Crosstalk between GBM cells and mesenchymal stemlike cells promotes the invasiveness of GBM through the C5a/p38/ZEB1 axis

Eun Jung Lim, Seungmo Kim, Yoonjee Oh, Yongjoon Suh, Neha Kaushik, Ji Hyun Lee, Hae June Lee, Min Jung Kim, Myung Jin Park, Rae Kwon Kim, Junghwa Cha, Se Hoon Kim, Jin Kyoung Shim, Junjeong Choi, Jong Hee Chang, Yong Kil Hong, Yong Min Huh, Pilnam Kim, Seok Gu Kang, Su Jae Lee

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

Background. Mesenchymal stemlike cells (MSLCs) have been detected in many types of cancer including brain tumors and have received attention as stromal cells in the tumor microenvironment. However, the cellular mechanisms underlying their participation in cancer progression remain largely unexplored. The aim of this study was to determine whether MSLCs have a tumorigenic role in brain tumors. Methods. To figure out molecular and cellular mechanisms in glioma invasion, we have cultured glioma with MSLCs in a co-culture system. Results. Here, we show that MSLCs in human glioblastoma (GBM) secrete complement component C5a, which is known for its role as a complement factor. MSLC-secreted C5a increases expression of zinc finger E-box-binding homeobox 1 (ZEB1) via activation of p38 mitogen-activated protein kinase (MAPK) in GBM cells, thereby enhancing the invasion of GBM cells into parenchymal brain tissue. Conclusion. Our results reveal a mechanism by which MSLCs undergo crosstalk with GBM cells through the C5a/ p38 MAPK/ZEB1 signaling loop and act as a booster in GBM progression.

Original languageEnglish
Article numbernoaa064
Pages (from-to)1452-1462
Number of pages11
JournalNeuro-Oncology
Volume22
Issue number10
DOIs
Publication statusPublished - 2020 Oct 1

Bibliographical note

Publisher Copyright:
© The Author(s) 2020.

All Science Journal Classification (ASJC) codes

  • Oncology
  • Clinical Neurology
  • Cancer Research

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