Corticospinal disinhibition in paroxysmal kinesigenic dyskinesia

S. Y. Kang; Y. H. Sohn; H. S. Kim; C. H. Lyoo; M. S. Lee

doi:10.1016/j.clinph.2005.09.007

Corticospinal disinhibition in paroxysmal kinesigenic dyskinesia

S. Y. Kang, Y. H. Sohn, H. S. Kim, C. H. Lyoo, M. S. Lee

Department of Neurology

Research output: Contribution to journal › Article

18 Citations (Scopus)

Abstract

Objective: To investigate the underlying mechanism responsible for paroxysmal kinesigenic dyskinesia (PKD). Methods: We performed a transcranial magnetic stimulation (TMS) study in 12 drug-naïve patients with PKD and 10 healthy volunteers. TMS parameters included resting motor threshold, recruitment curve of motor evoked potential amplitudes, short intracortical inhibition and facilitation, long intracortical inhibition (LICI), and silent period. We also measured compound muscle action potential. Results: LICI, representing GABA-mediated inhibition, was significantly reduced in the patients (P=0.033), while results for all other TMS parameters tested were comparable between the two groups. Conclusions and significance: These results suggest that a specific type of corticospinal inhibitory mechanism is impaired in patients with PKD.

Original language	English
Pages (from-to)	57-60
Number of pages	4
Journal	Clinical Neurophysiology
Volume	117
Issue number	1
DOIs	https://doi.org/10.1016/j.clinph.2005.09.007
Publication status	Published - 2006 Jan 1

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All Science Journal Classification (ASJC) codes

Sensory Systems
Neurology
Clinical Neurology
Physiology (medical)

Cite this

Kang, S. Y., Sohn, Y. H., Kim, H. S., Lyoo, C. H., & Lee, M. S. (2006). Corticospinal disinhibition in paroxysmal kinesigenic dyskinesia. Clinical Neurophysiology, 117(1), 57-60. https://doi.org/10.1016/j.clinph.2005.09.007

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10.1016/j.clinph.2005.09.007