Current trends in patients with chronic total occlusions undergoing coronary CT angiography

Maksymilian P. Opolski, Bríain O. Hartaigh, Daniel S. Berman, Matthew J. Budoff, Stephan Achenbach, Mouaz Al-Mallah, Daniele Andreini, Filippo Cademartiri, Hyuk Jae Chang, Kavitha Chinnaiyan, Benjamin J.W. Chow, Martin Hadamitzky, Joerg Hausleiter, Gudrun Feuchtner, Yong Jin Kim, Philipp A. Kaufmann, Jonathon Leipsic, Erica Maffei, Gianluca Pontone, Gilbert RaffLeslee J. Shaw, Todd C. Villines, James K. Min

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Abstract

Objective: Data describing the prevalence, characteristics and management of coronary chronic total occlusions (CTOs) in patients undergoing coronary CT angiography (CCTA) have not been reported. The purpose of this study was to determine the prevalence, characteristics and treatment strategies of CTO identified by CCTA. Methods: We identified 23 745 patients who underwent CCTA for suspected coronary artery disease (CAD) from the prospective international CCTA registry. Baseline clinical data were collected, and allocation to early coronary revascularisation performed within 90 days of CCTA was determined. Multivariable hierarchical mixed-effects logistic regression reporting OR with 95% CI was performed. Results: The prevalence of CTO was 1.4% (342/23 745) in all patients and 6.2% in patients with obstructive CAD (≥50% stenosis). The presence of CTO was independently associated with male sex (OR 3.12, 95% CI 2.39 to 4.08, p<0.001), smoking (OR 2.02, 95% CI 1.55 to 2.64, p<0.001), diabetes (OR 1.60, 95% CI 1.22 to 2.11, p=0.001), typical angina (OR 1.51, 95% CI 1.12 to 2.06, p=0.008), hypertension (OR 1.47, 95% CI 1.14 to 1.88, p=0.003), family history of CAD (OR 1.30, 95% CI 1.01 to 1.67, p=0.04) and age (OR 1.06, 95% CI 1.05 to 1.07, p<0.001). Most patients with CTO (61%) were treated medically, while 39% underwent coronary revascularisation. In patients with severe CAD (.70% stenosis), CTO independently predicted revascularisation by coronary artery bypass grafting (OR 3.41, 95% CI 2.06 to 5.66, p<0.001), but not by percutaneous coronary intervention (p=0.83). Conclusions: CTOs are not uncommon in a contemporary CCTA population, and are associated with age, gender, angina status and CAD risk factors. Most individuals with CTO undergoing CCTA are managed medically with higher rates of surgical revascularisation in patients with versus without CTO. Trial registration number: ClinicalTrials.gov identifier NCT01443637.

Original languageEnglish
Pages (from-to)1212-1218
Number of pages7
JournalHeart
Volume101
Issue number15
DOIs
Publication statusPublished - 2015 Aug 1

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Coronary Angiography
Coronary Artery Disease
Pathologic Constriction
Percutaneous Coronary Intervention
Computed Tomography Angiography
Coronary Artery Bypass
Registries
Logistic Models
Smoking
Hypertension
Population

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Opolski, M. P., Hartaigh, B. O., Berman, D. S., Budoff, M. J., Achenbach, S., Al-Mallah, M., ... Min, J. K. (2015). Current trends in patients with chronic total occlusions undergoing coronary CT angiography. Heart, 101(15), 1212-1218. https://doi.org/10.1136/heartjnl-2014-306616
Opolski, Maksymilian P. ; Hartaigh, Bríain O. ; Berman, Daniel S. ; Budoff, Matthew J. ; Achenbach, Stephan ; Al-Mallah, Mouaz ; Andreini, Daniele ; Cademartiri, Filippo ; Chang, Hyuk Jae ; Chinnaiyan, Kavitha ; Chow, Benjamin J.W. ; Hadamitzky, Martin ; Hausleiter, Joerg ; Feuchtner, Gudrun ; Kim, Yong Jin ; Kaufmann, Philipp A. ; Leipsic, Jonathon ; Maffei, Erica ; Pontone, Gianluca ; Raff, Gilbert ; Shaw, Leslee J. ; Villines, Todd C. ; Min, James K. / Current trends in patients with chronic total occlusions undergoing coronary CT angiography. In: Heart. 2015 ; Vol. 101, No. 15. pp. 1212-1218.
@article{3b361fc3d50b45e0b920ab8243b2e30c,
title = "Current trends in patients with chronic total occlusions undergoing coronary CT angiography",
abstract = "Objective: Data describing the prevalence, characteristics and management of coronary chronic total occlusions (CTOs) in patients undergoing coronary CT angiography (CCTA) have not been reported. The purpose of this study was to determine the prevalence, characteristics and treatment strategies of CTO identified by CCTA. Methods: We identified 23 745 patients who underwent CCTA for suspected coronary artery disease (CAD) from the prospective international CCTA registry. Baseline clinical data were collected, and allocation to early coronary revascularisation performed within 90 days of CCTA was determined. Multivariable hierarchical mixed-effects logistic regression reporting OR with 95{\%} CI was performed. Results: The prevalence of CTO was 1.4{\%} (342/23 745) in all patients and 6.2{\%} in patients with obstructive CAD (≥50{\%} stenosis). The presence of CTO was independently associated with male sex (OR 3.12, 95{\%} CI 2.39 to 4.08, p<0.001), smoking (OR 2.02, 95{\%} CI 1.55 to 2.64, p<0.001), diabetes (OR 1.60, 95{\%} CI 1.22 to 2.11, p=0.001), typical angina (OR 1.51, 95{\%} CI 1.12 to 2.06, p=0.008), hypertension (OR 1.47, 95{\%} CI 1.14 to 1.88, p=0.003), family history of CAD (OR 1.30, 95{\%} CI 1.01 to 1.67, p=0.04) and age (OR 1.06, 95{\%} CI 1.05 to 1.07, p<0.001). Most patients with CTO (61{\%}) were treated medically, while 39{\%} underwent coronary revascularisation. In patients with severe CAD (.70{\%} stenosis), CTO independently predicted revascularisation by coronary artery bypass grafting (OR 3.41, 95{\%} CI 2.06 to 5.66, p<0.001), but not by percutaneous coronary intervention (p=0.83). Conclusions: CTOs are not uncommon in a contemporary CCTA population, and are associated with age, gender, angina status and CAD risk factors. Most individuals with CTO undergoing CCTA are managed medically with higher rates of surgical revascularisation in patients with versus without CTO. Trial registration number: ClinicalTrials.gov identifier NCT01443637.",
author = "Opolski, {Maksymilian P.} and Hartaigh, {Br{\'i}ain O.} and Berman, {Daniel S.} and Budoff, {Matthew J.} and Stephan Achenbach and Mouaz Al-Mallah and Daniele Andreini and Filippo Cademartiri and Chang, {Hyuk Jae} and Kavitha Chinnaiyan and Chow, {Benjamin J.W.} and Martin Hadamitzky and Joerg Hausleiter and Gudrun Feuchtner and Kim, {Yong Jin} and Kaufmann, {Philipp A.} and Jonathon Leipsic and Erica Maffei and Gianluca Pontone and Gilbert Raff and Shaw, {Leslee J.} and Villines, {Todd C.} and Min, {James K.}",
year = "2015",
month = "8",
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doi = "10.1136/heartjnl-2014-306616",
language = "English",
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pages = "1212--1218",
journal = "Heart",
issn = "1355-6037",
publisher = "BMJ Publishing Group",
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Opolski, MP, Hartaigh, BO, Berman, DS, Budoff, MJ, Achenbach, S, Al-Mallah, M, Andreini, D, Cademartiri, F, Chang, HJ, Chinnaiyan, K, Chow, BJW, Hadamitzky, M, Hausleiter, J, Feuchtner, G, Kim, YJ, Kaufmann, PA, Leipsic, J, Maffei, E, Pontone, G, Raff, G, Shaw, LJ, Villines, TC & Min, JK 2015, 'Current trends in patients with chronic total occlusions undergoing coronary CT angiography', Heart, vol. 101, no. 15, pp. 1212-1218. https://doi.org/10.1136/heartjnl-2014-306616

Current trends in patients with chronic total occlusions undergoing coronary CT angiography. / Opolski, Maksymilian P.; Hartaigh, Bríain O.; Berman, Daniel S.; Budoff, Matthew J.; Achenbach, Stephan; Al-Mallah, Mouaz; Andreini, Daniele; Cademartiri, Filippo; Chang, Hyuk Jae; Chinnaiyan, Kavitha; Chow, Benjamin J.W.; Hadamitzky, Martin; Hausleiter, Joerg; Feuchtner, Gudrun; Kim, Yong Jin; Kaufmann, Philipp A.; Leipsic, Jonathon; Maffei, Erica; Pontone, Gianluca; Raff, Gilbert; Shaw, Leslee J.; Villines, Todd C.; Min, James K.

In: Heart, Vol. 101, No. 15, 01.08.2015, p. 1212-1218.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Current trends in patients with chronic total occlusions undergoing coronary CT angiography

AU - Opolski, Maksymilian P.

AU - Hartaigh, Bríain O.

AU - Berman, Daniel S.

AU - Budoff, Matthew J.

AU - Achenbach, Stephan

AU - Al-Mallah, Mouaz

AU - Andreini, Daniele

AU - Cademartiri, Filippo

AU - Chang, Hyuk Jae

AU - Chinnaiyan, Kavitha

AU - Chow, Benjamin J.W.

AU - Hadamitzky, Martin

AU - Hausleiter, Joerg

AU - Feuchtner, Gudrun

AU - Kim, Yong Jin

AU - Kaufmann, Philipp A.

AU - Leipsic, Jonathon

AU - Maffei, Erica

AU - Pontone, Gianluca

AU - Raff, Gilbert

AU - Shaw, Leslee J.

AU - Villines, Todd C.

AU - Min, James K.

PY - 2015/8/1

Y1 - 2015/8/1

N2 - Objective: Data describing the prevalence, characteristics and management of coronary chronic total occlusions (CTOs) in patients undergoing coronary CT angiography (CCTA) have not been reported. The purpose of this study was to determine the prevalence, characteristics and treatment strategies of CTO identified by CCTA. Methods: We identified 23 745 patients who underwent CCTA for suspected coronary artery disease (CAD) from the prospective international CCTA registry. Baseline clinical data were collected, and allocation to early coronary revascularisation performed within 90 days of CCTA was determined. Multivariable hierarchical mixed-effects logistic regression reporting OR with 95% CI was performed. Results: The prevalence of CTO was 1.4% (342/23 745) in all patients and 6.2% in patients with obstructive CAD (≥50% stenosis). The presence of CTO was independently associated with male sex (OR 3.12, 95% CI 2.39 to 4.08, p<0.001), smoking (OR 2.02, 95% CI 1.55 to 2.64, p<0.001), diabetes (OR 1.60, 95% CI 1.22 to 2.11, p=0.001), typical angina (OR 1.51, 95% CI 1.12 to 2.06, p=0.008), hypertension (OR 1.47, 95% CI 1.14 to 1.88, p=0.003), family history of CAD (OR 1.30, 95% CI 1.01 to 1.67, p=0.04) and age (OR 1.06, 95% CI 1.05 to 1.07, p<0.001). Most patients with CTO (61%) were treated medically, while 39% underwent coronary revascularisation. In patients with severe CAD (.70% stenosis), CTO independently predicted revascularisation by coronary artery bypass grafting (OR 3.41, 95% CI 2.06 to 5.66, p<0.001), but not by percutaneous coronary intervention (p=0.83). Conclusions: CTOs are not uncommon in a contemporary CCTA population, and are associated with age, gender, angina status and CAD risk factors. Most individuals with CTO undergoing CCTA are managed medically with higher rates of surgical revascularisation in patients with versus without CTO. Trial registration number: ClinicalTrials.gov identifier NCT01443637.

AB - Objective: Data describing the prevalence, characteristics and management of coronary chronic total occlusions (CTOs) in patients undergoing coronary CT angiography (CCTA) have not been reported. The purpose of this study was to determine the prevalence, characteristics and treatment strategies of CTO identified by CCTA. Methods: We identified 23 745 patients who underwent CCTA for suspected coronary artery disease (CAD) from the prospective international CCTA registry. Baseline clinical data were collected, and allocation to early coronary revascularisation performed within 90 days of CCTA was determined. Multivariable hierarchical mixed-effects logistic regression reporting OR with 95% CI was performed. Results: The prevalence of CTO was 1.4% (342/23 745) in all patients and 6.2% in patients with obstructive CAD (≥50% stenosis). The presence of CTO was independently associated with male sex (OR 3.12, 95% CI 2.39 to 4.08, p<0.001), smoking (OR 2.02, 95% CI 1.55 to 2.64, p<0.001), diabetes (OR 1.60, 95% CI 1.22 to 2.11, p=0.001), typical angina (OR 1.51, 95% CI 1.12 to 2.06, p=0.008), hypertension (OR 1.47, 95% CI 1.14 to 1.88, p=0.003), family history of CAD (OR 1.30, 95% CI 1.01 to 1.67, p=0.04) and age (OR 1.06, 95% CI 1.05 to 1.07, p<0.001). Most patients with CTO (61%) were treated medically, while 39% underwent coronary revascularisation. In patients with severe CAD (.70% stenosis), CTO independently predicted revascularisation by coronary artery bypass grafting (OR 3.41, 95% CI 2.06 to 5.66, p<0.001), but not by percutaneous coronary intervention (p=0.83). Conclusions: CTOs are not uncommon in a contemporary CCTA population, and are associated with age, gender, angina status and CAD risk factors. Most individuals with CTO undergoing CCTA are managed medically with higher rates of surgical revascularisation in patients with versus without CTO. Trial registration number: ClinicalTrials.gov identifier NCT01443637.

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DO - 10.1136/heartjnl-2014-306616

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Opolski MP, Hartaigh BO, Berman DS, Budoff MJ, Achenbach S, Al-Mallah M et al. Current trends in patients with chronic total occlusions undergoing coronary CT angiography. Heart. 2015 Aug 1;101(15):1212-1218. https://doi.org/10.1136/heartjnl-2014-306616