Carbon dioxide is not only an important gaseous molecule for maintenance of the biosphere homeostasis, but is also a crucial signalling cue in living cells. Fungal pathogens, including Candida albicans and Cryptococcus neoformans, must adapt to dramatic changes in CO2 levels during colonization and subsequent infection of their human host. Recent reports provide insight into how pathogenic fungi sense environmental CO2 and the role of carbonic anhydrase and fungal adenylyl cyclase in CO2 sensing.
Bibliographical noteFunding Information:
The authors want to thank The Institute for Genomic Research (TIGR), Candida genome database (CGD), and Broad Institute (The Fungal Genome Initiative) for giving access to the annotated fungal genome database. This work was supported by the Soongsil University Research Fund (Y-S Bahn), the Wellcome Trust and European Union under the Interreg IIIA program (FA Mühlschlegel). FAM wishes to thank Sabine Eckert for input and critical discussions.
All Science Journal Classification (ASJC) codes
- Microbiology (medical)
- Infectious Diseases