Current trends of the incidence and pathological diagnosis of gastroenteropancreatic neuroendocrine tumors (GEP-NETs) in Korea 2000-2009: Multicenter study

Mee Yon Cho, Joon Mee Kim, Jin Hee Sohn, Mi Jung Kim, Kyoung Mee Kim, Woo Ho Kim, Hyunki Kim, Myeong Cherl Kook, Do Youn Park, Jae Hyuk Lee, Hee Kyung Chang, Eun Sun Jung, Hee Kyung Kim, So Young Jin, Joon Hyuk Choi, Mi Jin Gu, Sujin Kim, Mi Seon Kang, Chang Ho Cho, Moon Il ParkYun Kyung Kang, Youn Wha Kim, Sun Och Yoon, Han Ik Bae, Mee Joo, Woo Sung Moon, Dae Young Kang, Sei Jin Chang

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Abstract

Purpose: As a result of various independently proposed nomenclatures and classifications, there is confusion in the diagnosis and prediction of biological behavior of gastroenteropancreatic neuroendocrine tumors (GEP-NETs). A comprehensive nationwide study is needed in order to understand the biological characteristics of GEP-NETs in Korea. Materials and Methods: We collected 4,951 pathology reports from 29 hospitals in Korea between 2000 and 2009. Kaplan-Meier survival analysis was used to determine the prognostic significance of clinicopathological parameters. Results: Although the GEP-NET is a relatively rare tumor in Korea, its incidence has increased during the last decade, with the most significant increase found in the rectum. The 10-year survival rate for well-differentiated endocrine tumor was 92.89%, in contrast to 85.74% in well differentiated neuroendocrine carcinoma and 34.59% in poorly differentiated neuroendocrine carcinoma. Disease related death was most common in the biliary tract (62.2%) and very rare in the rectum (5.2%). In Kaplan-Meier survival analysis, tumor location, histological classification, extent, size, mitosis, Ki-67 labeling index, synaptophysin expression, lymphovascular invasion, perineural invasion, and lymph node metastasis showed prognostic significance (p<0.05), however, chromogranin expression did not (p=0.148). The 2000 and 2010 World Health Organization (WHO) classification proposals were useful for prediction of the prognosis of GEP-NET. Conclusion: The incidence of GEP-NET in Korea has shown a remarkable increase during the last decade, however, the distribution of tumors in the digestive system differs from that of western reports. Assessment of pathological parameters, including immunostaining, is crucial in understanding biological behavior of the tumor as well as predicting prognosis of patients with GEP-NET.

Original languageEnglish
Pages (from-to)157-165
Number of pages9
JournalCancer Research and Treatment
Volume44
Issue number3
DOIs
Publication statusPublished - 2012

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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    Cho, M. Y., Kim, J. M., Sohn, J. H., Kim, M. J., Kim, K. M., Kim, W. H., Kim, H., Kook, M. C., Park, D. Y., Lee, J. H., Chang, H. K., Jung, E. S., Kim, H. K., Jin, S. Y., Choi, J. H., Gu, M. J., Kim, S., Kang, M. S., Cho, C. H., ... Chang, S. J. (2012). Current trends of the incidence and pathological diagnosis of gastroenteropancreatic neuroendocrine tumors (GEP-NETs) in Korea 2000-2009: Multicenter study. Cancer Research and Treatment, 44(3), 157-165. https://doi.org/10.4143/crt.2012.44.3.157