CpG island hypermethylator phenotype in gastric carcinoma and its clinicopathological features

Seog Yun Park, Myeong Cherl Kook, Young Woo Kim, Nam Yun Cho, Namhee Jung, Hyeong Ju Kwon, Tae You Kim, Gyeong Hoon Kang

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32 Citations (Scopus)

Abstract

Gastric carcinoma (GC) is one of the human cancers in which promoter CpG island hypermethylation is frequently found. CpG island methylator phenotype (CIMP) refers to a subset of GCs which harbor concordant methylation of multiple promoter CpG island loci. However, little is known regarding clinicopathological features of CIMP-positive (CIMP-high) GC. Our study aimed to characterize clinicopathological features of CIMP-high GC. We analyzed 196 cases of GCs for their methylation status in 16 cancer-specific CpG island loci using MethyLight assay and arbitrarily defined CIMP-high GC as those with methylation at 13 or more CpG island loci. With exclusion of microsatellite instability-positive GC and EBV-positive GC from the analysis, CIMP-high GC (n∈=∈10, 6.7%) demonstrated tendency toward higher cancer stage, infiltrative growth type, poor differentiation, and diffuse or mixed type of Lauren classification. CIMP-high GC showed significantly shortened survival compared with that of CIMP-negative GC. When CIMP-negative GC (methylation at 12 or less) was divided into CIMP-intermediate and CIMP-low (methylation at one or none), CIMP-low exhibited better clinical outcome than CIMP-intermediate. Hypermethylation at 14 CpG island loci or more was closely associated with poor clinical outcome and found to be an independent prognostic factor. Our findings that CIMP-high GCs were featured with characteristic clinicopathological parameters, including poor prognosis are distinct from previous studies. More extensive, large-scaled study is necessary to validate the findings of the present study.

Original languageEnglish
Pages (from-to)415-422
Number of pages8
JournalVirchows Archiv
Volume457
Issue number4
DOIs
Publication statusPublished - 2010 Oct 1

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All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Molecular Biology
  • Cell Biology

Cite this

Park, S. Y., Kook, M. C., Kim, Y. W., Cho, N. Y., Jung, N., Kwon, H. J., Kim, T. Y., & Kang, G. H. (2010). CpG island hypermethylator phenotype in gastric carcinoma and its clinicopathological features. Virchows Archiv, 457(4), 415-422. https://doi.org/10.1007/s00428-010-0962-0