Crystal structure of GSK3β in complex with the flavonoid, morin

Kuglae Kim, Jeong Seok Cha, Jin Sik Kim, Jinsook Ahn, Nam Chul Ha, Hyun Soo Cho

Research output: Contribution to journalArticle

Abstract

GSK3β is a key kinase that plays a role in cellular signaling pathways. In Alzheimer's disease (AD), GSK3β has been implicated in hyperphosphorylation of tau proteins in the neuron, which is a hallmark of AD. Morin, a flavonoid that is abundant in nature, was found as an inhibitor of GSK3β that can reduce tau pathology in vivo and in vitro. In this study, we determined the crystal structure of GSK3β in complex with morin. The structure revealed that morin inhibits GSK3β by binding to the ATP binding pocket. Our findings augment the potential of morin as a functional food to help prevent AD, as well as to provide structural information to develop new therapeutics based on the morin skeleton.

Original languageEnglish
Pages (from-to)519-524
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume504
Issue number2
DOIs
Publication statusPublished - 2018 Oct 2

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Flavonoids
Crystal structure
Alzheimer Disease
Cell signaling
tau Proteins
Functional Food
Pathology
Skeleton
Neurons
Phosphotransferases
Adenosine Triphosphate
morin
Therapeutics

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this

Kim, Kuglae ; Cha, Jeong Seok ; Kim, Jin Sik ; Ahn, Jinsook ; Ha, Nam Chul ; Cho, Hyun Soo. / Crystal structure of GSK3β in complex with the flavonoid, morin. In: Biochemical and Biophysical Research Communications. 2018 ; Vol. 504, No. 2. pp. 519-524.
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Crystal structure of GSK3β in complex with the flavonoid, morin. / Kim, Kuglae; Cha, Jeong Seok; Kim, Jin Sik; Ahn, Jinsook; Ha, Nam Chul; Cho, Hyun Soo.

In: Biochemical and Biophysical Research Communications, Vol. 504, No. 2, 02.10.2018, p. 519-524.

Research output: Contribution to journalArticle

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