Correlations of amyloid-β concentrations between CSF and plasma in acute Alzheimer mouse model

Soo Min Cho, Hyunjin Vincent Kim, Sejin Lee, Hye Yun Kim, Woong Kim, Tae Song Kim, Dong Jin Kim, Young Soo Kim

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Amyloid-β (Aβ) is one of the few neuropathological biomarkers associated with transporters of the blood-brain barrier (BBB). Despite the well-characterized clinical indication of decreasing Aβ levels in the cerebrospinal fluid (CSF) during the development of Alzheimer's disease (AD), the link between the alternation of Aβ level in the blood and the progress of the disorder is still controversial. Here, we report a direct correlation of Aβ(1-42) levels between CSF and plasma in AD mouse model. We injected monomeric Aβ(1-42) directly into the intracerebroventricular (ICV) region of normal adult mouse brains to induce AD-like phenotypes. Using sandwich enzyme-linked immunosorbent assays, we observed proportional elevation of Aβ(1-42) levels in both CSF and plasma in a dose-dependent manner. Our findings that plasma Aβ(1-42) reflects the condition of CSF Aβ(1-42) warrant further investigation as a biomarker for the blood diagnosis of AD.

Original languageEnglish
Article number6777
JournalScientific reports
Volume4
DOIs
Publication statusPublished - 2014 Oct 27

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Amyloid
Cerebrospinal Fluid
Alzheimer Disease
Biomarkers
Blood-Brain Barrier
Enzyme-Linked Immunosorbent Assay
Phenotype
Brain

All Science Journal Classification (ASJC) codes

  • General

Cite this

Cho, Soo Min ; Kim, Hyunjin Vincent ; Lee, Sejin ; Kim, Hye Yun ; Kim, Woong ; Kim, Tae Song ; Kim, Dong Jin ; Kim, Young Soo. / Correlations of amyloid-β concentrations between CSF and plasma in acute Alzheimer mouse model. In: Scientific reports. 2014 ; Vol. 4.
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Correlations of amyloid-β concentrations between CSF and plasma in acute Alzheimer mouse model. / Cho, Soo Min; Kim, Hyunjin Vincent; Lee, Sejin; Kim, Hye Yun; Kim, Woong; Kim, Tae Song; Kim, Dong Jin; Kim, Young Soo.

In: Scientific reports, Vol. 4, 6777, 27.10.2014.

Research output: Contribution to journalArticle

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