Coupled Harmonic Bases for Longitudinal Characterization of Brain Networks

Seong Jae Hwang, Nagesh Adluru, Maxwell D. Collins, Sathya N. Ravi, Barbara B. Bendlin, Sterling C. Johnson, Vikas Singh

Research output: Chapter in Book/Report/Conference proceedingConference contribution

5 Citations (Scopus)

Abstract

There is a great deal of interest in using large scale brain imaging studies to understand how brain connectivity evolves over time for an individual and how it varies over different levels/quantiles of cognitive function. To do so, one typically performs so-called tractography procedures on diffusion MR brain images and derives measures of brain connectivity expressed as graphs. The nodes correspond to distinct brain regions and the edges encode the strength of the connection. The scientific interest is in characterizing the evolution of these graphs over time or from healthy individuals to diseased. We pose this important question in terms of the Laplacian of the connectivity graphs derived from various longitudinal or disease time points - quantifying its progression is then expressed in terms of coupling the harmonic bases of a full set of Laplacians. We derive a coupled system of generalized eigenvalue problems (and corresponding numerical optimization schemes) whose solution helps characterize the full life cycle of brain connectivity evolution in a given dataset. Finally, we show a set of results on a diffusion MR imaging dataset of middle aged people at risk for Alzheimer's disease (AD), who are cognitively healthy. In such asymptomatic adults, we find that a framework for characterizing brain connectivity evolution provides the ability to predict cognitive scores for individual subjects, and for estimating the progression of participant's brain connectivity into the future.

Original languageEnglish
Title of host publicationProceedings - 29th IEEE Conference on Computer Vision and Pattern Recognition, CVPR 2016
PublisherIEEE Computer Society
Pages2517-2525
Number of pages9
ISBN (Electronic)9781467388504
DOIs
Publication statusPublished - 2016 Dec 9
Event29th IEEE Conference on Computer Vision and Pattern Recognition, CVPR 2016 - Las Vegas, United States
Duration: 2016 Jun 262016 Jul 1

Publication series

NameProceedings of the IEEE Computer Society Conference on Computer Vision and Pattern Recognition
Volume2016-December
ISSN (Print)1063-6919

Conference

Conference29th IEEE Conference on Computer Vision and Pattern Recognition, CVPR 2016
Country/TerritoryUnited States
CityLas Vegas
Period16/6/2616/7/1

Bibliographical note

Publisher Copyright:
© 2016 IEEE.

All Science Journal Classification (ASJC) codes

  • Software
  • Computer Vision and Pattern Recognition

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