Curcuminoids from Curcuma longa and their inhibitory activities on influenza A neuraminidases

Trong Tuan Dao, Phi Hung Nguyen, Ho Keun Won, Eun Hee Kim, Junsoo Park, Boo Yeon Won, Won Keun Oh

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

The emergence of drug-resistant influenza viruses and the threat of pandemics highlight the need for new and effective antiviral agents. In this study, we describe the isolation of 3 new (1-3) and 10 known (4-13) curcuminoids from a methanol extract of Curcuma longa L. All compounds had strong inhibitory effects on the neuraminidases from two influenza viral strains, H1N1 and H9N2, as noncompetitive inhibitors with IC 50 values ranging from 6.18 ± 0.64 to 40.17 ± 0.79 μg/ml and 3.77 ± 0.75 to 31.82 ± 1.33 μg/ml, respectively. Compounds 4, 5, and 13 also exhibited significant inhibitory activity against the neuraminidases from novel influenza H1N1 (WT) and oseltamivir-resistant novel H1N1 (H274Y mutant) expressed in 293T cells. Our results suggest that the curcuminoids from C. longa may be potential supplemental molecules in the prevention and treatment of disease by influenza viruses.

Original languageEnglish
Pages (from-to)21-28
Number of pages8
JournalFood Chemistry
Volume134
Issue number1
DOIs
Publication statusPublished - 2012 Sep 1

Fingerprint

Curcuma
Curcuma longa
sialidase
Neuraminidase
Orthomyxoviridae
Viruses
influenza
Human Influenza
antiviral agents
Oseltamivir
HEK293 Cells
Pandemics
pandemic
Antiviral Agents
Methanol
inhibitory concentration 50
methanol
drugs
mutants
Molecules

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Food Science

Cite this

Dao, Trong Tuan ; Nguyen, Phi Hung ; Won, Ho Keun ; Kim, Eun Hee ; Park, Junsoo ; Won, Boo Yeon ; Oh, Won Keun. / Curcuminoids from Curcuma longa and their inhibitory activities on influenza A neuraminidases. In: Food Chemistry. 2012 ; Vol. 134, No. 1. pp. 21-28.
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Curcuminoids from Curcuma longa and their inhibitory activities on influenza A neuraminidases. / Dao, Trong Tuan; Nguyen, Phi Hung; Won, Ho Keun; Kim, Eun Hee; Park, Junsoo; Won, Boo Yeon; Oh, Won Keun.

In: Food Chemistry, Vol. 134, No. 1, 01.09.2012, p. 21-28.

Research output: Contribution to journalArticle

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