Cortical thickness and hippocampal shape in pure vascular mild cognitive impairment and dementia of subcortical type

H. J. Kim, B. S. Ye, C. W. Yoon, Y. Noh, G. H. Kim, H. Cho, S. Jeon, J. M. Lee, J. H. Kim, J. K. Seong, C. H. Kim, Y. S. Choe, K. H. Lee, S. T. Kim, J. S. Kim, S. E. Park, J. H. Kim, J. Chin, J. Cho, Changsoo Kim & 4 others J. H. Lee, M. W. Weiner, D. L. Na, S. W. Seo

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Abstract

Background and purpose: The progression pattern of brain structural changes in patients with isolated cerebrovascular disease (CVD) remains unclear. To investigate the role of isolated CVD in cognitive impairment patients, patterns of cortical thinning and hippocampal atrophy in pure subcortical vascular mild cognitive impairment (svMCI) and pure subcortical vascular dementia (SVaD) patients were characterized. Methods: Forty-five patients with svMCI and 46 patients with SVaD who were negative on Pittsburgh compound B (PiB) positron emission tomography imaging and 75 individuals with normal cognition (NC) were recruited. Results: Compared with NC, patients with PiB(-) svMCI exhibited frontal, language and retrieval type memory dysfunctions, which in patients with PiB(-) SVaD were further impaired and accompanied by visuospatial and recognition memory dysfunctions. Compared with NC, patients with PiB(-) svMCI exhibited cortical thinning in the frontal, perisylvian, basal temporal and posterior cingulate regions. This atrophy was more prominent and extended further toward the lateral parietal and medial temporal regions in patients with PiB(-) SVaD. Compared with NC subjects, patients with PiB(-) svMCI exhibited hippocampal shape deformities in the lateral body, whilst patients with PiB(-) SVaD exhibited additional deformities within the lateral head and inferior body. Conclusions: Our findings suggest that patients with CVD in the absence of Alzheimer's disease pathology can be demented, showing cognitive impairment in multiple domains, which is consistent with the topography of cortical thinning and hippocampal shape deformity.

Original languageEnglish
Pages (from-to)744-751
Number of pages8
JournalEuropean Journal of Neurology
Volume21
Issue number5
DOIs
Publication statusPublished - 2014 Jan 1

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Blood Vessels
Dementia
Vascular Dementia
Cerebrovascular Disorders
Cognition
Atrophy
Cognitive Dysfunction
Gyrus Cinguli
Temporal Lobe
2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole
Positron-Emission Tomography
Alzheimer Disease
Language
Pathology
Brain

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

Cite this

Kim, H. J. ; Ye, B. S. ; Yoon, C. W. ; Noh, Y. ; Kim, G. H. ; Cho, H. ; Jeon, S. ; Lee, J. M. ; Kim, J. H. ; Seong, J. K. ; Kim, C. H. ; Choe, Y. S. ; Lee, K. H. ; Kim, S. T. ; Kim, J. S. ; Park, S. E. ; Kim, J. H. ; Chin, J. ; Cho, J. ; Kim, Changsoo ; Lee, J. H. ; Weiner, M. W. ; Na, D. L. ; Seo, S. W. / Cortical thickness and hippocampal shape in pure vascular mild cognitive impairment and dementia of subcortical type. In: European Journal of Neurology. 2014 ; Vol. 21, No. 5. pp. 744-751.
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abstract = "Background and purpose: The progression pattern of brain structural changes in patients with isolated cerebrovascular disease (CVD) remains unclear. To investigate the role of isolated CVD in cognitive impairment patients, patterns of cortical thinning and hippocampal atrophy in pure subcortical vascular mild cognitive impairment (svMCI) and pure subcortical vascular dementia (SVaD) patients were characterized. Methods: Forty-five patients with svMCI and 46 patients with SVaD who were negative on Pittsburgh compound B (PiB) positron emission tomography imaging and 75 individuals with normal cognition (NC) were recruited. Results: Compared with NC, patients with PiB(-) svMCI exhibited frontal, language and retrieval type memory dysfunctions, which in patients with PiB(-) SVaD were further impaired and accompanied by visuospatial and recognition memory dysfunctions. Compared with NC, patients with PiB(-) svMCI exhibited cortical thinning in the frontal, perisylvian, basal temporal and posterior cingulate regions. This atrophy was more prominent and extended further toward the lateral parietal and medial temporal regions in patients with PiB(-) SVaD. Compared with NC subjects, patients with PiB(-) svMCI exhibited hippocampal shape deformities in the lateral body, whilst patients with PiB(-) SVaD exhibited additional deformities within the lateral head and inferior body. Conclusions: Our findings suggest that patients with CVD in the absence of Alzheimer's disease pathology can be demented, showing cognitive impairment in multiple domains, which is consistent with the topography of cortical thinning and hippocampal shape deformity.",
author = "Kim, {H. J.} and Ye, {B. S.} and Yoon, {C. W.} and Y. Noh and Kim, {G. H.} and H. Cho and S. Jeon and Lee, {J. M.} and Kim, {J. H.} and Seong, {J. K.} and Kim, {C. H.} and Choe, {Y. S.} and Lee, {K. H.} and Kim, {S. T.} and Kim, {J. S.} and Park, {S. E.} and Kim, {J. H.} and J. Chin and J. Cho and Changsoo Kim and Lee, {J. H.} and Weiner, {M. W.} and Na, {D. L.} and Seo, {S. W.}",
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Kim, HJ, Ye, BS, Yoon, CW, Noh, Y, Kim, GH, Cho, H, Jeon, S, Lee, JM, Kim, JH, Seong, JK, Kim, CH, Choe, YS, Lee, KH, Kim, ST, Kim, JS, Park, SE, Kim, JH, Chin, J, Cho, J, Kim, C, Lee, JH, Weiner, MW, Na, DL & Seo, SW 2014, 'Cortical thickness and hippocampal shape in pure vascular mild cognitive impairment and dementia of subcortical type', European Journal of Neurology, vol. 21, no. 5, pp. 744-751. https://doi.org/10.1111/ene.12376

Cortical thickness and hippocampal shape in pure vascular mild cognitive impairment and dementia of subcortical type. / Kim, H. J.; Ye, B. S.; Yoon, C. W.; Noh, Y.; Kim, G. H.; Cho, H.; Jeon, S.; Lee, J. M.; Kim, J. H.; Seong, J. K.; Kim, C. H.; Choe, Y. S.; Lee, K. H.; Kim, S. T.; Kim, J. S.; Park, S. E.; Kim, J. H.; Chin, J.; Cho, J.; Kim, Changsoo; Lee, J. H.; Weiner, M. W.; Na, D. L.; Seo, S. W.

In: European Journal of Neurology, Vol. 21, No. 5, 01.01.2014, p. 744-751.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Cortical thickness and hippocampal shape in pure vascular mild cognitive impairment and dementia of subcortical type

AU - Kim, H. J.

AU - Ye, B. S.

AU - Yoon, C. W.

AU - Noh, Y.

AU - Kim, G. H.

AU - Cho, H.

AU - Jeon, S.

AU - Lee, J. M.

AU - Kim, J. H.

AU - Seong, J. K.

AU - Kim, C. H.

AU - Choe, Y. S.

AU - Lee, K. H.

AU - Kim, S. T.

AU - Kim, J. S.

AU - Park, S. E.

AU - Kim, J. H.

AU - Chin, J.

AU - Cho, J.

AU - Kim, Changsoo

AU - Lee, J. H.

AU - Weiner, M. W.

AU - Na, D. L.

AU - Seo, S. W.

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Background and purpose: The progression pattern of brain structural changes in patients with isolated cerebrovascular disease (CVD) remains unclear. To investigate the role of isolated CVD in cognitive impairment patients, patterns of cortical thinning and hippocampal atrophy in pure subcortical vascular mild cognitive impairment (svMCI) and pure subcortical vascular dementia (SVaD) patients were characterized. Methods: Forty-five patients with svMCI and 46 patients with SVaD who were negative on Pittsburgh compound B (PiB) positron emission tomography imaging and 75 individuals with normal cognition (NC) were recruited. Results: Compared with NC, patients with PiB(-) svMCI exhibited frontal, language and retrieval type memory dysfunctions, which in patients with PiB(-) SVaD were further impaired and accompanied by visuospatial and recognition memory dysfunctions. Compared with NC, patients with PiB(-) svMCI exhibited cortical thinning in the frontal, perisylvian, basal temporal and posterior cingulate regions. This atrophy was more prominent and extended further toward the lateral parietal and medial temporal regions in patients with PiB(-) SVaD. Compared with NC subjects, patients with PiB(-) svMCI exhibited hippocampal shape deformities in the lateral body, whilst patients with PiB(-) SVaD exhibited additional deformities within the lateral head and inferior body. Conclusions: Our findings suggest that patients with CVD in the absence of Alzheimer's disease pathology can be demented, showing cognitive impairment in multiple domains, which is consistent with the topography of cortical thinning and hippocampal shape deformity.

AB - Background and purpose: The progression pattern of brain structural changes in patients with isolated cerebrovascular disease (CVD) remains unclear. To investigate the role of isolated CVD in cognitive impairment patients, patterns of cortical thinning and hippocampal atrophy in pure subcortical vascular mild cognitive impairment (svMCI) and pure subcortical vascular dementia (SVaD) patients were characterized. Methods: Forty-five patients with svMCI and 46 patients with SVaD who were negative on Pittsburgh compound B (PiB) positron emission tomography imaging and 75 individuals with normal cognition (NC) were recruited. Results: Compared with NC, patients with PiB(-) svMCI exhibited frontal, language and retrieval type memory dysfunctions, which in patients with PiB(-) SVaD were further impaired and accompanied by visuospatial and recognition memory dysfunctions. Compared with NC, patients with PiB(-) svMCI exhibited cortical thinning in the frontal, perisylvian, basal temporal and posterior cingulate regions. This atrophy was more prominent and extended further toward the lateral parietal and medial temporal regions in patients with PiB(-) SVaD. Compared with NC subjects, patients with PiB(-) svMCI exhibited hippocampal shape deformities in the lateral body, whilst patients with PiB(-) SVaD exhibited additional deformities within the lateral head and inferior body. Conclusions: Our findings suggest that patients with CVD in the absence of Alzheimer's disease pathology can be demented, showing cognitive impairment in multiple domains, which is consistent with the topography of cortical thinning and hippocampal shape deformity.

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U2 - 10.1111/ene.12376

DO - 10.1111/ene.12376

M3 - Article

VL - 21

SP - 744

EP - 751

JO - European Journal of Neurology

JF - European Journal of Neurology

SN - 1351-5101

IS - 5

ER -