunoreactivity and its protein level significantly increased at postnatal month (PM) 12 in the hippocampus and thereafter reduced. At PM 24, BDNF immunoreactivity in the hippocampal CA1 region and dentate gyrus was similar to that in the PM 1 group, whereas BDNF immunoreactivity in the CA2/3 region at PM 24 was higher than that at PM 1. In the PM 24 group, an age-related neuronal loss and the decrease of reference and working memory were observed. In conclusion, our results suggest that observed reduction in BDNF and reference memory may be associated with age-dependent neuronal loss in the hippocampal CA1 region.

Original language	English
Pages (from-to)	75-83
Number of pages	9
Journal	Experimental Neurology
Volume	201
Issue number	1
DOIs	https://doi.org/10.1016/j.expneurol.2006.02.129
Publication status	Published - 2006 Sept

Bibliographical note

Funding Information:
The authors would like to thank Mr. Seok Han, Mr. Seung Uk Lee, and Ms. Hyun Sook Kim for their technical help for this study. This study was supported by a grant from the Korea Health 21 R&D Project, Ministry of Health and Welfare, Republic of Korea (A020007).

All Science Journal Classification (ASJC) codes

Neurology
Developmental Neuroscience

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10.1016/j.expneurol.2006.02.129

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Hwang, I. K., Yoo, K. Y., Jung, B. K., Cho, J. H., Kim, D. H., Kang, T. C., Kwon, Y. G., Kim, Y. S., & Won, M. H. (2006). Correlations between neuronal loss, decrease of memory, and decrease expression of brain-derived neurotrophic factor in the gerbil hippocampus during normal aging. Experimental Neurology, 201(1), 75-83. https://doi.org/10.1016/j.expneurol.2006.02.129

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abstract = "It is known that the hippocampus has vital functions in learning and memory, behavioral regulation, and activity-dependent synaptic plasticity, and that the hippocampus contains high levels of brain-derived neurotrophic factor (BDNF). In the present study, we followed age-dependent changes of BDNF immunoreactivity and protein level in the gerbil hippocampus to identify the correlation between BDNF and aging. BDNF immunoreactivity and its protein level significantly increased at postnatal month (PM) 12 in the hippocampus and thereafter reduced. At PM 24, BDNF immunoreactivity in the hippocampal CA1 region and dentate gyrus was similar to that in the PM 1 group, whereas BDNF immunoreactivity in the CA2/3 region at PM 24 was higher than that at PM 1. In the PM 24 group, an age-related neuronal loss and the decrease of reference and working memory were observed. In conclusion, our results suggest that observed reduction in BDNF and reference memory may be associated with age-dependent neuronal loss in the hippocampal CA1 region.",

author = "Hwang, {In Koo} and Yoo, {Ki Yeon} and Jung, {Boo Kyoung} and Cho, {Jun Hwi} and Kim, {Do Hoon} and Kang, {Tae Cheon} and Kwon, {Young Guen} and Kim, {Yong Sun} and Won, {Moo Ho}",

note = "Funding Information: The authors would like to thank Mr. Seok Han, Mr. Seung Uk Lee, and Ms. Hyun Sook Kim for their technical help for this study. This study was supported by a grant from the Korea Health 21 R&D Project, Ministry of Health and Welfare, Republic of Korea (A020007).",

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AU - Kim, Do Hoon

AU - Kang, Tae Cheon

AU - Kwon, Young Guen

AU - Kim, Yong Sun

AU - Won, Moo Ho

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N2 - It is known that the hippocampus has vital functions in learning and memory, behavioral regulation, and activity-dependent synaptic plasticity, and that the hippocampus contains high levels of brain-derived neurotrophic factor (BDNF). In the present study, we followed age-dependent changes of BDNF immunoreactivity and protein level in the gerbil hippocampus to identify the correlation between BDNF and aging. BDNF immunoreactivity and its protein level significantly increased at postnatal month (PM) 12 in the hippocampus and thereafter reduced. At PM 24, BDNF immunoreactivity in the hippocampal CA1 region and dentate gyrus was similar to that in the PM 1 group, whereas BDNF immunoreactivity in the CA2/3 region at PM 24 was higher than that at PM 1. In the PM 24 group, an age-related neuronal loss and the decrease of reference and working memory were observed. In conclusion, our results suggest that observed reduction in BDNF and reference memory may be associated with age-dependent neuronal loss in the hippocampal CA1 region.

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Correlations between neuronal loss, decrease of memory, and decrease expression of brain-derived neurotrophic factor in the gerbil hippocampus during normal aging

Abstract

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