Correlations of C-reactive protein levels and erythrocyte sedimentation rates with endoscopic activity indices in patients with ulcerative colitis

Jin Young Yoon, Soo Jung Park, Sung Pil Hong, Tae Il Kim, Won Ho Kim, JaeHee Cheon

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Background: Accurate assessment of endoscopic severity is essential to the early detection of relapses and treatment of patients with ulcerative colitis (UC). However, the relationships between non-invasive biomarkers and invasive endoscopic severity indices remain poorly understood. Methods: A total of 722 endoscopies in 552 patients were evaluated in this study. Endoscopic activity was assessed using five widely used endoscopic scoring systems: the Powell-Tuck assessment, Mayo Endoscopic Score, modified Baron Score, Rachmilewitz Endoscopic Activity Index, and Hanauer's Sigmoidoscopic Index. These five indices were compared with two non-invasive biomarkers, erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) levels. Results: The Pearson's correlation coefficients of CRP and ESR with endoscopic indices were r = 0.457 and 0.342 in the Powell-Tuck assessment, r = 0.503 and r = 0.402 in the Mayo Endoscopic Score, r = 0.507 and 0.408 in Hanauer's Sigmoidoscopic Index, r = 0.520 and 0.433 in the modified Baron Score, and r = 0.523 and 0.435 in the Rachmilewitz Endoscopic Activity Index. Sensitivity and specificity ranges for CRP and ESR were 50.5-53.3 % and 68.7-71.3 % and 85.1-87.2 % and 63.4-66.4 %, respectively, for the detection of endoscopic remission using the five endoscopic indices. Conclusions: CRP and ESR levels were modestly correlated with endoscopic activity indices in UC patients. However, the low sensitivities for detecting endoscopic remission suggest that CRP or ESR alone is not sufficient to reflect endoscopic severity accurately.

Original languageEnglish
Pages (from-to)829-837
Number of pages9
JournalDigestive Diseases and Sciences
Volume59
Issue number4
DOIs
Publication statusPublished - 2014 Jan 1

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Blood Sedimentation
Ulcerative Colitis
C-Reactive Protein
Biomarkers
Endoscopy
Recurrence
Sensitivity and Specificity

All Science Journal Classification (ASJC) codes

  • Physiology
  • Gastroenterology

Cite this

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title = "Correlations of C-reactive protein levels and erythrocyte sedimentation rates with endoscopic activity indices in patients with ulcerative colitis",
abstract = "Background: Accurate assessment of endoscopic severity is essential to the early detection of relapses and treatment of patients with ulcerative colitis (UC). However, the relationships between non-invasive biomarkers and invasive endoscopic severity indices remain poorly understood. Methods: A total of 722 endoscopies in 552 patients were evaluated in this study. Endoscopic activity was assessed using five widely used endoscopic scoring systems: the Powell-Tuck assessment, Mayo Endoscopic Score, modified Baron Score, Rachmilewitz Endoscopic Activity Index, and Hanauer's Sigmoidoscopic Index. These five indices were compared with two non-invasive biomarkers, erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) levels. Results: The Pearson's correlation coefficients of CRP and ESR with endoscopic indices were r = 0.457 and 0.342 in the Powell-Tuck assessment, r = 0.503 and r = 0.402 in the Mayo Endoscopic Score, r = 0.507 and 0.408 in Hanauer's Sigmoidoscopic Index, r = 0.520 and 0.433 in the modified Baron Score, and r = 0.523 and 0.435 in the Rachmilewitz Endoscopic Activity Index. Sensitivity and specificity ranges for CRP and ESR were 50.5-53.3 {\%} and 68.7-71.3 {\%} and 85.1-87.2 {\%} and 63.4-66.4 {\%}, respectively, for the detection of endoscopic remission using the five endoscopic indices. Conclusions: CRP and ESR levels were modestly correlated with endoscopic activity indices in UC patients. However, the low sensitivities for detecting endoscopic remission suggest that CRP or ESR alone is not sufficient to reflect endoscopic severity accurately.",
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Correlations of C-reactive protein levels and erythrocyte sedimentation rates with endoscopic activity indices in patients with ulcerative colitis. / Yoon, Jin Young; Park, Soo Jung; Hong, Sung Pil; Kim, Tae Il; Kim, Won Ho; Cheon, JaeHee.

In: Digestive Diseases and Sciences, Vol. 59, No. 4, 01.01.2014, p. 829-837.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Correlations of C-reactive protein levels and erythrocyte sedimentation rates with endoscopic activity indices in patients with ulcerative colitis

AU - Yoon, Jin Young

AU - Park, Soo Jung

AU - Hong, Sung Pil

AU - Kim, Tae Il

AU - Kim, Won Ho

AU - Cheon, JaeHee

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N2 - Background: Accurate assessment of endoscopic severity is essential to the early detection of relapses and treatment of patients with ulcerative colitis (UC). However, the relationships between non-invasive biomarkers and invasive endoscopic severity indices remain poorly understood. Methods: A total of 722 endoscopies in 552 patients were evaluated in this study. Endoscopic activity was assessed using five widely used endoscopic scoring systems: the Powell-Tuck assessment, Mayo Endoscopic Score, modified Baron Score, Rachmilewitz Endoscopic Activity Index, and Hanauer's Sigmoidoscopic Index. These five indices were compared with two non-invasive biomarkers, erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) levels. Results: The Pearson's correlation coefficients of CRP and ESR with endoscopic indices were r = 0.457 and 0.342 in the Powell-Tuck assessment, r = 0.503 and r = 0.402 in the Mayo Endoscopic Score, r = 0.507 and 0.408 in Hanauer's Sigmoidoscopic Index, r = 0.520 and 0.433 in the modified Baron Score, and r = 0.523 and 0.435 in the Rachmilewitz Endoscopic Activity Index. Sensitivity and specificity ranges for CRP and ESR were 50.5-53.3 % and 68.7-71.3 % and 85.1-87.2 % and 63.4-66.4 %, respectively, for the detection of endoscopic remission using the five endoscopic indices. Conclusions: CRP and ESR levels were modestly correlated with endoscopic activity indices in UC patients. However, the low sensitivities for detecting endoscopic remission suggest that CRP or ESR alone is not sufficient to reflect endoscopic severity accurately.

AB - Background: Accurate assessment of endoscopic severity is essential to the early detection of relapses and treatment of patients with ulcerative colitis (UC). However, the relationships between non-invasive biomarkers and invasive endoscopic severity indices remain poorly understood. Methods: A total of 722 endoscopies in 552 patients were evaluated in this study. Endoscopic activity was assessed using five widely used endoscopic scoring systems: the Powell-Tuck assessment, Mayo Endoscopic Score, modified Baron Score, Rachmilewitz Endoscopic Activity Index, and Hanauer's Sigmoidoscopic Index. These five indices were compared with two non-invasive biomarkers, erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) levels. Results: The Pearson's correlation coefficients of CRP and ESR with endoscopic indices were r = 0.457 and 0.342 in the Powell-Tuck assessment, r = 0.503 and r = 0.402 in the Mayo Endoscopic Score, r = 0.507 and 0.408 in Hanauer's Sigmoidoscopic Index, r = 0.520 and 0.433 in the modified Baron Score, and r = 0.523 and 0.435 in the Rachmilewitz Endoscopic Activity Index. Sensitivity and specificity ranges for CRP and ESR were 50.5-53.3 % and 68.7-71.3 % and 85.1-87.2 % and 63.4-66.4 %, respectively, for the detection of endoscopic remission using the five endoscopic indices. Conclusions: CRP and ESR levels were modestly correlated with endoscopic activity indices in UC patients. However, the low sensitivities for detecting endoscopic remission suggest that CRP or ESR alone is not sufficient to reflect endoscopic severity accurately.

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