Cryptotanshinone but not tanshinone IIA inhibits angiogenesis in vitro

Jong Moon Hur, Joong Sup Shim, Hye Jin Jung, Ho Jeong Kwon

Research output: Contribution to journalArticle

66 Citations (Scopus)

Abstract

In the course of screening of angiogenesis inhibitor from natural products, cryptotanshinone from Salvia miltiorrhiza was isolated as a potent small molecule inhibitor of angiogenesis. Cryptotanshinone inhibits bFGF-induced angiogenesis of BAECs at ten micromolar ranges in vitro without cytotoxicity. Tanshinone IIA, another tanshinone isolated from S. miltiorrhiza, which is structurally very similar to cryptotanshinone except C-15 position of dihydrofuran ring does not inhibit angiogenesis induced by bFGF. These results demonstrate that cryptotanshinone is a new anti-angiogenic agent and double bond at C-15 position of the dihydrofuran ring plays a crucial role in the activity.

Original languageEnglish
Pages (from-to)133-137
Number of pages5
JournalExperimental and Molecular Medicine
Volume37
Issue number2
DOIs
Publication statusPublished - 2005 Apr 30

Fingerprint

Salvia miltiorrhiza
Angiogenesis Inhibitors
Cytotoxicity
Biological Products
Screening
Molecules
cryptotanshinone
tanshinone
In Vitro Techniques
C 15

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Clinical Biochemistry

Cite this

Hur, Jong Moon ; Shim, Joong Sup ; Jung, Hye Jin ; Kwon, Ho Jeong. / Cryptotanshinone but not tanshinone IIA inhibits angiogenesis in vitro. In: Experimental and Molecular Medicine. 2005 ; Vol. 37, No. 2. pp. 133-137.
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Cryptotanshinone but not tanshinone IIA inhibits angiogenesis in vitro. / Hur, Jong Moon; Shim, Joong Sup; Jung, Hye Jin; Kwon, Ho Jeong.

In: Experimental and Molecular Medicine, Vol. 37, No. 2, 30.04.2005, p. 133-137.

Research output: Contribution to journalArticle

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