Current Knowledge on the Function of α-Methyl Acyl-CoA Racemase in Human Diseases

Gyeyeong Kong; Hyunji Lee; Quangdon Tran; Chaeyeong Kim; Nayoung Gong; Jisoo Park; So Hee Kwon; Seon Hwan Kim; Jongsun Park

doi:10.3389/fmolb.2020.00153

Current Knowledge on the Function of α-Methyl Acyl-CoA Racemase in Human Diseases

Gyeyeong Kong, Hyunji Lee, Quangdon Tran, Chaeyeong Kim, Nayoung Gong, Jisoo Park, So Hee Kwon, Seon Hwan Kim, Jongsun Park

Department of Pharmacy

Research output: Contribution to journal › Review article › peer-review

5 Citations (Scopus)

Abstract

Branched chain fatty acids perform very important functions in human diet and drug metabolism. they cannot be metabolized in mitochondria and are instead processed and degraded in peroxisomes due to the presence of methyl groups on the carbon chains. Oxidative degradation pathways for lipids include α- and β-oxidation and several pathways. In all metabolic pathways, α-methyl acyl-CoA racemase (AMACR) plays an essential role by regulating the metabolism of lipids and drugs. AMACR regulates β-oxidation of branched chain lipids in peroxisomes and mitochondria and promotes chiral reversal of 2-methyl acids. AMACR defects cause sensory-motor neuronal and liver abnormalities in humans. These phenotypes are inherited and are caused by mutations in AMACR. In addition, AMACR has been found to be overexpressed in prostate cancer. In addition, the protein levels of AMACR have increased significantly in many types of cancer. Therefore, AMACR may be an important marker in tumors. In this review, a comprehensive overview of AMACR studies in human disease will be described.

Original language	English
Article number	153
Journal	Frontiers in Molecular Biosciences
Volume	7
DOIs	https://doi.org/10.3389/fmolb.2020.00153
Publication status	Published - 2020 Jul 14

Bibliographical note

Funding Information:
Funding. This work was financially supported by a research fund from the Chungnam National University (grant to S-HK) and by the National Research Foundation of Korea (NRF) grant funded by the Korea Government (MEST) (NRF-2020R1F1A1 049801).

Publisher Copyright:
© Copyright © 2020 Kong, Lee, Tran, Kim, Gong, Park, Kwon, Kim and Park.

All Science Journal Classification (ASJC) codes

Biochemistry
Molecular Biology
Biochemistry, Genetics and Molecular Biology (miscellaneous)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3389/fmolb.2020.00153

Cite this

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title = "Current Knowledge on the Function of α-Methyl Acyl-CoA Racemase in Human Diseases",

abstract = "Branched chain fatty acids perform very important functions in human diet and drug metabolism. they cannot be metabolized in mitochondria and are instead processed and degraded in peroxisomes due to the presence of methyl groups on the carbon chains. Oxidative degradation pathways for lipids include α- and β-oxidation and several pathways. In all metabolic pathways, α-methyl acyl-CoA racemase (AMACR) plays an essential role by regulating the metabolism of lipids and drugs. AMACR regulates β-oxidation of branched chain lipids in peroxisomes and mitochondria and promotes chiral reversal of 2-methyl acids. AMACR defects cause sensory-motor neuronal and liver abnormalities in humans. These phenotypes are inherited and are caused by mutations in AMACR. In addition, AMACR has been found to be overexpressed in prostate cancer. In addition, the protein levels of AMACR have increased significantly in many types of cancer. Therefore, AMACR may be an important marker in tumors. In this review, a comprehensive overview of AMACR studies in human disease will be described.",

author = "Gyeyeong Kong and Hyunji Lee and Quangdon Tran and Chaeyeong Kim and Nayoung Gong and Jisoo Park and Kwon, {So Hee} and Kim, {Seon Hwan} and Jongsun Park",

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AU - Park, Jisoo

AU - Kwon, So Hee

AU - Kim, Seon Hwan

AU - Park, Jongsun

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PY - 2020/7/14

Y1 - 2020/7/14

N2 - Branched chain fatty acids perform very important functions in human diet and drug metabolism. they cannot be metabolized in mitochondria and are instead processed and degraded in peroxisomes due to the presence of methyl groups on the carbon chains. Oxidative degradation pathways for lipids include α- and β-oxidation and several pathways. In all metabolic pathways, α-methyl acyl-CoA racemase (AMACR) plays an essential role by regulating the metabolism of lipids and drugs. AMACR regulates β-oxidation of branched chain lipids in peroxisomes and mitochondria and promotes chiral reversal of 2-methyl acids. AMACR defects cause sensory-motor neuronal and liver abnormalities in humans. These phenotypes are inherited and are caused by mutations in AMACR. In addition, AMACR has been found to be overexpressed in prostate cancer. In addition, the protein levels of AMACR have increased significantly in many types of cancer. Therefore, AMACR may be an important marker in tumors. In this review, a comprehensive overview of AMACR studies in human disease will be described.

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Current Knowledge on the Function of α-Methyl Acyl-CoA Racemase in Human Diseases

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

UN SDGs

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