Current laboratory tests for diagnosis of hepatitis B virus infection

Jong Han Lee, Hyon Suk Kim

Research output: Contribution to journalReview articlepeer-review

2 Citations (Scopus)


Background: Hepatitis B virus (HBV) has a long history in human infectious diseases. HBV infection can progress chronically, leading to cancer. After introduction of a vaccine, the overall incidence rate of HBV infection has decreased, although it remains a health problem in many countries. Purpose: The aim of this review was to summarise current diagnostic efforts for HBV infection and future HBV diagnosis perspectives. Methods: We reviewed and summarised current laboratory diagnosis related with HBV infection in clinical practice. Results: There have been various serologic- and molecular-based methods to diagnose acute or chronic HBV infection. Since intrahepatic covalently closed circular DNAs (cccDNAs) function as robust HBV replication templates, cure of chronic HBV infection is limited. Recently, new biomarkers such as hepatitis B virus core-related antigen (HBcrAg) and HBV RNA have emerged that appear to reflect intrahepatic cccDNA status. These new biomarkers should be validated before clinical usage. Conclusion: An effective diagnostic approach and current updated knowledge of treatment response monitoring are important for HBV infection management. Brand new ultrasensitive and accurate immunologic methods may pave the way to manage HBV infection in parallel with immunotherapy era.

Original languageEnglish
Article numbere14812
JournalInternational Journal of Clinical Practice
Issue number12
Publication statusPublished - 2021 Dec

Bibliographical note

Publisher Copyright:
© 2021 John Wiley & Sons Ltd.

All Science Journal Classification (ASJC) codes

  • Medicine(all)


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