Cross-allergenicity of pollens from the Compositae family: Artemisia vulgaris, Dendranthema grandiflorum, and Taraxacum officinale

Won Lee Yong, Young Choi Soo, Kyung Lee Eun, Ho Sohn Jung, Jungwon Park, Chein Soo Hong

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Background: Chrysanthemum, dandelion, and mugwort belong to the Compositae (Asteraceae) family. Their cross-allergenicity has not yet been completely evaluated. Objective: To investigate the sensitization and cross-allergenicity of these 3 plants. Methods: We reviewed 6,497 respiratory allergic patients who underwent skin prick tests (SPTs) during the last 10 years (1995-2005) and analyzed the sensitization rates of the 3 pollens. We sorted this population by wheal size and selected the monosensitized or cosensitized patients. Their serum samples were used to evaluate specific IgE (sIgE) and cross-allergenicity of the 3 pollens by CAP, immunoblotting, and inhibition enzyme-linked immunosorbent assay (ELISA). Results: On SPTs, mugwort, chrysanthemum, and dandelion sensitized 13.4%, 10.0%, and 8.5% of the enrolled population, respectively, and 5.2% of the population was cosensitized to all 3 pollens. Some patients were monosensitized to 1 species (1.5% to chrysanthemum, 1.4% to dandelion, and 4.5% to mugwort). In inhibition ELISA that used a pooled serum sample cosensitized to all 3 pollens, mugwort inhibited slgE bindings to chrysanthemum, dandelion, and mugwort up to 95%, 86%, and 96%, respectively. The 50% inhibitory allergen concentrations for slgE to each of the 3 species were not different between solid-phase antigen and mugwort. The mugwort sIgE of this pooled serum was suppressed up to 74% and 27% by chrysanthemum and dandelion, respectively. The 50% inhibitory allergen concentrations of chrysanthemum and dandelion for mugwort sIgE were 0.3 and 57.0 μg/mL, respectively, whereas that of mugwort was 0.05 μg/mL. We found a patient who was truly monosensitized to dandelion. Conclusion: Chrysanthemum and dandelion were frequently cosensitized with mugwort in the general population with respiratory allergic diseases. These 2 species also showed extensive cross-allergenicity with mugwort. True monosensitization to these 2 species was possible.

Original languageEnglish
Pages (from-to)526-533
Number of pages8
JournalAnnals of Allergy, Asthma and Immunology
Volume99
Issue number6
Publication statusPublished - 2007 Jan 1

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Taraxacum
Artemisia
Asteraceae
Pollen
Chrysanthemum
Immunoglobulin E
Skin Tests
Allergens
Inhibitory Concentration 50
Serum
Enzyme-Linked Immunosorbent Assay
Population
Population Density
Immunoblotting

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Pulmonary and Respiratory Medicine

Cite this

Yong, Won Lee ; Soo, Young Choi ; Eun, Kyung Lee ; Jung, Ho Sohn ; Park, Jungwon ; Hong, Chein Soo. / Cross-allergenicity of pollens from the Compositae family : Artemisia vulgaris, Dendranthema grandiflorum, and Taraxacum officinale. In: Annals of Allergy, Asthma and Immunology. 2007 ; Vol. 99, No. 6. pp. 526-533.
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title = "Cross-allergenicity of pollens from the Compositae family: Artemisia vulgaris, Dendranthema grandiflorum, and Taraxacum officinale",
abstract = "Background: Chrysanthemum, dandelion, and mugwort belong to the Compositae (Asteraceae) family. Their cross-allergenicity has not yet been completely evaluated. Objective: To investigate the sensitization and cross-allergenicity of these 3 plants. Methods: We reviewed 6,497 respiratory allergic patients who underwent skin prick tests (SPTs) during the last 10 years (1995-2005) and analyzed the sensitization rates of the 3 pollens. We sorted this population by wheal size and selected the monosensitized or cosensitized patients. Their serum samples were used to evaluate specific IgE (sIgE) and cross-allergenicity of the 3 pollens by CAP, immunoblotting, and inhibition enzyme-linked immunosorbent assay (ELISA). Results: On SPTs, mugwort, chrysanthemum, and dandelion sensitized 13.4{\%}, 10.0{\%}, and 8.5{\%} of the enrolled population, respectively, and 5.2{\%} of the population was cosensitized to all 3 pollens. Some patients were monosensitized to 1 species (1.5{\%} to chrysanthemum, 1.4{\%} to dandelion, and 4.5{\%} to mugwort). In inhibition ELISA that used a pooled serum sample cosensitized to all 3 pollens, mugwort inhibited slgE bindings to chrysanthemum, dandelion, and mugwort up to 95{\%}, 86{\%}, and 96{\%}, respectively. The 50{\%} inhibitory allergen concentrations for slgE to each of the 3 species were not different between solid-phase antigen and mugwort. The mugwort sIgE of this pooled serum was suppressed up to 74{\%} and 27{\%} by chrysanthemum and dandelion, respectively. The 50{\%} inhibitory allergen concentrations of chrysanthemum and dandelion for mugwort sIgE were 0.3 and 57.0 μg/mL, respectively, whereas that of mugwort was 0.05 μg/mL. We found a patient who was truly monosensitized to dandelion. Conclusion: Chrysanthemum and dandelion were frequently cosensitized with mugwort in the general population with respiratory allergic diseases. These 2 species also showed extensive cross-allergenicity with mugwort. True monosensitization to these 2 species was possible.",
author = "Yong, {Won Lee} and Soo, {Young Choi} and Eun, {Kyung Lee} and Jung, {Ho Sohn} and Jungwon Park and Hong, {Chein Soo}",
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Cross-allergenicity of pollens from the Compositae family : Artemisia vulgaris, Dendranthema grandiflorum, and Taraxacum officinale. / Yong, Won Lee; Soo, Young Choi; Eun, Kyung Lee; Jung, Ho Sohn; Park, Jungwon; Hong, Chein Soo.

In: Annals of Allergy, Asthma and Immunology, Vol. 99, No. 6, 01.01.2007, p. 526-533.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Cross-allergenicity of pollens from the Compositae family

T2 - Artemisia vulgaris, Dendranthema grandiflorum, and Taraxacum officinale

AU - Yong, Won Lee

AU - Soo, Young Choi

AU - Eun, Kyung Lee

AU - Jung, Ho Sohn

AU - Park, Jungwon

AU - Hong, Chein Soo

PY - 2007/1/1

Y1 - 2007/1/1

N2 - Background: Chrysanthemum, dandelion, and mugwort belong to the Compositae (Asteraceae) family. Their cross-allergenicity has not yet been completely evaluated. Objective: To investigate the sensitization and cross-allergenicity of these 3 plants. Methods: We reviewed 6,497 respiratory allergic patients who underwent skin prick tests (SPTs) during the last 10 years (1995-2005) and analyzed the sensitization rates of the 3 pollens. We sorted this population by wheal size and selected the monosensitized or cosensitized patients. Their serum samples were used to evaluate specific IgE (sIgE) and cross-allergenicity of the 3 pollens by CAP, immunoblotting, and inhibition enzyme-linked immunosorbent assay (ELISA). Results: On SPTs, mugwort, chrysanthemum, and dandelion sensitized 13.4%, 10.0%, and 8.5% of the enrolled population, respectively, and 5.2% of the population was cosensitized to all 3 pollens. Some patients were monosensitized to 1 species (1.5% to chrysanthemum, 1.4% to dandelion, and 4.5% to mugwort). In inhibition ELISA that used a pooled serum sample cosensitized to all 3 pollens, mugwort inhibited slgE bindings to chrysanthemum, dandelion, and mugwort up to 95%, 86%, and 96%, respectively. The 50% inhibitory allergen concentrations for slgE to each of the 3 species were not different between solid-phase antigen and mugwort. The mugwort sIgE of this pooled serum was suppressed up to 74% and 27% by chrysanthemum and dandelion, respectively. The 50% inhibitory allergen concentrations of chrysanthemum and dandelion for mugwort sIgE were 0.3 and 57.0 μg/mL, respectively, whereas that of mugwort was 0.05 μg/mL. We found a patient who was truly monosensitized to dandelion. Conclusion: Chrysanthemum and dandelion were frequently cosensitized with mugwort in the general population with respiratory allergic diseases. These 2 species also showed extensive cross-allergenicity with mugwort. True monosensitization to these 2 species was possible.

AB - Background: Chrysanthemum, dandelion, and mugwort belong to the Compositae (Asteraceae) family. Their cross-allergenicity has not yet been completely evaluated. Objective: To investigate the sensitization and cross-allergenicity of these 3 plants. Methods: We reviewed 6,497 respiratory allergic patients who underwent skin prick tests (SPTs) during the last 10 years (1995-2005) and analyzed the sensitization rates of the 3 pollens. We sorted this population by wheal size and selected the monosensitized or cosensitized patients. Their serum samples were used to evaluate specific IgE (sIgE) and cross-allergenicity of the 3 pollens by CAP, immunoblotting, and inhibition enzyme-linked immunosorbent assay (ELISA). Results: On SPTs, mugwort, chrysanthemum, and dandelion sensitized 13.4%, 10.0%, and 8.5% of the enrolled population, respectively, and 5.2% of the population was cosensitized to all 3 pollens. Some patients were monosensitized to 1 species (1.5% to chrysanthemum, 1.4% to dandelion, and 4.5% to mugwort). In inhibition ELISA that used a pooled serum sample cosensitized to all 3 pollens, mugwort inhibited slgE bindings to chrysanthemum, dandelion, and mugwort up to 95%, 86%, and 96%, respectively. The 50% inhibitory allergen concentrations for slgE to each of the 3 species were not different between solid-phase antigen and mugwort. The mugwort sIgE of this pooled serum was suppressed up to 74% and 27% by chrysanthemum and dandelion, respectively. The 50% inhibitory allergen concentrations of chrysanthemum and dandelion for mugwort sIgE were 0.3 and 57.0 μg/mL, respectively, whereas that of mugwort was 0.05 μg/mL. We found a patient who was truly monosensitized to dandelion. Conclusion: Chrysanthemum and dandelion were frequently cosensitized with mugwort in the general population with respiratory allergic diseases. These 2 species also showed extensive cross-allergenicity with mugwort. True monosensitization to these 2 species was possible.

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