Curative resection of single primary hepatic malignancy: Liver imaging reporting and data system category lr-m portends a worse prognosis

Chansik An, Sumi Park, Yong Eun Chung, Do Young Kim, Seung Seob Kim, Myeong Jin Kim, Jin Young Choi

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

OBJECTIVE. The purpose of this study was to examine the associations between preoperative Liver Imaging Reporting and Data System (LI-RADS) categories and prognosis after curative resection of single hepatic malignancies in patients with chronic liver disease. MATERIALS AND METHODS. Between January 2008 and December 2010, 225 patients with chronic liver disease underwent resection of single hepatic malignant tumors (218 hepatocellular carcinomas, three cholangiocarcinomas, four biphenotypic carcinomas) after undergoing gadoxetic acid-enhanced MRI. Two radiologists retrospectively categorized the tumors into LI-RADS categories. Differences in disease-free survival duration between categories were analyzed by the Kaplan-Meier method with the log-rank test. RESULTS. Reviewer 1 categorized two (0.9%) patients as having LR-3, 53 (23.6%) LR-4, 159 (70.7%) LR-5, and 11 (4.9%) LR-M lesions. The corresponding numbers for reviewer 2 were six (2.7%) LR-3, 30 (13.3%) LR-4, 178 (79.1%) LR-5, and 11 (4.9%) LR-M. The 2-year cumulative recurrence or death rates were 15.1% for lesions categorized LR-3 or LR-4 by reviewer 1, 31.7% for LR-5, and 60% for LR-M. For lesions categorized by reviewer 2 the corresponding rates were 20.6% for LR-3 or LR-4, 29% for LR-5, and 54.5% for LR-M. Diseasefree survival was significantly worse among patients with lesions categorized as LR-M than for lesions categorized as LR-3 or LR-4 or as LR-5 (p < 0.01 for both reviewers). Disease-free survival did not significantly differ between patients with LR-3 or LR-4 and those with LR-5 lesions (reviewer 1, p = 0.301; reviewer 2, p = 0.291). CONCLUSION. Patients with tumors preoperatively categorized as LR-M may have a worse prognosis than those with tumors categorized LR-3, LR-4, or LR-5 after curative resection of single hepatic malignancy.

Original languageEnglish
Pages (from-to)576-583
Number of pages8
JournalAmerican Journal of Roentgenology
Volume209
Issue number3
DOIs
Publication statusPublished - 2017 Sep

Fingerprint

Information Systems
Liver
Neoplasms
Disease-Free Survival
Liver Diseases
Chronic Disease
Cholangiocarcinoma
Hepatocellular Carcinoma
Carcinoma
Recurrence
Survival
Mortality

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

Cite this

An, Chansik ; Park, Sumi ; Chung, Yong Eun ; Kim, Do Young ; Kim, Seung Seob ; Kim, Myeong Jin ; Choi, Jin Young. / Curative resection of single primary hepatic malignancy : Liver imaging reporting and data system category lr-m portends a worse prognosis. In: American Journal of Roentgenology. 2017 ; Vol. 209, No. 3. pp. 576-583.
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title = "Curative resection of single primary hepatic malignancy: Liver imaging reporting and data system category lr-m portends a worse prognosis",
abstract = "OBJECTIVE. The purpose of this study was to examine the associations between preoperative Liver Imaging Reporting and Data System (LI-RADS) categories and prognosis after curative resection of single hepatic malignancies in patients with chronic liver disease. MATERIALS AND METHODS. Between January 2008 and December 2010, 225 patients with chronic liver disease underwent resection of single hepatic malignant tumors (218 hepatocellular carcinomas, three cholangiocarcinomas, four biphenotypic carcinomas) after undergoing gadoxetic acid-enhanced MRI. Two radiologists retrospectively categorized the tumors into LI-RADS categories. Differences in disease-free survival duration between categories were analyzed by the Kaplan-Meier method with the log-rank test. RESULTS. Reviewer 1 categorized two (0.9{\%}) patients as having LR-3, 53 (23.6{\%}) LR-4, 159 (70.7{\%}) LR-5, and 11 (4.9{\%}) LR-M lesions. The corresponding numbers for reviewer 2 were six (2.7{\%}) LR-3, 30 (13.3{\%}) LR-4, 178 (79.1{\%}) LR-5, and 11 (4.9{\%}) LR-M. The 2-year cumulative recurrence or death rates were 15.1{\%} for lesions categorized LR-3 or LR-4 by reviewer 1, 31.7{\%} for LR-5, and 60{\%} for LR-M. For lesions categorized by reviewer 2 the corresponding rates were 20.6{\%} for LR-3 or LR-4, 29{\%} for LR-5, and 54.5{\%} for LR-M. Diseasefree survival was significantly worse among patients with lesions categorized as LR-M than for lesions categorized as LR-3 or LR-4 or as LR-5 (p < 0.01 for both reviewers). Disease-free survival did not significantly differ between patients with LR-3 or LR-4 and those with LR-5 lesions (reviewer 1, p = 0.301; reviewer 2, p = 0.291). CONCLUSION. Patients with tumors preoperatively categorized as LR-M may have a worse prognosis than those with tumors categorized LR-3, LR-4, or LR-5 after curative resection of single hepatic malignancy.",
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Curative resection of single primary hepatic malignancy : Liver imaging reporting and data system category lr-m portends a worse prognosis. / An, Chansik; Park, Sumi; Chung, Yong Eun; Kim, Do Young; Kim, Seung Seob; Kim, Myeong Jin; Choi, Jin Young.

In: American Journal of Roentgenology, Vol. 209, No. 3, 09.2017, p. 576-583.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Curative resection of single primary hepatic malignancy

T2 - Liver imaging reporting and data system category lr-m portends a worse prognosis

AU - An, Chansik

AU - Park, Sumi

AU - Chung, Yong Eun

AU - Kim, Do Young

AU - Kim, Seung Seob

AU - Kim, Myeong Jin

AU - Choi, Jin Young

PY - 2017/9

Y1 - 2017/9

N2 - OBJECTIVE. The purpose of this study was to examine the associations between preoperative Liver Imaging Reporting and Data System (LI-RADS) categories and prognosis after curative resection of single hepatic malignancies in patients with chronic liver disease. MATERIALS AND METHODS. Between January 2008 and December 2010, 225 patients with chronic liver disease underwent resection of single hepatic malignant tumors (218 hepatocellular carcinomas, three cholangiocarcinomas, four biphenotypic carcinomas) after undergoing gadoxetic acid-enhanced MRI. Two radiologists retrospectively categorized the tumors into LI-RADS categories. Differences in disease-free survival duration between categories were analyzed by the Kaplan-Meier method with the log-rank test. RESULTS. Reviewer 1 categorized two (0.9%) patients as having LR-3, 53 (23.6%) LR-4, 159 (70.7%) LR-5, and 11 (4.9%) LR-M lesions. The corresponding numbers for reviewer 2 were six (2.7%) LR-3, 30 (13.3%) LR-4, 178 (79.1%) LR-5, and 11 (4.9%) LR-M. The 2-year cumulative recurrence or death rates were 15.1% for lesions categorized LR-3 or LR-4 by reviewer 1, 31.7% for LR-5, and 60% for LR-M. For lesions categorized by reviewer 2 the corresponding rates were 20.6% for LR-3 or LR-4, 29% for LR-5, and 54.5% for LR-M. Diseasefree survival was significantly worse among patients with lesions categorized as LR-M than for lesions categorized as LR-3 or LR-4 or as LR-5 (p < 0.01 for both reviewers). Disease-free survival did not significantly differ between patients with LR-3 or LR-4 and those with LR-5 lesions (reviewer 1, p = 0.301; reviewer 2, p = 0.291). CONCLUSION. Patients with tumors preoperatively categorized as LR-M may have a worse prognosis than those with tumors categorized LR-3, LR-4, or LR-5 after curative resection of single hepatic malignancy.

AB - OBJECTIVE. The purpose of this study was to examine the associations between preoperative Liver Imaging Reporting and Data System (LI-RADS) categories and prognosis after curative resection of single hepatic malignancies in patients with chronic liver disease. MATERIALS AND METHODS. Between January 2008 and December 2010, 225 patients with chronic liver disease underwent resection of single hepatic malignant tumors (218 hepatocellular carcinomas, three cholangiocarcinomas, four biphenotypic carcinomas) after undergoing gadoxetic acid-enhanced MRI. Two radiologists retrospectively categorized the tumors into LI-RADS categories. Differences in disease-free survival duration between categories were analyzed by the Kaplan-Meier method with the log-rank test. RESULTS. Reviewer 1 categorized two (0.9%) patients as having LR-3, 53 (23.6%) LR-4, 159 (70.7%) LR-5, and 11 (4.9%) LR-M lesions. The corresponding numbers for reviewer 2 were six (2.7%) LR-3, 30 (13.3%) LR-4, 178 (79.1%) LR-5, and 11 (4.9%) LR-M. The 2-year cumulative recurrence or death rates were 15.1% for lesions categorized LR-3 or LR-4 by reviewer 1, 31.7% for LR-5, and 60% for LR-M. For lesions categorized by reviewer 2 the corresponding rates were 20.6% for LR-3 or LR-4, 29% for LR-5, and 54.5% for LR-M. Diseasefree survival was significantly worse among patients with lesions categorized as LR-M than for lesions categorized as LR-3 or LR-4 or as LR-5 (p < 0.01 for both reviewers). Disease-free survival did not significantly differ between patients with LR-3 or LR-4 and those with LR-5 lesions (reviewer 1, p = 0.301; reviewer 2, p = 0.291). CONCLUSION. Patients with tumors preoperatively categorized as LR-M may have a worse prognosis than those with tumors categorized LR-3, LR-4, or LR-5 after curative resection of single hepatic malignancy.

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