Cryptotanshinone but not tanshinone IIA inhibits angiogenesis in vitro

Jong Moon Hur, Joong Sup Shim, Hye Jin Jung, Ho Jeong Kwon

Research output: Contribution to journalArticle

68 Citations (Scopus)

Abstract

In the course of screening of angiogenesis inhibitor from natural products, cryptotanshinone from Salvia miltiorrhiza was isolated as a potent small molecule inhibitor of angiogenesis. Cryptotanshinone inhibits bFGF-induced angiogenesis of BAECs at ten micromolar ranges in vitro without cytotoxicity. Tanshinone IIA, another tanshinone isolated from S. miltiorrhiza, which is structurally very similar to cryptotanshinone except C-15 position of dihydrofuran ring does not inhibit angiogenesis induced by bFGF. These results demonstrate that cryptotanshinone is a new anti-angiogenic agent and double bond at C-15 position of the dihydrofuran ring plays a crucial role in the activity.

Original languageEnglish
Pages (from-to)133-137
Number of pages5
JournalExperimental and Molecular Medicine
Volume37
Issue number2
DOIs
Publication statusPublished - 2005 Apr 30

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Clinical Biochemistry

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