CREB activates proteasomal degradation of DSCR1/RCAN1

Su Ryeon Seo, Kwang Chul Chung

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

The cyclic AMP response element-binding protein (CREB) is involved in the development and function of the nervous system. Here, we find that CREB decreases the protein level of Regulator of Calcineurin Activity 1 (RCAN1/DSCR1/MCIP1), which is overexpressed in the brain of Down Syndrome (DS) patients. Decrease of RCAN1 by CREB was blocked by proteasome inhibitors, indicating that this decrease is mediated by the ubiquitin-proteasome pathway. Furthermore, we found that the ability of CREB to activate the degradation of RCAN1 depends on its transcriptional activation. Consistently, CREB-enhanced the ubiquitination and turnover rate of RCAN1. Our results reveal a new regulatory role for CREB in DS pathology through the proteasomal degradation of RCAN1.

Original languageEnglish
Pages (from-to)1889-1893
Number of pages5
JournalFEBS Letters
Volume582
Issue number13
DOIs
Publication statusPublished - 2008 Jun 11

Fingerprint

Cyclic AMP Response Element-Binding Protein
Degradation
Down Syndrome
Proteasome Inhibitors
Calcineurin
Ubiquitination
Neurology
Pathology
Proteasome Endopeptidase Complex
Ubiquitin
Nervous System
Transcriptional Activation
Brain
Chemical activation
Proteins

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

Seo, Su Ryeon ; Chung, Kwang Chul. / CREB activates proteasomal degradation of DSCR1/RCAN1. In: FEBS Letters. 2008 ; Vol. 582, No. 13. pp. 1889-1893.
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CREB activates proteasomal degradation of DSCR1/RCAN1. / Seo, Su Ryeon; Chung, Kwang Chul.

In: FEBS Letters, Vol. 582, No. 13, 11.06.2008, p. 1889-1893.

Research output: Contribution to journalArticle

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