TY - JOUR
T1 - Corticospinal disinhibition in paroxysmal kinesigenic dyskinesia
AU - Kang, S. Y.
AU - Sohn, Y. H.
AU - Kim, H. S.
AU - Lyoo, C. H.
AU - Lee, M. S.
PY - 2006/1
Y1 - 2006/1
N2 - Objective: To investigate the underlying mechanism responsible for paroxysmal kinesigenic dyskinesia (PKD). Methods: We performed a transcranial magnetic stimulation (TMS) study in 12 drug-naïve patients with PKD and 10 healthy volunteers. TMS parameters included resting motor threshold, recruitment curve of motor evoked potential amplitudes, short intracortical inhibition and facilitation, long intracortical inhibition (LICI), and silent period. We also measured compound muscle action potential. Results: LICI, representing GABA-mediated inhibition, was significantly reduced in the patients (P=0.033), while results for all other TMS parameters tested were comparable between the two groups. Conclusions and significance: These results suggest that a specific type of corticospinal inhibitory mechanism is impaired in patients with PKD.
AB - Objective: To investigate the underlying mechanism responsible for paroxysmal kinesigenic dyskinesia (PKD). Methods: We performed a transcranial magnetic stimulation (TMS) study in 12 drug-naïve patients with PKD and 10 healthy volunteers. TMS parameters included resting motor threshold, recruitment curve of motor evoked potential amplitudes, short intracortical inhibition and facilitation, long intracortical inhibition (LICI), and silent period. We also measured compound muscle action potential. Results: LICI, representing GABA-mediated inhibition, was significantly reduced in the patients (P=0.033), while results for all other TMS parameters tested were comparable between the two groups. Conclusions and significance: These results suggest that a specific type of corticospinal inhibitory mechanism is impaired in patients with PKD.
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U2 - 10.1016/j.clinph.2005.09.007
DO - 10.1016/j.clinph.2005.09.007
M3 - Article
C2 - 16314144
AN - SCOPUS:30744462049
VL - 117
SP - 57
EP - 60
JO - Electroencephalography and Clinical Neurophysiology - Electromyography and Motor Control
JF - Electroencephalography and Clinical Neurophysiology - Electromyography and Motor Control
SN - 1388-2457
IS - 1
ER -