Correlations of MR Sialographic Gradings with the Clinical Measures of Sjögren's Syndrome

Ara Cho, Ye Rin Lee, Yu Tae Jeon, Seung Hyun Chang, Young Min Park, Sung Jun Ahn, Jae Yol Lim

Research output: Contribution to journalArticlepeer-review


Objectives: Sjögren syndrome (SS) features salivary gland architectural changes such as ductal deformities and fat deposition secondary to inflammatory cell infiltrates; however, the anatomical and pathophysiological correlations of SS remain to be determined. This study aimed to determine the correlations of imaging findings based on the magnetic resonance (MR) sialography with the clinical and laboratory aspects of SS patients. Methods: We evaluated the MR sialographic findings of two pairs of parotid glands (PGs) and submandibular glands (SMGs) from 41 SS patients. The distinct MR sialographic features were then compared with the clinical symptoms, biological (anti-SSA/Ro antibody positivity), histological (labial gland focus score), and functional (salivary flow and scintigraphy) data. Results: Ductal deformities such as sialectasis in the PG ducts were exclusively observed in SS, and fat replacement in SMGs was more distinct in patients with SS than in non-SS sicca patients. Of the 82 PGs and SMGs from 41 SS patients, the grade of sialectasis in PGs on MR sialographic images and fat stage in SMGs showed strong correlations with anti-SSA/Ro-positivity. PG sialectasis was found more frequently in patients with dry mouth and decreased salivary gland function. A significant correlation was found between fat deposition in PGs and SMGs and decreased salivary gland function. Conclusion: These results suggest that MR sialography is a reliable, adjunctive anatomical and functional study to assess SS. Detail aspects of sialectasis and fat accumulation encountered on MR sialography in SS patients can help physicians assume the disease status in SS. Level of Evidence: 3 Laryngoscope, 133:307–316, 2023.

Original languageEnglish
Pages (from-to)307-316
Number of pages10
Issue number2
Publication statusPublished - 2023 Feb

Bibliographical note

Funding Information:
This research was supported by the Bio & Medical Technology Development Program of the National Research Foundation (NRF) funded by the Ministry of Science & ICT (NRF‐2020M3A9I4039045).

Publisher Copyright:
© 2022 The American Laryngological, Rhinological and Otological Society, Inc.

All Science Journal Classification (ASJC) codes

  • Otorhinolaryngology


Dive into the research topics of 'Correlations of MR Sialographic Gradings with the Clinical Measures of Sjögren's Syndrome'. Together they form a unique fingerprint.

Cite this